Botanical description, ethnomedicinal uses, phytochemistry, and pharmacological activities of genus Kniphofia and Aloe: A review

Diriba, Tamiru Fayisa; Deresa, Ebisa Mirete

doi:10.1016/j.arabjc.2022.104111

Cited by 11 publications

(16 citation statements)

References 49 publications

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“…Aloe species have been used in ethnopharmacology, and studies on their phytochemical and pharmacological properties have produced several active ingredients. Herbalists have historically employed them to manage a variety of illnesses [ 7 ]. Aloe species are abundant natural sources of bioactive substances, with anthraquinones making up most of them [ 11 ].…”

Section: Bioactive Compounds/substances Present In Aloe Sec...mentioning

confidence: 99%

“…(Asphodelaceae) [ 6 ]. Its mucilaginous fluid is administered to wounds and cuts in rural areas of the continent to suppress infections and promote healing [ 7 ]. Aloe spp.…”

Section: Introductionmentioning

confidence: 99%

“…The Asphodelaceae family’s largest genus, Aloe , contains more than 400 species that range in size from small shrubs to large trees and are found throughout dry regions of Africa, India, and other regions [ 7 ]. The diversity of Aloe is greatest in South Africa.…”

Section: Introductionmentioning

confidence: 99%

“…On their leaves—especially the undersides—young plants frequently have dots. Up to 20 spreading branches, each with a cylinder raceme of pink-red flowers, can be seen on the tall (1 m) erect inflorescence [ 3 , 7 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Pharmacotherapeutic Potential of Aloe secundiflora against Colorectal Cancer Growth and Proliferation

Macharia,

Ngure,

Emődy

et al. 2023

Pharmaceutics

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Aloe species are widespread and diverse in African ecosystems, and this commonly correlates to their habitual use as reservoirs of herbal medicine. The side effects associated with chemotherapy and the development of antimicrobial resistance to empirically used antimicrobial drugs are substantial, paving the way for novel phytotherapeutic approaches. This comprehensive study aimed to evaluate and present Aloe secundiflora (A. secundiflora) as a compelling alternative with potential benefits in colorectal cancer (CRC) treatment. Important databases were systematically searched for relevant literature, and out of a large collection of 6421 titles and abstracts, only 68 full-text articles met the inclusion criteria. A. secundiflora possesses an abundant presence of bioactive phytoconstituents in the leaves and roots, including anthraquinones, naphthoquinones, phenols, alkaloids, saponins, tannins, and flavonoids, among others. These metabolites have proven diverse efficacy in inhibiting cancer growth. The presence of innumerable biomolecules in A. secundiflora signifies the beneficial effects of incorporating the plant as a potential anti-CRC agent. Nonetheless, we recommend further research to determine the optimal concentrations necessary to elicit beneficial effects in the management of CRC. Furthermore, they should be investigated as potential raw ingredients for making conventional medications.

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Section: Bioactive Compounds/substances Present In Aloe Sec...mentioning

confidence: 99%

“…(Asphodelaceae) [ 6 ]. Its mucilaginous fluid is administered to wounds and cuts in rural areas of the continent to suppress infections and promote healing [ 7 ]. Aloe spp.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pharmacotherapeutic Potential of Aloe secundiflora against Colorectal Cancer Growth and Proliferation

Macharia,

Ngure,

Emődy

et al. 2023

Pharmaceutics

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“…Herein, our project on K. schimperi was chosen based on the traditional medicinal application of the plant in the local community. So far, a number of compounds have been reported from the genus Kniphofia [ [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] ]. Yet, little is known about the phytochemical constituents of K. schimperi .…”

Section: Introductionmentioning

confidence: 99%

Chemical constituents of the roots of Kniphofia schimperi and evaluation of their antimicrobial activity

Deresa,

Abdissa,

Abdissa

2024

Heliyon

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Chemical Characterization, Evaluation of Acute Oral Toxicity, and Anti‐Diabetic Activity of Aloe sabaea Flowers Extract on Alloxan‐Induced Diabetic Rats

Raweh,

El‐Shaibany,

Al‐Mahbashi

et al. 2024

Chemistry & Biodiversity

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The study aimed to conduct chemical profiling, acute in‐vivo toxicity evaluation, and the potential anti‐diabetic effect of standardized Aloe sabaea flowers ethanolic extracts (ASFEE) on alloxan‐induced diabetic rats. The chemical composition was analyzed using GC–MS and TLC techniques. The oral acute toxicity study was performed according to the WHO 2000 and the OECD 420 guidelines. Furthermore, anti‐diabetic activity was investigated using two doses of ASFEE (0.2 and 0.5 g/kg/day BW, p.o.) compared with glibenclamide (5 mg/kg/day, p.o.). A molecular docking investigation of the identified components with the PTPN9 enzyme was performed to figure out the proposed anti‐diabetic mechanism. GC–MS analysis displayed the existence of 18 compounds; most of the compounds were fatty acids and their esters, and phytosterols. Total phenolic and flavonoid contents were 42.00±1.26 mg GAE/g DW and 22.21±1.55 mg QE/g DW, respectively. The results of the in‐vivo toxicity study revealed the absence of noticeable signs of toxicity or mortality at various doses establishing the safety of the tested extract. The estimated LD50 value was higher than 10 g/kg. Antidiabetic action exhibited a noticeable decline in fasting blood glucose (FBG) levels comparable to glibenclamide with no inducing intense hypoglycemia and considerable excess weight.

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Botanical description, ethnomedicinal uses, phytochemistry, and pharmacological activities of genus Kniphofia and Aloe: A review

Cited by 11 publications

References 49 publications

Pharmacotherapeutic Potential of Aloe secundiflora against Colorectal Cancer Growth and Proliferation

Pharmacotherapeutic Potential of Aloe secundiflora against Colorectal Cancer Growth and Proliferation

Chemical constituents of the roots of Kniphofia schimperi and evaluation of their antimicrobial activity

Chemical Characterization, Evaluation of Acute Oral Toxicity, and Anti‐Diabetic Activity of Aloe sabaea Flowers Extract on Alloxan‐Induced Diabetic Rats

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