New Insights into Alterations in PL Proteins Affecting Their Binding to DNA after Exposure of Mytilus galloprovincialis to Mercury—A Possible Risk to Sperm Chromatin Structure?

Lettieri, Gennaro; Notariale, Rosaria; Carusone, Nadia; Giarra, Antonella; Trifuoggi, Marco; Manna, Caterina; Piscopo, Marina

doi:10.3390/ijms22115893

Cited by 19 publications

(24 citation statements)

References 63 publications

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“…In this study, we did not find any difference in the expression of seven candidate miRNAs between the drug-treated group and drug-naïve group, minimizing the contamination of miRNA expression by drug treatment in the following studies. Sex-based differences of miRNAs have been reported in human brains as well as in peripheral blood component from literatures, including miR-320 and miR-221 20 , 21 . In this study, we compared seven candidate miRNAs expression between male and female in both duplication set and validation set, and failed to find stable sex-based difference.…”

Section: Discussionmentioning

confidence: 99%

Elevated plasma miR-133b and miR-221-3p as biomarkers for early Parkinson’s disease

Chen

Deng

Lü

et al. 2021

Sci Rep

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Blood circulating microRNAs (miRNAs) are proposed to be promising biomarkers for many neurodegenerative disorders, including Parkinson’s disease (PD). However, there is a lack of identified differentially expressed miRNAs in PD from different studies. The aim of this study was to evaluate miRNAs expression in PD. We measured plasma circulating miRNA expression in three independent sets with a total of 151 PD patients, 21 multiple system atrophy (MSA) patients and 138 healthy controls using high-throughput RT-PCR. We identified that elevated miR-133b and miR-221-3p discriminated early-stage PD from controls with 94.4% sensitivity and 91.1% specificity. Elevated miR-133b and miR-221-3p distinguished PD from controls with 84.8% sensitivity and 88.9% specificity. In addition, miR-4454 distinguished PD from MSA with 57.1% sensitivity and 82.6% specificity. Hence, elevated miR-133b and miR-221-3p potentially represent good biomarkers for early PD, and a combination of miR-133b, miR-221-3p and miR-4454 has the potential to serve as a non-invasive biomarker for PD diagnosis.

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Section: Discussionmentioning

confidence: 99%

Elevated plasma miR-133b and miR-221-3p as biomarkers for early Parkinson’s disease

Chen

Deng

Lü

et al. 2021

Sci Rep

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“…It is well known that environmental pollution has negative consequences on the health of various organisms including humans, and also on their reproduction [28][29][30][31][32][33][34][35][36][37]. Very few studies have been conducted on the impact of pollution on the female reproductive system versus the male one.…”

Section: Discussionmentioning

confidence: 99%

Could Kallikrein-Related Serine Peptidase 3 Be an Early Biomarker of Environmental Exposure in Young Women?

Raimondo¹,

Gentile²,

Esposito³

et al. 2021

IJERPH

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Bisphenols and phthalates affect androgen receptor-mediated signaling that directly regulates Kallikrein-Related serine Peptidase 3 (KLK3) secretion, indicating that environmental factors may play a role in KLK3 secretion. With the aim of obtaining preliminary data on whether KLK3 could serve as an early marker of environmental pollution effects, in 61 and 58 healthy women living in a high environmental impact (HEI) and low environmental impact (LEI) area, respectively, serum KLK3 levels at different phases of menstrual cycle were measured. KLK3 values resulted in always being higher in the HEI group with respect to the LEI group. These differences were particularly relevant in the ovulatory phase (cycle day 12°–13°) of the menstrual cycle. The differences in KLK3 values during the three phases of the menstrual cycle were significant in the LEI group differently from the HEI group. In addition, higher progesterone levels were observed in the LEI group with respect to the HEI group in the luteal phase, indicating an opposite trend of KLK3 and progesterone in this phase of the menstrual cycle. Although changes in KLK3 could also depend on other factors, these preliminary data could be an early indication of an expanding study of the role of biomarkers in assessing early environmental effects for female reproductive health.

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“…The limit of detection (LOD) was calculated by the method of blank variability for each investigated metal, and they were included in the range of 0.01-0.2 µg/g in the final sample. The accuracy was evaluated using Certificated Reference Material (CRM) of a fish-based sample from an interlaboratory comparison (QMAS, MT-281 Sample 742, LGC Standards Srl, Milano, Italy), obtaining a recovery in the range of 85-115% [46].…”

Section: Metals Quantificationmentioning

confidence: 99%

Comparative Fatty Acid Profiling of Edible Fishes in Kuala Terengganu, Malaysia

Tramice

Trifuoggi

Ahmad

et al. 2021

Foods

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The aim of this study was to compare the relative nutritional benefit of edible Malaysian fishes from the coast of Terengganu in Malaysia, as well as to perform a taxonomical characterization and metal assessment. Discrimination between species was carried out by a morphological and molecular approach by evaluating the total concentrations of metals by ICP-MS analyses and the fatty acids (FA) composition using the GC–MS approach on the fish fillet tissues. The taxonomical studies detected fishes of 11 families and 13 species. The heavy metal assessment showed that all detected elements did not exceed the regulatory limit stated by Malaysian Food Regulations. The proportion of saturated fatty acids (SFA) ranged from 33 to 58.34%, followed by the polyunsaturated fatty acids (PUFA) values from 24 to 51.8%, and the lowest proportion was of monounsaturated fatty acids (MUFA), ranging from 12.7 to 35.9%. The ω-3/ω-6 PUFA and PUFA/SFA ratios were determined in the range 1.1 to 7.4 and 0.35 to 1.6, respectively. The C20:5 ω-3 and C22:6 ω-3 acids were detected at levels comparable to those found in the corresponding species from similar tropical marine ecosystems. The high FA values can be useful biochemical tools for comparing the relative nutritional benefits of these biodiverse and non-toxic edible Malaysian fishes.

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New Insights into Alterations in PL Proteins Affecting Their Binding to DNA after Exposure of Mytilus galloprovincialis to Mercury—A Possible Risk to Sperm Chromatin Structure?

Cited by 19 publications

References 63 publications

Elevated plasma miR-133b and miR-221-3p as biomarkers for early Parkinson’s disease

Elevated plasma miR-133b and miR-221-3p as biomarkers for early Parkinson’s disease

Could Kallikrein-Related Serine Peptidase 3 Be an Early Biomarker of Environmental Exposure in Young Women?

Comparative Fatty Acid Profiling of Edible Fishes in Kuala Terengganu, Malaysia

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