New GnRH analogs in canine reproduction

Gobello, Cristina

doi:10.1016/j.anireprosci.2006.08.024

Cited by 43 publications

(49 citation statements)

References 35 publications

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“…Another GnRH agonist, leuprolide, found effective in suppressing reproduction for one breeding season in wapiti (Cervus elaphus; Baker et al 2002;Conner et al 2007) and female mule deer (Odocoileus hemionus; Baker et al 2004), has not been used more recently. The effectiveness of GnRH agonists depends on agonist type, release system, dose rate and duration of treatment (Gobello 2007;Patton et al 2007). The side effects of GnRH agonists are similar to those associated with gonad removal, but are reversible and there are no known effects on lactation (Asa and Porton 2005).…”

Section: Hormonal Methodsmentioning

confidence: 99%

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Fertility control to mitigate human–wildlife conflicts: a review

2014

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Abstract. As human populations grow, conflicts with wildlife increase. Concurrently, concerns about the welfare, safety and environmental impacts of conventional lethal methods of wildlife management restrict the options available for conflict mitigation. In parallel, there is increasing interest in using fertility control to manage wildlife. The present review aimed at analysing trends in research on fertility control for wildlife, illustrating developments in fertility-control technologies and delivery methods of fertility-control agents, summarising the conclusions of empirical and theoretical studies of fertility control applied at the population level and offering criteria to guide decisions regarding the suitability of fertility control to mitigate human-wildlife conflicts. The review highlighted a growing interest in fertility control for wildlife, underpinned by increasing numbers of scientific studies. Most current practical applications of fertility control for wild mammals use injectable single-dose immunocontraceptive vaccines mainly aimed at sterilising females, although many of these vaccines are not yet commercially available. One oral avian contraceptive, nicarbazin, is commercially available in some countries. Potential new methods of remote contraceptive delivery include bacterial ghosts, virus-like particles and genetically modified transmissible and non-transmissible organisms, although none of these have yet progressed to field testing. In parallel, new species-specific delivery systems have been developed. The results of population-level studies of fertility control indicated that this approach may increase survival and affect social and spatial behaviour of treated animals, although the effects are species-and context-specific. The present studies suggested that a substantial initial effort is generally required to reduce population growth if fertility control is the sole wildlife management method. However, several empirical and field studies have demonstrated that fertility control, particularly of isolated populations, can be successfully used to limit population growth and reduce human-wildlife conflicts. In parallel, there is growing recognition of the possible synergy between fertility control and disease vaccination to optimise the maintenance of herd immunity in the management of wildlife diseases. The review provides a decision tree that can be used to determine whether fertility control should be employed to resolve specific human-wildlife conflicts. These criteria encompass public consultation, considerations about animal welfare and feasibility, evaluation of population responses, costs and sustainability.

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Section: Hormonal Methodsmentioning

confidence: 99%

“…stimulates oestrus in females and temporarily enhances testosterone and semen production in males (Patton et al 2007). Because agonists do not quickly dissociate from the GnRH receptors, the 'flare up' is followed by prolonged ovarian quiescence and infertility (Gobello 2007).…”

Section: Hormonal Methodsmentioning

confidence: 99%

Fertility control to mitigate human–wildlife conflicts: a review

2014

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“…Prolonged administration of GnRH agonists leads to desensitization of the pituitary gland and effectively inhibited the pituitarygonadal axis 2,16 . However, treatment with GnRH agonists initially induces a large increase in the concentrations of LH and FSH (flare-up effect) that is sometimes associated with estrus induction, with or without ovulation 6,12 .…”

Section: Discussionmentioning

confidence: 99%

“…Bitches exhibit different responses to administration of deslorelin implants depending on the stage of the estrus cycle. A sharp, initial stimulatory gonadotropin response to GnRH agonist treatment known as 'flare-up' occurs after implant insertion which results in an increased release of FSH and LH 15,16 . In dogs, estrus can be induced within 3 to 10 days after treatment 2,6,17 .…”

Section: Introductionmentioning

confidence: 99%

Clinical and Endocrine Short-Term Effects of GnRH Analogue Deslorelin in Prepubertal Bitches: Does A “Flare-up” Occur?

Kaya¹,

Aslan²,

Kaya³

et al. 2013

Kafkas Univ Vet Fak Derg

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SummaryLong-acting GnRH agonists have been used both in canine estrus induction and prevention. The objective of the study was to investigate the clinical and endocrine short-term effects of a deslorelin implant (4.7 and 9.4 mg) in terms of initial "flare-up" in prepubertal bitches. Fourteen healthy, cross-breed prepubertal female dogs, aged 4 months, were used in the study. An implant containing 9.4 mg (G1, n=5) and 4.7 mg (G2, n=4) deslorelin (Suprelorin®) or a placebo (sodium chloride 0.9%, G3, n=5) was inserted subcutaneously. Estrus was monitored once daily by physical and sexual behavioral changes. Vaginal cytology, serum progesterone (P4) and estradiol 17β (E2) concentrations were monitored weekly for the first five weeks throughout the treatment. None of the bitches in the treatment (G1 and G2) and control (G3) group showed any signs of estrous throughout the study period. No local reactions were observed at the implantation site. Two bitches showed an increase in serum P4 concentrations (>1.0 ng/ml) in G1 (2/5; 40%), however, only one of these two animals (P4=6.37 ng/ml) showed an increase in serum E2 concentrations up to 37 pg/ml. No marked increase in serum P4 and E2 concentrations were observed during the first 13 weeks of treatment in G2. These data demonstrate that in prepubertal bitches, insertion of a deslorelin implant does not cause a "flare-up effect" which commonly occurs in anestrus adult bitches during the first month after implantation. However, further studies are needed to demonstrate that the "flare-up" effect of deslorelin implant in bitches especially during later prepubertal stages. Keywords: Prepubertal bitches, Suprelorin®, Flare-up effect Prepubertal Köpeklerde GnRH Analoğu Deslorelinin Kısa DönemKlinik ve Endokrinolojik Etkileri: "Flare-up" Gözlenir mi? ÖzetUzun etkili GnRH agonistleri köpeklerde hem östrusun uyarılmasında hem de baskılanmasında kullanılmaktadırlar. Bu çalışmada, pubertas öncesi dönemdeki dişi köpeklerde deslorelin implant (4.7 ve 9.4 mg) kullanımının "flare-up" dönemi olarak değerlendirilebilecek klinik ve endokrinolojik kısa dönem etkilerinin varlığı araştırılmıştır. Bu amaçla pubertas öncesi dönemde olduğu belirlenen ortalama 4 aylık yaşta on dört adet sağlıklı melez dişi kopek kullanıldı. Köpeklere deri altı yolla 9.4 mg (G1, n=5) ve 4.7 mg (G2, n=4) deslorelin (Suprelorin®) etken maddesi içeren implantlar ya da plasebo (sodyum klorür %0.9; G3; n=5) uygulandı. Östrus belirtileri günlük olarak fiziksel değişiklikler ve davranış değişiklikleri yönünden takip edildi. Ayrıca çalışma süresince vaginal sitoloji, serum progesteron (P4) ve östradiol 17β (E2) konsantrasyonları haftalık olarak izlendi. Tedavi (G1 ve G2) ve kontrol grubundaki (G3) hayvanların hiçbirinde östrus bulgusu belirlenmedi. İmplantın yerleştirildiği bölgede herhangi bir lokal yan etki gözlenmedi. Grup 1'de iki köpekte (2/5; %40) serum P4 düzeyinde bir artış gözlenirken, bu köpeklerden yalnızca birinde (P4=6,37 ng/ml) serum E2 düzeyinin 37 pg/ml'ye kadar yükseldiği belirlendi. Grup 2'de 13 haftal...

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“…Because the use of those drugs are more diffi cult due to their side eff ects such as breast tumors, pyometra, acromegalic changes, diabetes, adrenocorti cal suppression, masculinity in female fetuses, local skin reacti ons, bradycardia, hypersalivati on and vomiti ng, GnRH agonists (desloreline, nafareline), which indirectly suppress the secreti on of LH and FSH, are frequently used to suppress cyclic acti vity in bitches [12][13][14][15] . In bitches, LH is necessary as a luteotropic hormone for the luteal secreti on of P4 throughout pregnancy…”

Section: 6-12mentioning

confidence: 99%

Köpeklerde Gebeliğin Sonlandırılması Amacıyla GnRH Agonisti (Desloreline) ile PGF2Kombinasyonunun Kullanımı

Güngör¹,

Kaya²,

Gürbulak³

et al. 2009

Kafkas Univ Vet Fak Derg

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SummaryTen bitches whose sexual cycle periods were determined with vaginal cytology to be mated at appropriate time were used in this study. Desloreline implant (Suprelorin®) was inserted under the dorsal skin of bitches that were determined to be pregnant using ultrasonography 20 days after the first day of mating. Ten days after the implant insertion, single dose PGF2 (cloprostenol, 20 μg/kg, IM) was administered. The pregnancy was terminated on all bitches that received this procedure. It was determined that the level of progesterone decreased from an average of 28.87±11.86 ng/ml on the day of implant insertion (day 20-21 of pregnancy) to 0.43±0.31 ng/ml when the abortion was completed. It was observed that after the implant insertion, the abortion was completed in an average of 3.9±0.7 days following PGF2 administration. It has been observed that abortions was completed in an average of 2,3±0.48 days after the first vaginal discharge was seen. In conclusion, it was determined that Desloreline, a GnRH agonist, successfully could terminate pregnancy when it is combined with a single dose of PGF2 administration in bitches.Keywords: Bitch, Pregnancy termination, Desloreline, PGF2 Köpeklerde Gebeliğin Sonlandırılması Amacıyla GnRH Agonisti (Desloreline) ile PGF2Kombinasyonunun Kullanımı ÖzetAraştırmada seksüel siklus evresi vaginal sitoloji ile belirlenerek en uygun zamanda çiftleştirilen on dişi köpek kullanıldı. İlk çiftleştirme gününü takiben 20. günden itibaren yapılan ultrases muayenesi ile gebe olduğu belirlenen köpeklere Suprelorin® boyun derisi altına yerleştirildi. İmplantın yerleştirilmesini takiben 10. günde bir kereye mahsus olmak üzere PGF2 (cloprostenol, 20 μg/kg,) kas içi yolla uygulandı. Uygulama yapılan köpeklerin tümünde gebelik sonlandı. Progesteron değerinin implantın uygulandığı gün (gebeliğin 20-21. günü), ortalama 28.87±11.86 ng/ml iken, abortion tamamlandığında ortalama 0.43±0.31 ng/ml'ye düştüğü belirlendi. İmplant uygulamasından 10 gün sonra enjekte edilen PGF2'yı takiben ortalama 3.9±0,7 günde köpeklerde abortionun tamamlandığı görüldü. Abortionun vajinal akıntının ilk kez görülmesinden sonra 2.3±0.48 gün içinde tamamlandığı belirlendi. Sonuç olarak, uzun etkili GnRH anoloğu olan Deslorelin'in köpeklerde tek doz PGF2 uygulaması ile birlikte kombine edildiğinde gebeliği başarılı olarak sonlandırabildiği belirlendi

show abstract

New GnRH analogs in canine reproduction

Cited by 43 publications

References 35 publications

Fertility control to mitigate human–wildlife conflicts: a review

Fertility control to mitigate human–wildlife conflicts: a review

Clinical and Endocrine Short-Term Effects of GnRH Analogue Deslorelin in Prepubertal Bitches: Does A “Flare-up” Occur?

Köpeklerde Gebeliğin Sonlandırılması Amacıyla GnRH Agonisti (Desloreline) ile PGF2Kombinasyonunun Kullanımı

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