Impact of vaccination uptake on hospitalizations due to rotavirus acute gastroenteritis in 2 different socioeconomic areas of Spain

Sánchez, F. Giménez; Nogueira, Esperanza Jiménez; Forte, Miguel; Alcalde, Mercedes Ibáñez; Cobo, Elvira; Angulo, Raquel Ferrer; Fernández, Pablo Garrido

doi:10.1080/21645515.2015.1118592

Cited by 6 publications

(8 citation statements)

References 26 publications

(25 reference statements)

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“…19,20 Thus post-vaccination, the mortality rates due to RVGE substantially declined primarily in high-income settings and the hospitalization rates were positively impacted (50-80%). 21,22 As of 2018, RV vaccine has been introduced in the NIP of 97 countries ( Figure 1) (with 90 countries having introduced a universal mass vaccination program [UMV]), 23,24 meaning that less than one-third of the world's birth cohort has access to RV vaccines. 25,26 Although deaths due to RVGE have declined, there remains a significant direct and indirect disease burden due to the large numbers of RVGE cases, hospitalizations and associated complications.…”

Section: Introductionmentioning

confidence: 99%

“…13,28 Despite the availability of safe and efficacious vaccines, RV vaccination remains underutilized in infants, which is in contrast with observed vaccination coverage rates with most primary childhood vaccines which have remained stable and high. 22,25,29 The reasons for underutilization are similar in both high-and low-income settings (Text box 1) 30,31 A common misconception among parents is that improved hygiene and cleanliness would prevent cases of RVGE. However, the fact that pre-vaccine RVGE rates are universally similar indicates that hygiene practices are not sufficient to reduce transmission of RV.…”

Section: Introductionmentioning

confidence: 99%

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Role of healthcare practitioners in rotavirus disease awareness and vaccination – insights from a survey among caregivers

Benninghoff

Pereira

Vetter

2019

Human Vaccines & Immunotherapeutics

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An online survey was designed to assess awareness and understanding of Rotavirus (RV) gastroenteritis (RVGE), and knowledge and attitudes towards RV vaccination in Germany, Poland, Turkey, Indonesia, the Philippines and Thailand. Survey participants (n = 1500) comprised parents, expectant parents and guardians of children ≤5 years of age who have sole or joint responsibility for health and well-being decisions relating to their child, who were recruited from an online panel and provided their consent for study participation. Participants from most countries had a high level of awareness of RV infections (mean: 82%) and of those aware of RV, a mean of 61% participants were aware that RV was the most common cause of GE, however the majority (mean: 59%) were unaware that nearly every child would be infected with RVGE by the age of 5 years. Healthcare professional (HCP) recommendation was identified as the key driver for participants seeking vaccination (48%-75% of participants stated this reason, with results differing by country) followed by availability of RV vaccine in the national immunization program. Despite a high level of awareness of RVGE among participants, fostering knowledge regarding the difficulty of RVGE prevention, the risk of RV contraction and the associated serious consequences like dehydration is imperative to improve RV vaccination uptake. HCPs, being the primary influence on participants' decision on vaccination, are best suited to bridge existing knowledge gaps and recommend parents to vaccinate their children against RVGE.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Role of healthcare practitioners in rotavirus disease awareness and vaccination – insights from a survey among caregivers

Benninghoff

Pereira

Vetter

2019

Human Vaccines & Immunotherapeutics

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“…Impact of RV vaccines in hospitalizations has already been described in different countries [ 4 , 9 – 11 ]. However, 9 years after the introduction of rotavirus vaccines in Spain, the proportion of the RVAGE-hospitalization rate reduction directly attributable to vaccination remains unclear due to the large variation in the rate reductions found between studies, ranging from 14 to 44.5% and 10 to 57% in children <5 and <1 years of age, respectively, even with similar vaccination coverage [ 4 – 6 , 12 ]. Along the same lines, wide differences in the annual incidence of RVAGE and all-cause AGE-hospitalizations were also found [ 4 – 6 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, 9 years after the introduction of rotavirus vaccines in Spain, the proportion of the RVAGE-hospitalization rate reduction directly attributable to vaccination remains unclear due to the large variation in the rate reductions found between studies, ranging from 14 to 44.5% and 10 to 57% in children <5 and <1 years of age, respectively, even with similar vaccination coverage [ 4 – 6 , 12 ]. Along the same lines, wide differences in the annual incidence of RVAGE and all-cause AGE-hospitalizations were also found [ 4 – 6 , 12 ]. This variability supposes a limitation to make comparisons and creates uncertainty when making decisions about the potential inclusion of the vaccine in the official immunization schedule.…”

Section: Introductionmentioning

confidence: 99%

Long-term impact of self-financed rotavirus vaccines on rotavirus-associated hospitalizations and costs in the Valencia Region, Spain

et al. 2017

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BackgroundRotavirus vaccines are available in Spain from 2007. They are recommended by the Spanish Pediatric Association, but not funded by the National Health System (NHS) and its coverage rate reached 40-50%. The hospitalization rate reduction of rotavirus caused gastroenteritis (RVAGE) directly attributable to vaccination remains unclear due to the large differences described in published studies, ranging from 14 to 44.5% in children <5 years of age, even with similar vaccination coverage. These results could be partly explained by variability in hospitalization policies, different study designs and the timeframe of observation. In addition, the direct economic impact of the reduction of hospitalizations has never been estimated. Therefore, there is a need to analyze the long-term impact of rotavirus vaccines on RVAGE and all cause gastroenteritis (AGE) hospitalizations and the national health system associated costs, minimizing potential confounders or biases.MethodsA population-based, ecological study using the hospital discharge registry’s Minimum Basic Data Set (MBDS) and the vaccine register (SIV) was performed, among Valencia Region’s children <5 years old, during 2002 - 2015. RVAGE and AGE hospitalization risk was analyzed by vaccine coverage and adjusted by the total hospitalization rate for all causes to avoid external biases. The impact of AGE-associated health care utilization in prevaccine (2003–2006) versus postvaccine (2008–2014) years was also assessed.ResultsAfter vaccines licensure, the incidence of RVAGE-associated hospitalizations decreased markedly. A general vaccine coverage-related reduction in RVAGE or AGE-hospitalizations risk was observed in all age groups. Compared with unvaccinated children, RVAGE hospitalization risk decreased by 67% (95% CI: 55-67), 71% (95% CI: 58-81) and 68% (95% CI: 18-92) in children 0, 1 and 4 years of age, respectively, with a vaccination coverage between 40 and 42%. Overall, the hospital related costs were reduced around EUR 6 Mill per 105 children in 7 years.ConclusionsDespite the low-medium vaccine coverage, the introduction of rotavirus vaccines had a specific coverage-related response impact in the hospitalizations for RVAGE and AGE in children <5 years and their use substantially reduced hospital related costs. The model used reassures that the estimated impact is due to the vaccination and not to other external factors.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-017-2380-2) contains supplementary material, which is available to authorized users.

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“…In terms of the influence of socioeconomic factors on rotavirus vaccination, ecological studies suggest that the most deprived areas have the lowest coverage and higher rates of hospitalization for acute gastroenteritis caused by rotavirus [ 24 , 34 , 35 ]. However, ecological studies were not able to evaluate socioeconomic factors and vaccine uptake with consideration of the influence of parental perceptions, recommendations received, and other individual-level determinants.…”

Section: Discussionmentioning

confidence: 99%

Determinants of self-paid rotavirus vaccination status in Kanazawa, Japan, including socioeconomic factors, parents’ perception, and children’s characteristics

Hara

Koshida²,

Araki

et al. 2020

BMC Infect Dis

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Background Japan’s National Immunization Program does not cover rotavirus vaccine and no government subsidies are available. This study aimed to measure the uptake of and determinants that influenced self-paid rotavirus vaccination, including socioeconomic status and relative poverty. Methods We conducted a cross-sectional study at health check-ups for all children aged 18 months in Kanazawa, Japan, between December 2017 and July 2018. Community nurses collected information on self-paid vaccination history, parents’ perceptions of and recommendations for rotavirus vaccine, and socioeconomic status in interviews using a unified questionnaire. We used multivariable logistic regression to assess vaccine uptake and possible determinants. Results In total, 1282 participants were enrolled. The estimated rotavirus vaccine coverage was 72.9%. Perceptions that rotavirus gastroenteritis was serious and that the rotavirus vaccine was effective, pediatricians’ recommendations, information from the city office, magazine and Internet articles, and higher parental education level were associated with higher rotavirus vaccine uptake. Lower household income was associated with decreased rotavirus vaccine uptake. Vaccine expense, fear of adverse reactions to the vaccine, number of household members and siblings, and children’s characteristics were not correlated with rotavirus vaccination. Poverty was associated with decreased rotavirus vaccine uptake, even after adjustment for other determinants (adjusted odds ratio 0.49, 95% confidence interval: 0.26–0.90). Conclusion Parents’ perceptions, socioeconomic status, relative poverty, and pediatricians’ recommendations are determinants of vaccination. This study suggests that appropriate information about rotavirus vaccine, subsidies for those of lower socioeconomic status, and national recommendations are necessary to achieve higher coverage.

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Impact of vaccination uptake on hospitalizations due to rotavirus acute gastroenteritis in 2 different socioeconomic areas of Spain

Cited by 6 publications

References 26 publications

Role of healthcare practitioners in rotavirus disease awareness and vaccination – insights from a survey among caregivers

Role of healthcare practitioners in rotavirus disease awareness and vaccination – insights from a survey among caregivers

Long-term impact of self-financed rotavirus vaccines on rotavirus-associated hospitalizations and costs in the Valencia Region, Spain

Determinants of self-paid rotavirus vaccination status in Kanazawa, Japan, including socioeconomic factors, parents’ perception, and children’s characteristics

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