New Functions of Old Drugs: Aureolic Acid Group of Anti-Cancer Antibiotics and Non-Steroidal Anti-Inflammatory Drugs

Chakraborty, Hirak; Devi, Pukhrambam Grihanjali; Sarkar, Munna; Dasgupta, Dipak

doi:10.1016/b978-0-12-803961-8.50001-4

Cited by 7 publications

(7 citation statements)

References 185 publications

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“…Pyrazole is a 5-membered heterocyclic aromatic compound that is present in several notable drugs, principal amongst them being celecoxib (Celebrex ® , a nonsteroidal antiinflammatory drug-NSAID, Figure 14) [48]. Meanwhile, pyranopyrazoles are molecules with a pyran ring fused to a pyrazole ring.…”

Section: Pyrazolesmentioning

confidence: 99%

Recent Advances in Multicomponent Reactions Catalysed under Operationally Heterogeneous Conditions

Bosica

Abdilla

2022

Catalysts

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Multicomponent reactions (MCRs) have been gaining significance and attention over the past decade because of their ability to furnish complex products by using readily available and simple starting materials while simultaneously eliminating the need to separate and purify any intermediates. More so, most of these products have been found to exhibit diverse biological activities. Another paradigm shift which has occurred contemporarily is the switch to heterogeneous catalysis, which results in additional benefits such as the reduction of waste and an increase in the safety of the process. More importantly, it allows the user to recover and reuse the catalyst for multiple runs. In summary, both methodologies adhere to the principles of green chemistry, a philosophy which needs to become overarchingly enshrined. The plethora of reactions and catalysts which have been developed gives hope that chemists are slowly changing their ideology. As a result, this review attempts to discuss multicomponent reactions catalysed by operationally heterogeneous catalysts in the past 10 years. In this review, a further distinction is made between the MCRs which lead to the formation of heterocycles and those which do not.

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Section: Pyrazolesmentioning

confidence: 99%

Recent Advances in Multicomponent Reactions Catalysed under Operationally Heterogeneous Conditions

Bosica

Abdilla

2022

Catalysts

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“…Â çàâèñèìîñòè îò ìèøåíè âîçäåéñòâèÿ, ìåõàíèçìû äåéñòâèÿ àíòèáèîòèêîâ ãðóïïû ÀÊ ìîãóò áûòü óñëîâíî ðàçäåëåíû íà 5 ãðóïï, âêëþ÷àÿ: ñâÿçûâàíèå ñ ÄÍÊ; ñâÿçûâàíèå ñ èîíàìè ìåòàëëîâ; âëèÿíèå íà ïðîíèöàåìîñòü ìåìáðàí; ñâÿçûâàíèå ñ áåëêàìè; âîçäåéñòâèå íà êîìïëåêñû ÄÍÊ -áåëîê [83]. Â ñâîþ î÷åðåäü ñîâîêóïíîñòü è/èëè ñåëåêòèâíîñòü âçàèìîäåéñòâèÿ àíòèáèîòèêà ãðóïïû ÀÊ íà òó èëè èíóþ ìèøåíü îïðåäåëÿåò òåðàïåâòè÷åñêèé ïîòåíöèàë ñîåäèíåíèÿ (òàáëèöà).…”

Section: çàêëþ÷åíèåunclassified

Оливомицин А — Противоопухолевый Антибиотик Группы Ауреоловой Кислоты (Обзор)

Тевяшова¹

2016

Хим.-фарм. ж.

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“…Chromomycin A3 has antitumor activity, reversibly binding to minor DNA grooves by interacting with cytosine and guanine (CG)-rich DNA regions in the presence of Mg2+, preventing replication and transcription (SUKANYA CHAKRABARTI1;BHATTACHARYYA, 2000;CHAKRABORTY et al, 2014). Guimarães et al, (2014) showed chromomycin A2 induces autophagy in metastatic melanoma cells, MALME-3M.…”

Section: Introductionmentioning

confidence: 99%

Chromomycin A₅ induces bonafide immunogenic cell death in metastatic melanoma

Florêncio

Edson

Pinto

et al. 2021

Preprint

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Some first-line cytotoxic chemotherapics, e.g. doxorubicin, paclitaxel and oxaliplatin, induce activation of the immune system through immunogenic cell death (ICD). Tumor cells undergoing ICD function as a vaccine, releasing damage-associated molecular patterns (DAMPs), which act as adjuvants, and neoantigens of the tumor are recognized as antigens. ICD induction is rare, however it yields better and long-lasting antitumor responses to chemotherapy. Advanced metastatic melanoma (AMM) is incurable for more than half of patients. The discovery of ICD inducers against AMM is an interesting drug discovery strategy with high translational potential. Here we evaluated ICD induction of four highly cytotoxic chromomycins A (CA5-8). B16-F10, a metastatic melanoma cell line, treated with CA5-8 and doxorubicin exhibited ICD features such as autophagy and apoptosis, externalization of calreticulin, and releasing of HMGB1. However, CA5-treated cells had the best profile, also inducing ATP release, ERp57 externalization, phosphorylation of eIF2a and altering expression of transcription of genes related to autophagy, endoplasmic reticulum stress, and apoptosis. Bonafide ICD induction by CA5 was confirmed by a C57BL/6 mice vaccination assay with CA5-treated cells. These findings support a high potential of CA5 as an anticancer candidate against AMM.

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New Functions of Old Drugs: Aureolic Acid Group of Anti-Cancer Antibiotics and Non-Steroidal Anti-Inflammatory Drugs

Cited by 7 publications

References 185 publications

Recent Advances in Multicomponent Reactions Catalysed under Operationally Heterogeneous Conditions

Recent Advances in Multicomponent Reactions Catalysed under Operationally Heterogeneous Conditions

Оливомицин А — Противоопухолевый Антибиотик Группы Ауреоловой Кислоты (Обзор)

Chromomycin A₅ induces bonafide immunogenic cell death in metastatic melanoma

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New Functions of Old Drugs: Aureolic Acid Group of Anti-Cancer Antibiotics and Non-Steroidal Anti-Inflammatory Drugs

Cited by 7 publications

References 185 publications

Recent Advances in Multicomponent Reactions Catalysed under Operationally Heterogeneous Conditions

Recent Advances in Multicomponent Reactions Catalysed under Operationally Heterogeneous Conditions

Оливомицин А — Противоопухолевый Антибиотик Группы Ауреоловой Кислоты (Обзор)

Chromomycin A5 induces bonafide immunogenic cell death in metastatic melanoma

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Chromomycin A₅ induces bonafide immunogenic cell death in metastatic melanoma