New indium-111 labeled biotin derivatives for improved immunotargeting

Virzi, F.; Fritz, B. A.; Rusckowski, Mary; Gionet, M.; Misra, Hemant; Hnatowich, Donald J.

doi:10.1016/0883-2897(91)90010-i

Cited by 12 publications

(15 citation statements)

References 11 publications

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“…Avidin may be a less immunogenic substitute for streptavidin (65) possibly only because its glycosylation encourages rapid accumulation into the liver (66). While a simple two-step strategy was used initially to show proof-of-concept (67-70), most studies now include a clearing step prior to effector administration. Increasing the pretargeting interval, i.e.…”

Section: Pretargeting Systemsmentioning

confidence: 99%

A Semiempirical Model of Tumor Pretargeting

Liu

Hnatowich

2008

Bioconjugate Chem.

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This article provides an overview of a semiempirical pretargeting model now under development. After a brief review of the pretargeting concept, the strategies available, and the complexities of optimizing the dosage and timing, a semiempirical model is described that is not only capable of optimizing dosage and timing but also capable of predicting the results of pretargeting as a function of most pretargeting variables. The model requires knowledge of the pharmacokinetics of both the pretargeting agent (usually an antibody) and the effector, the accessibility of the pretargeting antibody for the effector, and their quantitative relationships in vivo. Several misconceptions that often surround pretargeting are also clarified.

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Section: Pretargeting Systemsmentioning

confidence: 99%

A Semiempirical Model of Tumor Pretargeting

Liu

Hnatowich

2008

Bioconjugate Chem.

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“…The approach is based on the observation that infected, inflamed, necrotic, and malignant areas are able to nonspecifically accumulate large protein molecules, such as immunoglobulins or albumin (6,7) or even nanoparticulates (8) via the mechanism of impaired filtration. It was suggested to use (strept) avidin itself or (strept) avidin-antibody conjugate as a tumor-accumulating substance, and after its preliminary injection and accumulation, to target (i.e., to visualize) the tumor with a biotin-associated label (9)(10)(11). Different heavy metal ions serve usually as those labels, such as 111 In and 99m Tc (for γ-immunoscintigraphic visualization); Gd and Mn (for magnetic resonance imaging), or 186,188 Re and 90 Y (for tumor radiotherapy) (10).…”

mentioning

confidence: 99%

Biotin-Conjugated Polychelating Agent

Torchilin

1998

Bioconjugate Chem.

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A procedure is described for preparing a polychelating agent-biotin conjugate through the interaction of biotin-maleimide with poly-L-lysine modified with multiple residues of diethylenetriaminepentaacetic acid and containing amino-terminal pyridylthio-propionate group. The conjugate can be easily loaded with multiple metal atoms, such as 111In, and preserves its ability to specifically interact with avidin (as avidin-agarose). Polychelate-biotin conjugate may be used for signal amplification in visualization and analytical protocols involving the application of the avidin-biotin system.

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“…Biotin is an essential growth factor for some bacteria and is required for the metabolism of amino acids and fats. It is also involved in the production of fatty acids [189]. 111 Inlabeled biotin demonstrated avid uptake in cultures of S. aureus [190].…”

Section: Biotin (Vitamin H)mentioning

confidence: 99%

Synthetic approaches to radiochemical probes for imaging of bacterial infections

Dutta

Naicker

Ebenhan

et al. 2017

European Journal of Medicinal Chemistry

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This present review provides an account on the available synthetic strategies employed to radiolabel commercial and potential bacteria-selective probes for tomographic imaging. These molecular probes encompass leukocytes, antibodies, small molecules, peptides, antibiotics, macrolides, vitamins, oligomers and siderophores. Although this technique has shown to be a valuable tool for non-invasive infection imaging, more development is required to create easy-to-radiolabel kit solutions/procedures for the preparation of the probes.

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New indium-111 labeled biotin derivatives for improved immunotargeting

Cited by 12 publications

References 11 publications

A Semiempirical Model of Tumor Pretargeting

A Semiempirical Model of Tumor Pretargeting

Biotin-Conjugated Polychelating Agent

Synthetic approaches to radiochemical probes for imaging of bacterial infections

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