New guanidine‐containing nanocomposites impeding the growth of Staphylococcus epidermidis 33 and the biofilm formation

Abstract

New water-soluble nanocomposites (AgNCs) based on Ag and copolymers of 2,2-diallyl-1,1,3,3-tetraethylguanidiniumchloride with N-vinylpyrrolidone [poly(AGC-VP)] and vinylacetate [poly(AGC-VA)] have been developed. Antibacterial action of new silver nanocomposites on S. epidermidis 33 (planctonic cells and biofilms) is reported in this study. AgNCs strongly inhibited biofilms formation of S. epidermidis 33. The viability of S. epidermidis 33 cells in biofilms was considerably reduced by new AgNCs. It has been shown that S. epidermidis 33 inactivation in biofilms occurs at AgNC concentrations > 5 times higher as compared to those inhibiting completely the planktonic cells. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 630-638, 2016.

Guanidinium and Phosphonium Scaffolds Loaded with Silver Nanoparticles: Synthesis, Characterization, In Vitro Assessment of the Antibacterial Potential and Toxicity

“…It was shown that administration of silver compounds in different materials prevented bacterial bio lm formation [58]. The antibio lm activity of silver nanoparticles is brie y described in a number of studies [59][60][61][62][63][64][65][66][67][68]. It has been shown that inactivation of bacteria in bio lms occurs at silver nanoparticle concentrations 5-20 times higher than those inhibiting completely the planktonic cells and bio lm formation [67,68].…”