Cellular Composition of Fluid in the Airways of Patients with House Dust Sensitive Asthma, Classified by Clinical Symptoms.

Tanizaki, Yoshiro; Kitani, Hikaru; Okazaki, Morihiro; Mifune, Takashi; Mitsunobu, Fumihiro; Ochi, Koji; Harada, Hideo

doi:10.2169/internalmedicine.31.333

Cited by 13 publications

(2 citation statements)

References 18 publications

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“…BAL was carried out according to a previously reported method [19,201 when the subjects were attack-free. Informed consent for this BAL procedure was obtained from all study subjects.…”

Section: Subjects and M Eth Odsmentioning

confidence: 99%

Changes in the Proportions of Bronchoalveolar Lymphocytes, Neutrophils and Basophilic Cells and the Release of Histamine and Leukotrienes from Bronchoalveolar Cells in Patients with Steroid-Dependent Intractable Asthma

Tanizaki¹,

Kitani²,

Okazaki³

et al. 1993

Int Arch Allergy Immunol

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The proportion of inflammatory cells in bronchoalveolar lavage (BAL) fluid and the release of chemical mediators from BAL and peripheral blood cells were examined in 40 patients with steroid-dependent intractable asthma (SDIA) to clarify the effects of a long-term glucocorticoid regimen on these cells. The proportion of BAL lymphocytes was significantly reduced (p < 0.01) and the proportion of BAL neutrophils was significantly increased (p < 0.01) in SDIA patients compared with non-SDIA patients. The proportion of basophilic cells (mast cells and basophils) in BAL fluid was significantly lower in SDIA patients compared to non-SDIA patients (p < 0.02). The values of six ventilatory parameters were significantly lower in SDIA patients with a high proportion of BAL neutrophils (more than 10%) compared with the values in non-SDIA patients. The release of histamine and leukotriene C₄ (LTC₄) from the BAL cells of patients with atopic asthma was significantly reduced in SDIA patients compared with non-SDIA patients (p < 0.05). These results show that the changes in the proportion of BAL cells are observed in patients with SDIA, and these changes are related to suppressed ventilatory function and a reduction in the release of histamine and LTC₄ from BAL cells.

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“…BAL was carried out according to a previously reported method [19,201 when the subjects were attack-free. Informed consent for this BAL procedure was obtained from all study subjects.…”

Section: Subjects and M Eth Odsmentioning

confidence: 99%

Changes in the Proportions of Bronchoalveolar Lymphocytes, Neutrophils and Basophilic Cells and the Release of Histamine and Leukotrienes from Bronchoalveolar Cells in Patients with Steroid-Dependent Intractable Asthma

Tanizaki¹,

Kitani²,

Okazaki³

et al. 1993

Int Arch Allergy Immunol

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“…Em pacientes asmáticos, a proporção aumentada de eosinófilos em relação aos neutrófilos no fluido bronco-alveoar está envolvida na obstrução brônquica característica da asma (Tanizaki et al, 1992 (Carvalho et al, 2004).…”

Section: Reações De Hipersensibilidade E Alérgenos Ambientaisunclassified

Caracterização quantitativa e funcional da transferência de anticorpos anti-Dermatophagoides pteronyssinus via placenta e colostro materno.

Macchiaverni¹

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Blomia tropicalis and Dermatophagoides pteronyssinus Mites Evoke Distinct Patterns of Airway Cellular Influx in Type I Hypersensitivity Murine Model

et al. 2004

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Murine models of hypersensitivity to allergens are useful tools for the evaluation of strategies to downmodulate IgE response. We sought to compare allergen inflammatory pulmonary response in previously sensitized mice orally administered with dust mites Blomia tropicalis (Bt) or Dermatophagoides pteronyssinus (Dp). Sensitized A/Sn mice fed with Bt or Dp showed a significant decrease in the IgE response compared to control-immunized mice. Bt-immunized mice demonstrated an accumulation of neutrophils in the bronchoalveolar lavage fluid, while Dp-immunized mice revealed an intense influx of eosinophils in the airway. Bt oral administration did not attenuate cell influx in the airway and Dp-fed mice showed a significant decrease of neutrophils and lymphocytes in the bronchoalveolar lavage fluid. These findings demonstrated that oral tolerance induction to Bt and Dp extract in sensitized mice decrease IgE response, but does not interfere in local inflammatory pulmonary response. The distinct profile of airway cellular infiltration between mites immunization suggest an interesting model to study allergic inflammation.

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Cellular Composition of Fluid in the Airways of Patients with House Dust Sensitive Asthma, Classified by Clinical Symptoms.

Cited by 13 publications

References 18 publications

Changes in the Proportions of Bronchoalveolar Lymphocytes, Neutrophils and Basophilic Cells and the Release of Histamine and Leukotrienes from Bronchoalveolar Cells in Patients with Steroid-Dependent Intractable Asthma

Changes in the Proportions of Bronchoalveolar Lymphocytes, Neutrophils and Basophilic Cells and the Release of Histamine and Leukotrienes from Bronchoalveolar Cells in Patients with Steroid-Dependent Intractable Asthma

Caracterização quantitativa e funcional da transferência de anticorpos anti-Dermatophagoides pteronyssinus via placenta e colostro materno.

Blomia tropicalis and Dermatophagoides pteronyssinus Mites Evoke Distinct Patterns of Airway Cellular Influx in Type I Hypersensitivity Murine Model

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