New immunology—immunology of pattern recognition receptors

Лебедев, К. А.; Ponyakina, I. D.

doi:10.1134/s1062359006050013

Cited by 11 publications

(19 citation statements)

References 45 publications

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“…Стало понятно, что неспецифическая резистентность в своей основе достаточно специфична и в зависимости от природы антигенного воздействия включает те или иные механизмы защиты. Рецепторным аппаратом этой системы оказались паттерн-распознающие рецепторы, действие которых заключается в распознавании «образа» того или иного антигена и соответственно мобилизации определенных рецепторных и регуляторных систем [1,2]. Это семейство представлено достаточно широко и, по последним данным, включает Толл-подобные рецепторы (ТЛР), Nod-подобные рецепторы и др.…”

Section: влияние имихимода на продукцию интерферона и развитиеunclassified

Influence of the Imiquimod on the Interferon Production and Treatment of the Experimental Herpes Simplex Virus Infection

Сергеевич¹,

Petlenko²

2017

Problems of Virology

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Background. Imiquimod is an imidazole derivative acting as an immunomodulator on the level of innate and adaptive immune system. Our objective was to evaluate the antiviral activity of generically reproduced imiquimod administered subcutaneously in mice and intravaginally in guinea pigs against herpes simplex virus (HSV), as well as to study the dynamics of serum interferon (IFN) synthesis under different dosing regimens. Results. When administered subcutaneously at doses of 0.5, 1.0 and 10 mg/kg imiquimod increased IFN production in mice in a dose-dependent manner with maximum serum IFN concentrations occurring 4 hours after dosing. Imiquimod protected mice from intraperitoneal HSV infection at doses of 3.2 and 32 LD50.The utmost protection (100% survival) was observed when imiquimod was administered at a dose of 100 mg/kg daily for 5 days before infection. Topical application of imiquimod 5% cream exhibited significantly more rapid and complete virus elimination in guinea pigs intravaginally infected with HSV type 2 compared to control group. Conclusion. Imiquimod produced as a generic possesses the same immunomodulatory and antiviral properties as the originally synthesized substance.

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Section: влияние имихимода на продукцию интерферона и развитиеunclassified

Influence of the Imiquimod on the Interferon Production and Treatment of the Experimental Herpes Simplex Virus Infection

Сергеевич¹,

Petlenko²

2017

Problems of Virology

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“…For each pair of dominant products, we use spherical coordinates that are centered at the midpoint between them. We use Gauss-Legendre quadrature for integrating along the radial coordinate and Lebedev quadrature [30] for integrating over solid angle…”

Section: The Exchange-correlation Kernelmentioning

confidence: 99%

A Parallel Iterative Method for Computing Molecular Absorption Spectra

Koval

Foêrster

Coulaud

2010

J. Chem. Theory Comput.

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We describe a fast parallel iterative method for computing molecular absorption spectra within TDDFT linear response and using the LCAO method. We use a local basis of "dominant products" to parametrize the space of orbital products that occur in the LCAO approach. In this basis, the dynamic polarizability is computed iteratively within an appropriate Krylov subspace. The iterative procedure uses a matrix-free GMRES method to determine the (interacting) density response. The resulting code is about 1 order of magnitude faster than our previous full-matrix method. This acceleration makes the speed of our TDDFT code comparable with codes based on Casida's equation. The implementation of our method uses hybrid MPI and OpenMP parallelization in which load balancing and memory access are optimized. To validate our approach and to establish benchmarks, we compute spectra of large molecules on various types of parallel machines. The methods developed here are fairly general, and we believe they will find useful applications in molecular physics/chemistry, even for problems that are beyond TDDFT, such as organic semiconductors, particularly in photovoltaics.

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“…In this section, we will explain (i) how to discretise the electronic spectral density on a frequency lattice and (ii) how to evaluate the spectral integral over the infinite frequency interval in eq. (19).…”

Section: Definition Of a Frequency Dependent Response Matrixmentioning

confidence: 99%

“…In spite of this, we used a simple numerical integration in spherical coordinates as an easy alternative to more elaborate integration techniques, with the center of spherical coordinates on the midpoint between the two centers, each associated with a dominant product. The integration over solid angle is done via Lebedev's method [19] and integration over the radial coordinates is done by the Gauss-Legendre method. By default, we use 86 grid points in Lebedev integration and 24 grid points in Gauss-Legendre integration.…”

Section: Computing the Kernels F H And F XC In A Basis Of Dominant Prmentioning

confidence: 99%

On the Kohn–Sham density response in a localized basis set

Foêrster

Koval

2009

The Journal of Chemical Physics

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We construct the Kohn-Sham density response function chi(0) in a previously described basis of the space of orbital products. The calculational complexity of our construction is O(N(2)N(omega)) for a molecule of N atoms and in a spectroscopic window of N(omega) frequency points. As a first application, we use chi(0) to calculate the molecular spectra from the Petersilka-Gossmann-Gross equation. With chi(0) as input, we obtain the correct spectra with an extra computational effort that grows also as O(N(2)N(omega)) and, therefore, less steeply in N than the O(N(3)) complexity of solving Casida's equations. Our construction should be useful for the study of excitons in molecular physics and in related areas where chi(0) is a crucial ingredient.

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New immunology—immunology of pattern recognition receptors

Cited by 11 publications

References 45 publications

Influence of the Imiquimod on the Interferon Production and Treatment of the Experimental Herpes Simplex Virus Infection

Influence of the Imiquimod on the Interferon Production and Treatment of the Experimental Herpes Simplex Virus Infection

A Parallel Iterative Method for Computing Molecular Absorption Spectra

On the Kohn–Sham density response in a localized basis set

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