New indane and naphthalene derivatives from the rhizomes of Kniphofia reflexa Hutchinson ex Codd

Sema, Denis Kehdinga; Lannang, Alain Méli; Tatsimo, Simplice Joel N.; Rehman, Mujeeb Ur; Yousuf, Sammer; Zoufou, Denis; Iqbal, Urooj; Wansi, Jean Duplex; Sewald, Norbert; Choudhary, M. Iqbal

doi:10.1016/j.phytol.2018.05.025

Cited by 7 publications

(11 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, the acute toxicity as well as the in vivo antiplasmodial activities of the various extracts of K. folosia and its major constituents was evaluated against P. berghei in mice. Since members of the genus Kniphofia have been documented to produce anthraquinones and related phenols [ 46 , 47 ], the total extract was further fractionated into phenolic and nonphenolic fractions. Results of the current study demonstrated that the hydroalcoholic extract, the fractions as well as the isolated compounds significantly suppressed parasitaemia indicating that they possesses blood schizonticidal activity on early infection of mice with P. berghei .…”

Section: Resultsmentioning

confidence: 99%

In vivo anti-malarial activity of the hydroalcoholic extract of rhizomes of Kniphofia foliosa and its constituents

Alebachew

Bisrat

Tadesse

et al. 2021

Malar J

View full text Add to dashboard Cite

Background Kniphofia foliosa is a flamboyant robust perennial herb which has dense clumps and tick upright rhizomes with leaves at the base. In Ethiopia, it has several vernacular names including Abelbila, Ashenda, Amelmela, Yeznjero Ageda, Shemetmetie and Yezinjero Ageda. The plant is endemic to Ethiopian highlands, where its rhizomes are traditionally used for the treatment of malaria, abdominal cramps and wound healing. In the present study, the 80% methanol extract of K. foliosa rhizomes and its constituents are tested against Plasmodium berghei in mice. Methods Isolation was carried out using column and preparative thin layer chromatography (PTLC). The chemical structures of the compounds were elucidated by spectroscopic methods (ESI–MS, 1D and 2D-NMR). Peters’ 4-day suppressive test against P. berghei in mice was utilized for in vivo anti-malarial evaluation of the test substances. Results Two compounds, namely knipholone and dianellin were isolated from the 80% methanolic extract of K. foliosa rhizomes, and characterized. The hydroalcoholic extract (400 mg/kg) and knipholone (200 mg/kg) showed the highest activity with chemosuppression values of 61.52 and 60.16%, respectively. From the dose–response plot, the median effective (ED50) doses of knipholone and dianellin were determined to be 81.25 and 92.31 mg/kg, respectively. Molecular docking study revealed that knipholone had a strong binding affinity to Plasmodium falciparum l-lactate dehydrogenase (pfLDH) target. Conclusion Results of the current study support the traditional use of the plant for the treatment of malaria.

show abstract

Section: Resultsmentioning

confidence: 99%

In vivo anti-malarial activity of the hydroalcoholic extract of rhizomes of Kniphofia foliosa and its constituents

Alebachew

Bisrat

Tadesse

et al. 2021

Malar J

View full text Add to dashboard Cite

show abstract

“…The anti-inflammatory potential of the compound chrsophanol ( 5 ), which was obtained from the methanol crude extract fraction of Kniphofia reflexa rhizome, was also investigated (Sema et al. 2018 ).…”

Section: Review Methodologymentioning

confidence: 99%

“…It was found to be moderately cytotoxic with a CC 50 value of 11.24 μg/mL (Sema et al. 2018 ). The antimalarial and antiproliferative properties of chyslandicin ( 15 ), which was isolated from whole parts of an ethanolic crude extract of Kniphofia ensifolia , were investigated (Dai et al.…”

Section: Review Methodologymentioning

confidence: 99%

“…The compound, 10-(chrysophanol-7′-yl)-10-(ξ)-hydroxychrysophanol-9-anthrone ( 22 ) isolated from dichloromethane extract of Kniphofia foliosa roots was evaluated in vitro against the chloroquine-sensitive 3D7 strain of P. falciparum , and it significantly inhibited malaria parasite development with an ED 50 value of 0.26 μg/mL (Sema et al. 2018 ).…”

Section: Review Methodologymentioning

confidence: 99%

“…The compound ( 34 ) was extremely cytotoxic, with a CC 50 of 4.43 μg/mL (Sema et al. 2018 ). The antimalarial activity of a compound ( 36 ) isolated from 80% methanol rhizome extracts of Kniphofia foliosa was evaluated in mice against the chloroquine (CQ) sensitive ANKA strain of Plasmodium berghei .…”

Section: Review Methodologymentioning

confidence: 99%

See 2 more Smart Citations

A comprehensive review of the ethnomedicine, phytochemistry, pharmacological activities of the genus Kniphofia

Nigussie

Tegegn

Abeje

et al. 2022

Pharmaceutical Biology

View full text Add to dashboard Cite

Context Kniphofia (Asphodelaceae) is found mainly in South Africa and Tropical Africa. Malaria, hepatitis B, blood purifier, cancer, eczema, and female infertility have all been traditionally treated using this genus. Objective The current review provides a complete and up-to-date compilation of documented traditional medicinal uses, phytochemicals, and pharmacological activities of the genus. Method Relevant literature was collected by searching the major electronic scientific databases including PubMed, Science Direct, Web of Science, and Google Scholar using appropriate keywords ethnomedicinal studies, phytochemical investigations, and pharmacological activities of Kniphofia species. The search strategy included all articles with descriptors that were available until November 30, 2021. Only published works in English were used for this study. The data were collected using textual descriptions of the studies, tabulation, grouping, and figures. Result At present, more than 40 compounds have been isolated from different parts of Kniphofia species. The major compounds isolated from the Kniphofia species are monomeric anthraquinones and dimeric anthraquinones. Pharmacologically the extracts and isolated compounds showed antioxidant, antimalarial, antiproliferative, anti-HIV-1, anti-leukotriene, and cytotoxic activity. The genus afforded exemplary drug leads such as knipholone and knipholone anthrone with anti-HIV-1, antimalarial and cytotoxicity activity. Conclusions Kniphofia species have traditionally been used to treat a variety of diseases. Pharmacological actions of phytochemicals were shown to be promising. Despite this, considering the genus's inclusion on the red data list of South Africa, it deserves more attention. In order to find novel drug candidates, more studies on promising crude extracts and compounds are needed.

show abstract

Botanical description, ethnomedicinal uses, phytochemistry, and pharmacological activities of genus Kniphofia and Aloe: A review

Diriba

Deresa

2022

Arabian Journal of Chemistry

View full text Add to dashboard Cite

New indane and naphthalene derivatives from the rhizomes of Kniphofia reflexa Hutchinson ex Codd

Cited by 7 publications

References 19 publications

In vivo anti-malarial activity of the hydroalcoholic extract of rhizomes of Kniphofia foliosa and its constituents

In vivo anti-malarial activity of the hydroalcoholic extract of rhizomes of Kniphofia foliosa and its constituents

A comprehensive review of the ethnomedicine, phytochemistry, pharmacological activities of the genus Kniphofia

Botanical description, ethnomedicinal uses, phytochemistry, and pharmacological activities of genus Kniphofia and Aloe: A review

Contact Info

Product

Resources

About