New hemostatic agent: the effect of Ankaferd Blood Stopper on healing wounds in experimental skin incision model

Abstract

Turkey is of great importance for the biodiversity of genus Onobrychis Adans. and hosts 55 species that are adapted to dry and poor environments. This study was conducted to evaluate 35 Onobrychis taxa in terms of 1000-seed weight, germination percentage, mean germination time, and hard and swollen seeds and to determine the suitability of mechanical scarification for dormancy breaking in species with hard or impermeable seed coats. Seed dormancy was detected in 19 of the investigated species and 14 of the endemic species. Germination percentages of these taxa ranged from 5.5% to 98.0%. The lowest germination rate (5.5%) and the highest hard seed rate (93.0%) were determined in Onobrychis lasiostachya Boiss. Increased germination and decreased hard seed rates were achieved using mechanical scarification with sandpaper in Onobrychis gracilis Besser. Germination of O. lasiostachya, Onobrychis oxyodonta Boiss., and Onobrychis podperae Sirj. increased after mechanical scarification. It was concluded that mechanical scarification is an effective method for improving germination of wild Onobrychis taxa.

Effect of Ankaferd blood stopper® on tendon healing: an experimental study in a rat model of Achilles tendon injury

“…Most of these studies showed negative or ineffective effect on healing process similarly to our study results. In a study, Yüce et al [29] used experimental skin incision model in rabbits. They reported that ABS has negative effect on wound healing in the early periods while it has no negative effect on healing in the late periods.…”

Effects of Ankaferd BloodStopper on dermal healing in diabetic rats

“…ABS has been used as a local haemostatic agent in surgery, but it was also shown to promote healing (5,9). Its effects on soft-tissue healing have been investigated (17,(19)(20)(21), but not in a STZ model of diabetes. Therefore, the aim of the present study was to histologically assess the effects of ABS on collagen 4, blood GSH levels, and LPO to evaluate its potential effects in early-stage soft-tissue healing on STZtreated rats.…”

“…The authors suggested that ABS can be safely used for the repair of full-thickness wounds. Yüce et al also recommended ABS to promote wound healing (19).…”

“…Several studies have shown that ABS promotes tissue healing (5,9,(16)(17)(18)(19)(20)(21). Therefore, in this study, we addressed the effectiveness of ABS in diabetes, in which wound healing is severely impaired.…”

Hemostatic Efficacy of Local “Chitosan Linear Polymer” Granule in an Experimental Sheep Model with Severe Bleeding of Arteria and Vena Femoralis

“…[2,3,7,[18][19][20] While many local hemostatic agents have been tested, no clear consensus exists regarding optimal hemorrhage control strategy for external bleeding. [1,4,8,9,[13][14][15][16][17]20,[24][25][26][27][28][29][30] However, Pusateri and Grissom [10,19] outlined ideal qualities of hemostatic agents for prehospital and battlefield use.…”