New icetexane diterpenes with intestinal α-glucosidase inhibitory and free-radical scavenging activity isolated from Premna tomentosa roots

Terpene Compounds in Nature: A Review of Their Potential Antioxidant Activity

“…[34] marked DPPH antioxidant activity. Furthermore, several non-abietane diterpenes such as the cassane diterpenes benthaminin 2 (47) (IC 50 [35] and the icetexane diterpenes 8,11,13-icetexatriene-10-hydroxy-11,12,16-triacetoxyl (67) (SC 50 24.8 μg/mL) and 8,11,13-icetexatriene-7,10,11-dihydroxy-12,13-dihydrofuran (50) (SC 50 7.01 μg/mL) from the roots of Premna tomentosa L. [36] have been found to be effective potential scavenging molecules of the DPPH radical.…”

Characterization of nimbidiol as a potent intestinal disaccharidase and glucoamylase inhibitor present inAzadirachta indica(neem) useful for the treatment of diabetes

“…Another new diterpenoid, 15-angeloyloxy-16,17-epoxy-19-kauronic acid along with its known metabolite 16-kauren-19-oic acid isolated from the roots of Chromoleana odorata, exhibited strong α-glucosidase inhibitory activities 38 . Two new icetexane diterpenes-8,11,13-icetexatriene-10-hydroxy,11,12,16-triacetoxyl and 8,11,13-icetexatriene-7,10,11-dihydroxy-12,13-dihydrofuran isolated from the roots of Premna tomentosa displayed intestinal α-glucosidase inhibitory activities 39 . Thus, nimbidiol appears to have broad inhibitory activities on almost all glucosidases involved not only with digestion of starch but also other dietary sugars like sucrose and lactose.…”

Therapeutic Potential of Essential Oils Focusing on Diterpenes

“…() observed an effect on phospholipid membranes by diterpenes obtained from Rosmarinus officinalis that was thought to be the result of changes in the membrane permeability. The most common modes of antioxidant activities are the antiradical (Ayinampudi et al ., ), inhibition of lipid peroxidant (Ortuño et al ., ), and ROS and nitric oxide radical (NO ● ) production (Chen et al ., ). It has also been postulated that for that concentration‐dependent antioxidant and cytotoxic activity of EOs (Bakkali et al ., ) that at low concentrations, EOs show antioxidant activity (cytoprotectivity), while at high concentration, they may act as cytotoxic (pro‐oxidant) agents.…”

“…Diterpenes in diabetic/lipidemia. Three new icetexane diterpenes isolated from Premna tomentosa have antiradical (DPPH • ) activity and also produced αglucosidase activity (Ayinampudi et al, 2012). Otherwise, 16α-hydroxycleroda-3, 13 (14) Z-dien-15, 16-olide Polyalthia longifolia at a dose of 50 mg/kg/day for 8 weeks in C57BL/6 mice exerted antiadipogenic and antiobesity activities (Beg et al, 2015).…”