New horizons in culture and valorization of red microalgae

Gaignard, Clément; Gargouch, Nesrine; Dubessay, Pascal; Delattre, Cédric; Pierre, Guillaume; Laroche, Céline; Fendri, Imen; Abdelkafi, Slim; Michaud, Philippe

doi:10.1016/j.biotechadv.2018.11.014

Cited by 93 publications

(96 citation statements)

References 287 publications

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“…A mucilage made of partly soluble sulfated polysaccharides, which is sometimes non-covalently linked with glycoproteins, encapsulates the cell of red microalgae [24,267]. These polysaccharide layers increase in size on the basis of physicochemical environmental conditions and nutrient starvation, and can reach up to 50-60% of dry matter, which supports the idea that under stress conditions, these microalgae supply and utilize energy to synthesize exocellular sugars to survive.…”

Section: Eps Composition Antioxidant and Scavenging Activity Determinmentioning

confidence: 73%

“…Polysaccharides, and more specifically soluble EPS, which are produced by several prokaryotic and eukaryotic microalgae, are at the center of attention of the academic and industrial communities due to their antioxidant and other novel properties [266,267]. Currently, highly valuable compounds, such as pigments and sulfated polysaccharides for industrial production, are only produced by 10 to 15 microalgae species, whereas other species are still being studied [49,[266][267][268][269]. In fact, metabolism of aerobic organisms, as well as some exogenous agents, produce ROS such as superoxide radicals (O2•¯), singlet oxygen ( 1 O 2 ), hydroxyl radicals (•OH), and hydrogen peroxide (H 2 O 2 ), which are believed to be the origin of some forms of cellular damage such as aging, mutagenesis, and carcinogenesis [270].…”

Section: Exopolysaccharides From Microalgaementioning

confidence: 99%

“…Photoautotrophic microalgae collect and store antioxidative scavenger complexes, such as polysaccharides, to protect their cells from long-time exposure to ROS and other free radicals [264]. Many polysaccharides that are derived from these microorganisms have been recognized as probable antioxidants (Table 5) [264,266,267,271]. Glycosidic linkages, monosaccharide composition, molecular weight, and conformation of antioxidant polysaccharides determine their scavenging activity [272].…”

Section: Exopolysaccharides From Microalgaementioning

confidence: 99%

“…These polysaccharide layers increase in size on the basis of physicochemical environmental conditions and nutrient starvation, and can reach up to 50-60% of dry matter, which supports the idea that under stress conditions, these microalgae supply and utilize energy to synthesize exocellular sugars to survive. Some of the closely studied red microalgae are the strains that belong to the Porphyridium genus [267]. These species naturally inhabit shallow near-shore waters and sea sands, which are accompanied by stress conditions, such as salts, temperature, and light, resulting in ROS formation.…”

Section: Eps Composition Antioxidant and Scavenging Activity Determinmentioning

confidence: 99%

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Marine Bacteria versus Microalgae: Who Is the Best for Biotechnological Production of Bioactive Compounds with Antioxidant Properties and Other Biological Applications?

Hamidi

Kozani

et al. 2019

Marine Drugs

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Natural bioactive compounds with antioxidant activity play remarkable roles in the prevention of reactive oxygen species (ROS) formation. ROS, which are formed by different pathways, have various pathological influences such as DNA damage, carcinogenesis, and cellular degeneration. Incremental demands have prompted the search for newer and alternative resources of natural bioactive compounds with antioxidant properties. The marine environment encompasses almost three-quarters of our planet and is home to many eukaryotic and prokaryotic microorganisms. Because of extreme physical and chemical conditions, the marine environment is a rich source of chemical and biological diversity, and marine microorganisms have high potential as a source of commercially interesting compounds with various pharmaceutical, nutraceutical, and cosmeceutical applications. Bacteria and microalgae are the most important producers of valuable molecules including antioxidant enzymes (such as superoxide dismutase and catalase) and antioxidant substances (such as carotenoids, exopolysaccharides, and bioactive peptides) with various valuable biological properties and applications. Here, we review the current knowledge of these bioactive compounds while highlighting their antioxidant properties, production yield, health-related benefits, and potential applications in various biological and industrial fields.

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Section: Eps Composition Antioxidant and Scavenging Activity Determinmentioning

confidence: 73%

Section: Exopolysaccharides From Microalgaementioning

confidence: 99%

Section: Exopolysaccharides From Microalgaementioning

confidence: 99%

Section: Eps Composition Antioxidant and Scavenging Activity Determinmentioning

confidence: 99%

See 2 more Smart Citations

Marine Bacteria versus Microalgae: Who Is the Best for Biotechnological Production of Bioactive Compounds with Antioxidant Properties and Other Biological Applications?

Hamidi

Kozani

et al. 2019

Marine Drugs

Self Cite

View full text Add to dashboard Cite

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“…Based on the differences in metabolism that each species presents, a possible and feasible approach is to consider that they all have reserves made out of polymers of glucose (glucans), such as chrysolaminarin (1:11), laminarin (3:1) (β-1,3 and β-1,6 branches), paramylon(β-1,3), glycogen-type, cyanophycean, floridean (semiamylopectin: α-1,4 and α-1,6 branches), and amylose-type starch (α-1, 4) or both (Figure 2). The external covering of cell with polysaccharides could be peptidoglycan matrices, cellulosic wall, and galactose polymer matrix, and others [18][19][20].…”

Section: Carbohydrate Importance and Compositionmentioning

confidence: 99%

Concepts and Trends for Extraction and Application of Microalgae Carbohydrates

Souza¹,

Sanchez-Barrios²,

Rizzetti³

et al. 2020

Microalgae - From Physiology to Application

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The proposed chapter aims to provide a more in-depth explanation of the composition of carbohydrates in microalgae biomass, focusing on separation methods, chemistry, molecular characterization, as well as their application in several areas. The purpose of this review chapter is to show that biological products from microalgae have potential in health, food, and industry applications (materials and biofuel production). Steps for extraction and purification will be discussed, as well as the relationship between the type of microalgae and its composition, as a way of optimizing protocol selection and product making, without breaking down the cell to begin with (total carbohydrate extraction present in the cell). An overall overview of the current and prospective trends and methodologies for the use of microalgae carbohydrate will be included as starting points to shed light on some of the possible issues that currently do not allow the development and feasibility of microalgae biorefineries.

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Scale‐down of oxygen and glucose fluctuations in a tubular photobioreactor operated under oxygen‐balanced mixotrophy

Fernández

García

Jansen

et al. 2023

Biotech & Bioengineering

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Oxygen-balanced mixotrophy (OBM) is a novel type of microalgal cultivation that improves autotrophic productivity while reducing aeration costs and achieving high biomass yields on substrate. The scale-up of this process is not straightforward, as nonideal mixing in large photobioreactors might have unwanted effects in cell physiology. We simulated at lab scale dissolved oxygen and glucose fluctuations in a tubular photobioreactor operated under OBM where glucose is injected at the beginning of the tubular section. We ran repeated batch experiments with the strain Galdieria sulphuraria ACUF 064 under glucose pulse feeding of different lengths, representing different retention times: 112, 71, and 21 min. During the long and medium tube retention time simulations, dissolved oxygen was depleted 15-25 min after every glucose pulse. These periods of oxygen limitation resulted in the accumulation of coproporphyrin III in the supernatant, an indication of disruption in the chlorophyll synthesis pathway. Accordingly, the absorption cross-section of the cultures decreased steeply, going from values of 150-180 m 2 kg −1 at the end of the first batch down to 50-70 m 2 kg −1 in the last batches of both conditions. In the short tube retention time simulation, dissolved oxygen always stayed above 10% air saturation and no pigment reduction nor coproporphyrin III accumulation were observed. Concerning glucose utilization efficiency, glucose pulse feeding caused a reduction of biomass yield on substrate in the range of 4%-22% compared to the maximum levels previously obtained with continuous glucose feeding (0.9 C-g C-g −1 ).The missing carbon was excreted to the supernatant as extracellular polymeric substances constituted by carbohydrates and proteins. Overall, the results point out the importance of studying large-scale conditions in a controlled environment and the need for a highly controlled glucose feeding strategy in the scale-up of mixotrophic cultivation.

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New horizons in culture and valorization of red microalgae

Cited by 93 publications

References 287 publications

Marine Bacteria versus Microalgae: Who Is the Best for Biotechnological Production of Bioactive Compounds with Antioxidant Properties and Other Biological Applications?

Marine Bacteria versus Microalgae: Who Is the Best for Biotechnological Production of Bioactive Compounds with Antioxidant Properties and Other Biological Applications?

Concepts and Trends for Extraction and Application of Microalgae Carbohydrates

Scale‐down of oxygen and glucose fluctuations in a tubular photobioreactor operated under oxygen‐balanced mixotrophy

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