New in vitro method for detecting asthma allergen

Changes of basophil reactivity to housedust extract and anti-lgE during immunotherapy was examined in thirteen patients with bronchial asthma sensitive to housedust. (i) A significant decrease in the morphological reactivity of basophils to housedust extract was observed 6 months after the beginning of immunotherapy with the antigen, and a significant decrease after 12 and 18 months' therapy, accompanied with the decrease of histamine release from the eells. The percent reactive basophils to the antigen decreased from 59-2±2-9% before the therapy to 40 0+1 8% after 18 months' immunotherapy. (ii) A decrease in the morphological reactivity of basophils to anti-lgE was also shown during immunotherapy. The basophil reactivity to anti-lgE decreased significantly at the late stage (18 months) of immunotherapy. (iii) A significant reduction of specific IgE antibody to housedust was observed 12 and 18 months after the beginning of immunotherapy. It was suggested from these results that immunotherapy causes some changes on the surface of basophils and decreased reactivity of the cells, and that a decrease of reactive basophils to anti-lgE in the process of immunotherapy might be due to a decrease in number of IgE receptors essentially or functionally.

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Decrease in reactivity of basophils by immunotherapy with housedust extract

Kimura

Tanizaki

Goda

et al. 1985

Clin Experimental Allergy

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Cellular Composition of Fluid in the Airways of Patients with House Dust Sensitive Asthma, Classified by Clinical Symptoms.

Tanizaki¹,

Kitani²,

Okazaki³

et al. 1992

Intern. Med.

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The cellular composition of bronchoalveolar lavage (BAL) fluid was observed in 28 patients with house dust mite-sensitive asthma. The proportion of neutrophils in the BAL fluid was significantly higher in the patients between the ages of 50 and 59 and those over 60 than in the patients younger than age 39. There was a significant difference in the number of neutrophiis in patients aged 30-39 years and in those over 40 at the onset of disease. The cellular composition varied among the three types of asthma; the mean percentage of cells in the BAL fluid was 1.1% neutrophils and 21.3% eosinophils in type la (simple bronchoconstriction), 9.1% neutrophils and 23.0% eosinophils in type Ib (bronchoconstriction + hypersecretion), and 34.4% neutro phils and 12.0% eosinophils in type II (bronchiolar obstruction). The results suggested that an increased frequency of both neutrophils and eosinophils correlates with the mechanism of hypersecretion, and that a marked increase in the proportion of neutrophils is involved in bronchiolar obstruction. (Internal Medicine 31: 333-338, 1992)

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The role of lymphocytes in bronchial asthma

Tamura

1985

Okayama I. Z.

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New in vitro method for detecting asthma allergen

Cited by 3 publications

References 11 publications

Decrease in reactivity of basophils by immunotherapy with housedust extract

Decrease in reactivity of basophils by immunotherapy with housedust extract

Cellular Composition of Fluid in the Airways of Patients with House Dust Sensitive Asthma, Classified by Clinical Symptoms.

The role of lymphocytes in bronchial asthma

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