New “Guidance” for the Treatment of Hepatic Ischemia Reperfusion Injury Through Semaphorins and Plexins*

Eckle, Tobias

doi:10.1097/ccm.0000000000001699

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…Studies have shown that patients with renal transplantation or renal surgery are likely to be affected by IRI. After renal transplantation, IRI may lead to rejection to cause renal failure, which in turn shortens the survival of patients ( 2 – 4 ). Renal IRI is one of the causes of acute kidney injury.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effect of berberine on renal ischemia-reperfusion injury in rats and its effect on Bax and Bcl-2

Hai-ya

Lei

2018

Exp Ther Med

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This study aimed to investigate the therapeutic effect of berberine on renal ischemia-reperfusion injury in rats and its effect on Bax and Bcl-2. Sixty adult SD rats were randomly divided into four groups: control group A, renal ischemia-reperfusion group B, berberine group C and berberine + exendin-(9–39) treatment group D. In group A, right kidney was resected and left renal pedicle was separated, but left renal artery was not blocked. Renal ischemia-reperfusion model was established in other groups. Rats in group C were not subjected to any treatment after model construction. Rats in group C and D were subjected to intraperitoneal injection of berberine 7 days before the experiment. Besides that, intraperitoneal injection of exendin-(9–39) was performed at day 1 and 4 after model construction. Automatic biochemical analyzer was used to measure serum creatinine (SCr) and blood urea nitrogen (BUN). Malondialdehyde (MDA) in renal cortex was measured by enzyme-linked immunosorbent assay and contents of Bax and Bcl-2 in renal tissue were measured by western blot analysis. Apoptosis of rat renal cells was detected by TUNEL assay. The results showed that levels of SCr, BUN, MDA and Bax were significantly higher in group B than in other groups (P<0.05). Levels of Bcl-2 in group B were significantly higher than those in group A but significantly lower than those in group C and D. Compared with group A, apoptosis of renal cells was more severe in group B. Compared with group B, apoptosis of renal cells was significantly improved in group C and D, but was still more severe than that in group A. In conclusion, berberine can effectively improve renal function in rats with renal ischemia-reperfusion injury by inhibiting Bax expression and promoting Bcl-2 expression.

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Section: Introductionmentioning

confidence: 99%

Therapeutic effect of berberine on renal ischemia-reperfusion injury in rats and its effect on Bax and Bcl-2

Hai-ya

Lei

2018

Exp Ther Med

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“…At the same time, dry hot air can be poured onto the wound surface through the filter sheet. A therapeutic environment in which dry and hot air continuously surrounds the patient is formed [ 19 ].…”

Section: Results and Analysismentioning

confidence: 99%

Application of Multifunctional Intelligent Suspension Treatment Beds in Nursing Care of Patients with Extensive Burns

Chen

et al. 2021

Contrast Media & Molecular Imaging

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The nursing care of patients with extensive burns by using multifunctional intelligent suspension treatment beds was studied. 40 patients, including 30 males and 10 females, with extensive burns were nursed using multifunctional intelligent suspension treatment beds. First of all, the patients were given psychological care, which was patiently explained, so that they can overcome their fears and be treated with peace of mind. Second, the room temperature and bed temperature were closely monitored. Finally, special attention was paid to the adjustment of rehydration volume, regular detection of plasma electrolytes, prevention of electrolyte disorder, and dehydration. Besides, disinfection and isolation should be performed when using. The results showed that 4 cases (20%) were positive in group A and 8 cases (40%) were positive in group B on the 10th day after injury X 2 = 4.005 , and the incidence of wound infection in group A was significantly lower than that in group B. The use of suspension beds in patients with extensive burns makes them safe and comfortable, and the whole body wound scabs healed faster, as well as the infection was minimized. A suspended bed is especially suitable for the clinical treatment of patients with extensive burns. The advantages of suspended bed can be fully realized by summarizing clinical experience.

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New “Guidance” for the Treatment of Hepatic Ischemia Reperfusion Injury Through Semaphorins and Plexins*

Cited by 2 publications

References 11 publications

Therapeutic effect of berberine on renal ischemia-reperfusion injury in rats and its effect on Bax and Bcl-2

Therapeutic effect of berberine on renal ischemia-reperfusion injury in rats and its effect on Bax and Bcl-2

Application of Multifunctional Intelligent Suspension Treatment Beds in Nursing Care of Patients with Extensive Burns

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