New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis

Yuan, Ting; Yang, Ting; Chen, Huan; Fu, Danli; Hu, Yangyang; Wang, Jing; Yuan, Qing; Yu, Hong; Xu, Wangyang; Xie, Xiang

doi:10.1016/j.redox.2018.09.025

Cited by 439 publications

(369 citation statements)

References 215 publications

(251 reference statements)

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“…This further upregulates the ROS production, leading to diabetes induced atherosclerosis. 28,29 Therefore, when serum glucose is controlled, even in the context of obesity, there could be a downplay of stress which in turn decreases the previously mentioned heightened release of cytokines and chemokines. A few studies investigated the relation between obesity and inflammation among patients with diabetes according to their glycemic control.…”

Section: Discussionmentioning

confidence: 99%

<p>Abdominal Fat Is Directly Associated With Inflammation In Persons With Type-2 Diabetes Regardless Of Glycemic Control – A Jordanian Study</p>

Bawadi¹,

Katkhouda²,

Tayyem³

et al. 2019

DMSO

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Background and aim: Systemic inflammation is related to the progression of complications associated with diabetes. This study aimed to investigate the association between general and abdominal obesity and inflammation in patients with type-2 diabetes with or without glycemic control. Methods: A total of 198 men (n=73) and women (n=125) diagnosed with type 2 diabetes participated in this study. General obesity markers, body mass index (BMI), and abdominal fat were assessed. Circulating concentrations of glycated hemoglobin (HbA1C), C-reactive protein (CRP), and serum interleukin-6 (IL-6) were determined. Poor glycemic control and good glycemic control were defined as having fasting HbA1C concentrations ≥7% and <7%, respectively. Multivariate adjusted analysis of covariance was used to determine the relation between BMI and abdominal fat and markers of inflammation in patients with good and poor glycemic control. Results: Patients in <7% HbA1C category, those with high abdominal fat had ≈262% higher CRP and ≈30.6% higher IL-6 compared to those with low abdominal fat (p˂0.05). Patients in ≥7% HbA1C category, those with high abdominal fat had ≈41.4% higher CRP and ≈33.9%higher IL-6 compared to those with low abdominal fat (p˂0.05). Abdominal fat was directly related to CRP (p˂0.023) and IL-6 (p˂0.002) concentrations in both groups of type-2 diabetic patients with <7% and ≥7% HbA1C. In patients with ≥7% HbA1C, BMI was directly related to CRP (p˂0.02) and IL-6 (p˂0.047). Whereas in patients with <7% HbA1C, BMI was not associated with CRP or IL-6 concentrations. Conclusion: High level of abdominal fat is associated with systemic inflammation in type-2 diabetes regardless of glycemic control. Abdominal fat is a better predictor (determinant) of inflammation than BMI in patients with type-2 diabetes with or without glycemic control.

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Section: Discussionmentioning

confidence: 99%

<p>Abdominal Fat Is Directly Associated With Inflammation In Persons With Type-2 Diabetes Regardless Of Glycemic Control – A Jordanian Study</p>

Bawadi¹,

Katkhouda²,

Tayyem³

et al. 2019

DMSO

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“…Considering the relevance of proinflammatory and prooxidant pathways in the pathogenesis of age-related diseases, AGEs are involved in relevant illnesses such as diabetes [59][60][61], insulin resistance, cardiovascular diseases [62,63], chronic renal failure [64], and neurological disorders [65,66].…”

Section: Reactive Oxygen Species/reactive Nitrogen Species Are Intermmentioning

confidence: 99%

Redox Signaling and Advanced Glycation Endproducts (AGEs) in Diet-Related Diseases

et al. 2020

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Diets are currently characterized by elevated sugar intake, mainly due to the increased consumption of processed sweetened foods and drinks during the last 40 years. Diet is the main source of advanced glycation endproducts (AGEs). These are toxic compounds formed during the Maillard reaction, which takes place both in vivo, in tissues and fluids under physiological conditions, favored by sugar intake, and ex vivo during food preparation such as baking, cooking, frying or storage. Protein glycation occurs slowly and continuously through life, driving AGE accumulation in tissues during aging. For this reason, AGEs have been proposed as a risk factor in the pathogenesis of diet-related diseases such as diabetes, insulin resistance, cardiovascular diseases, kidney injury, and age-related and neurodegenerative diseases. AGEs are associated with an increase in oxidative stress since they mediate the production of reactive oxygen species (ROS), increasing the intracellular levels of hydrogen peroxide (H2O2), superoxide (O2−), and nitric oxide (NO). The interaction of AGEs with the receptor for AGEs (RAGE) enhances oxidative stress through ROS production by NADPH oxidases inside the mitochondria. This affects mitochondrial function and ultimately influences cell metabolism under various pathological conditions. This short review will summarize all evidence that relates AGEs and ROS production, their relationship with diet-related diseases, as well as the latest research about the use of natural compounds with antioxidant properties to prevent the harmful effects of AGEs on health.

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“…Most ROS that are generated as by-products during mitochondrial electron transport and reactive nitrogen species (RNS) are peroxynitrites and nitric oxide, contributing to the role in the development of cardiovascular disease [71]. The specific markers of ROS are altered to inflammation that enhanced the risk of atherosclerosis by diabetes [72]. The vasodilator activity of NO may be unique among therapeutic options for management of hypertension, renal disease, and left ventricular hypertrophy [73].…”

Section: Cardiovascular Diseases 41 Free Radical Cause Nitric Oxidementioning

confidence: 99%

Diseases Related to Types of Free Radicals

Maddu¹

2019

Antioxidants

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The free radicals are reactive molecules with electron-rich groups produced during metabolic reactions occurring in the cells. These free radicals are collectively known as reactive oxygen species (ROS) and reactive nitrogen species (RNS). Lipid peroxidation products and protein carbonyls species are under the group of ROS, and nitric oxide and peroxynitrites are under the group of RNS. The malondialdehyde that reacts with LDL-C indirectly induced the risk of atherosclerosis. The protein carbonyls acts as marker of protein oxidation and exerts damage to proteins. The nitric oxide plays an important role in DNA damage, inflammation, proliferation of cancer cells, and dysfunction of apoptosis. The peroxynitrites could induce the process of lipid peroxidation, DNA damage, and may exert chronic damage to all biomolecules. The aim of the present study is that the free radicals may react with biomolecules of the cells and play an important role in the development of chronic disease conditions in the humans.

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New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis

Cited by 439 publications

References 215 publications

<p>Abdominal Fat Is Directly Associated With Inflammation In Persons With Type-2 Diabetes Regardless Of Glycemic Control – A Jordanian Study</p>

<p>Abdominal Fat Is Directly Associated With Inflammation In Persons With Type-2 Diabetes Regardless Of Glycemic Control – A Jordanian Study</p>

Redox Signaling and Advanced Glycation Endproducts (AGEs) in Diet-Related Diseases

Diseases Related to Types of Free Radicals

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