New high-resolution wave front sensing ophthalmic technique for the characterization of ocular optics

Bonaque-González, Sergio; Trujillo-Sevilla, Juan M.; Casanova-González, Óscar; Carmona-Ballester, David; Sicilia-Cabrera, Miguel; Ceruso, Sabato; Gaudestad, J.; Rodríguez-Ramos, José Manuel

doi:10.1117/12.2548595

Cited by 3 publications

(4 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1b). Each pixel thus became a data point for phase determination, achieving the highest-resolution aberrometry measurements seen in the field of ophthalmology [28]. As a result, the wavefront phase can be described with extremely high orders of Zernike's polynomials, not yet analyzed to date (Fig.…”

Section: Apparatusmentioning

confidence: 99%

“…When this beam emerges from the eye, it is then redirected and resized by an optical system that corrects for defocus in the range of [-10.00 to ?10.00 D]. After this, the beam is divided into two paths to obtain the intensity image of each plane at both sides of the pupil plane with the use of a camera (termed science camera) [27,28].…”

Section: Apparatusmentioning

confidence: 99%

“…Corneal tomography was performed using the Pentacam HR camera system (Oculus Optikgera ¨te GmbH, Wetzlar, Germany), which obtains cross-sectional images with two rotating Scheimpflug cameras capturing up to 138 000 elevation points. Using these coordinates, a three-dimensional reconstruction of both corneal surfaces is converted into maps for clinical guidance [28][29][30][31]. Zernike coefficients for corneal elevation were obtained for a 6-mm diameter and exported to Zemax software using a dynamic data exchange toolbox.…”

Section: Corneal Aberrationsmentioning

confidence: 99%

See 2 more Smart Citations

Ultra-High Resolution Optical Aberrometry in Patients with Keratoconus: A Cross-Sectional Study

et al. 2023

View full text Add to dashboard Cite

Introduction: This study performs optical aberration assessment in patients using a novel ultra-high-resolution device. The objective of this study is to analyze optical aberrations, especially the very high order wavefront (more than 10th order of Zernike coefficients), and compare between keratoconus and healthy patients. Methods: In this cross-sectional study, we analyzed 43 eyes from 25 healthy patients and 43 eyes from 27 patients with keratoconus using corneal tomography and a very high-resolution (8.55 lm) aberrometer prototype (T-eyede) outfitted with a sensor originally developed for use in the field of astrophysics. Corneal aberration values were assessed using an optical model built with Zemax optical software, while ocular aberrations were assessed using T-eyede. In addition, image-processing analysis was performed of the wavefront phase, creating a highpass filter map. Results: We found lower values for ocular aberrations than corneal aberrations in both groups (p \ 0.001). Specifically, we found a reduction in primary astigmatism (0.145 lm) and primary coma (0.017 lm). Also, the keratoconus group showed significantly higher wavefront aberration values compared with controls (p \ 0.001). An analysis of the highpass filter map revealed 2 contrasting results: one smooth or clear, while the other presented a banding pattern. Almost all in the control group (95%) showed the first pattern, while 77% of the keratoconus group showed a banding pattern on the filtered map (chi-squared test, p \ 0.001). Conclusion: This device provides reliable, precise measurements of ocular aberrations that correlate well with corneal aberrations. Furthermore, the extraordinary high-resolution measurements revealed unprecedented micro changes in the wavefront phase of patients with keratoconus that varied with disease stage. These findings could lead to new screening or follow-up methods.

show abstract

Section: Apparatusmentioning

confidence: 99%

Section: Apparatusmentioning

confidence: 99%

Section: Corneal Aberrationsmentioning

confidence: 99%

See 1 more Smart Citation

Ultra-High Resolution Optical Aberrometry in Patients with Keratoconus: A Cross-Sectional Study

et al. 2023

View full text Add to dashboard Cite

show abstract

“…To overcome this, the WaveFront Phase Imaging (WFPI) sensor has recently been presented in the literature to measure the phase in transparent objects with more resolution than Hartmann-Shack, being previously validated in other technical fields such as silicon metrology 13,14 , optical glass quality assessment 15,16 , and tested in ophthalmology 17 with healthy subjects and keratoconic patients by t•eyede prototype [18][19][20] . In the last work, the authors have demonstrated that this device is capable of reliably distinguishing between healthy and keratoconic eyes by means of the ocular aberrations (Astigmatism, Coma, and High Order Aberrations), besides exposing the relevance of the further orders than 10th by revealing a pattern of folds or bands in advanced keratoconus that have not been seen in phase results previously.…”

Section: Introductionmentioning

confidence: 99%

Clinical applicability of the WaveFront Phase Imaging Sensor in the Keratoconus Disease

Belda-Para,

Velarde-Rodríguez,

Velasco-Ocaña

et al. 2023

Preprint

View full text Add to dashboard Cite

SignificanceThe analysis of the wavefront phase of keratoconus eyes has become increasingly important due to its impact on the assessment of visual quality loss, irrecoverable with conventional optical treatments, and the understanding of morphological changes in corneal structures.AimThe aim of this work is to quantitatively assess the wavefront phase of keratoconic eyes measured by the novel high-resolution ocular aberrometer t·eyede (based on WaveFront Phase Imaging Sensor).ApproachThe measurements with this device were taken on healthy and keratoconic eyes at the Hospital Universitario Fundación Jiménez Díaz (Madrid, Spain). The wavefront phase recovered is post-processed and displayed in different phase maps, using exclusively the high-pass filter map for this study. From this map, the Root Mean Square, the Peak-to-Valley, and the amplitude value of the predominant obtained from its Fourier Transform are the parameters to distinguish between healthy and keratoconic eyes. Furthermore, the banding pattern observed in most keratoconic eyes is quantitatively analyzed by means of its period and orientation calculated from the Fourier Transform.ResultsThe Control group was composed of 43 healthy eyes, and the Pathological group presented 43 keratoconic eyes. Regarding the first three parameters used to compare both groups, there were significant statistical differences between them in all parameters, where the values obtained with the keratoconic group were higher than those of the healthy group. Although the values cannot be statistically comparable between stages, they tended to increase according to the severity of the disease. On the other hand, analyzing the banding pattern, the mean value of the period was approximately 50 µm, and most orientations were obliquus, tending to be horizontal rather than vertical.ConclusionsThe present study demonstrates that the objective analysis of the high frequencies detected by this wavefront sensor is a potential tool to reliably advise in the keratoconus diagnosis. Furthermore, combining this achievement with the quantitative assessment of the banding pattern would be used to objectively monitor the internal corneal status throughout the disease and its treatment optimization and surgery time.

show abstract

Comparing the clinical applicability of wavefront phase imaging in keratoconus versus normal eyes

Belda-Para,

Velarde-Rodríguez,

Velasco-Ocaña

et al. 2024

Sci Rep

View full text Add to dashboard Cite

The aim of this work is to quantitatively assess the wavefront phase of keratoconic eyes measured by the ocular aberrometer t·eyede (based on WaveFront Phase Imaging Sensor), characterized by a lateral resolution of 8.6 µm without requiring any optical element to sample the wavefront information. We evaluated the parameters: root mean square error, Peak-to-Valley, and amplitude of the predominant frequency (Fourier Transform analysis) of a section of the High-Pass filter map in keratoconic and healthy cohorts. Furthermore, we have analyzed keratoconic eyes that presented dark–light bands in this map to assess their period and orientation with the Fourier Transform. There are significant statistical differences (p value < 0.001) between healthy and keratoconic eyes in the three parameters, demonstrating a tendency to increase with the severity of the disease. Otherwise, the quantification of the bands reveals that the width is independent of eye laterality and keratoconic stage as orientation, which tends to be oblique. In conclusion, the quantitative results obtained with t·eyede could help to diagnose and monitor the progression of keratoconus.

show abstract

New high-resolution wave front sensing ophthalmic technique for the characterization of ocular optics

Cited by 3 publications

References 5 publications

Ultra-High Resolution Optical Aberrometry in Patients with Keratoconus: A Cross-Sectional Study

Ultra-High Resolution Optical Aberrometry in Patients with Keratoconus: A Cross-Sectional Study

Clinical applicability of the WaveFront Phase Imaging Sensor in the Keratoconus Disease

Comparing the clinical applicability of wavefront phase imaging in keratoconus versus normal eyes

Contact Info

Product

Resources

About