Silver nanocomposites based on copolymers of N,N-diallyl-N’-acylhydrazines with N-vinylpyrrolidone

Abstract

New nanocomposites based on Ag and copolymers of N-vinylpyrrolidone with N, N-diallyl-N’-acetylhydrazine [poly(VP-DAAH)], N, N-diallyl-N’-butanoylhydrazine [poly(VP-DABH)] and N, N-diallyl-N’-benzoylhydrazine [poly(VP-DABEH)] have been developed. The average silver particle size ranged from 10 to 20 nm for poly(VP-DAAH), from 13 to 21 nm for poly(VP-DABEH) and from 30 to 42 nm for poly(VP-DABH), with the corresponding UV-vis absorption peak position at 400-410 nm. New nanocomposites based on copolymers of N, N-diallyl-N’-acylhydrazines have cytotoxic activity against rhabdomyosarcoma RD and melanoma MS. This effect is comparable to the activity of camptothecin, an alkaloid with high antitumor activity.

Novel Silver Nanocomposites as Effective Antitumor Agents

“…Silver nanocomposites based on DAH and DAAP copolymers have been obtained by the reduction of AgNO 3 with NaBH 4 in copolymer solution. [25][26][27] Reaction proceeds via formation of the stable dark brown sols, from which silver nanocomposites were separated by dialysis. The use of DAH copolymers with sulfur dioxide does not lead to the formation of nanoparticles.…”

Phosphorous-containing copolymers loaded with silver nanoparticles for biomedical purposes

“…It is known that the stability of particles is significantly affected by the chemical structure of the polymer [6]. A large number of studies were devoted to the use of (co)polymers of N-vinylpyrrolidone (VP) as a nanostabilizing matrices [7][8][9][10][11][12].…”