New Formulations of Polysaccharide-Based Hydrogels for Drug Release and Tissue Engineering

Abstract

Polysaccharide-based hydrogels are very promising materials for a wide range of medical applications, ranging from tissue engineering to controlled drug delivery for local therapy. The most interesting property of this class of materials is the ability to be injected without any alteration of their chemical, mechanical and biological properties, by taking advantage of their thixotropic behavior. It is possible to modulate the rheological and chemical-physical properties of polysaccharide hydrogels by varying the cross-linking agents and exploiting their thixotropic behavior. We present here an overview of our synthetic strategies and applications of innovative polysaccharide-based hydrogels: hyaluronan-based hydrogel and new derivatives of carboxymethylcellulose have been used as matrices in the field of tissue engineering; while guar gum-based hydrogel and hybrid magnetic hydrogels, have been used as promising systems for targeted controlled drug release. Moreover, a new class of materials, interpenetrating hydrogels (IPH), have been obtained by mixing various native thixotropic hydrogels. OPEN ACCESSGels 2015, 1 4

Tissue engineering of collagen scaffolds crosslinked with plant based polysaccharides

“…A wide variety of polysaccharides available from natural resources can be used in combination with natural and synthetic biopolymers or inorganic material for adhesion, growth or differentiation of cells (Mano et al 2007 ; Bacakova et al 2014 ). Not all polysaccharides have been found suitable but starch, cellulose, chitin, chitosan, guar gum, alginate, agar, glycose-amineglycans, carboxy methylcellulose are some of the polysaccharides reported in designing scaffolds for various cell types (Camponeschi et al 2015 ; Tiwari et al 2019 ; Silva et al 2015 ; Edgar et al 2016 ).…”

Oxythiamine improves antifungal activity of ketoconazole evaluated in canine Malassezia pachydermatis strains

“…The hydrogel formulations designed for this study exhibited fair thixotropic features which enabled them to restore their structure to the previous state after removal of the mechanical force (e.g. after application to the mouse skin) and also enabled them to maintain drug concentration at the site of application . It is possible that the stronger bioadhesiveness noted for hydrogels 5 and 6 was caused by the higher concentration of OT in combination with KTC, resulting in better interaction between the hydrogels and mouse skin or cellulose discs.…”

Polysaccharide-Based Systems for Targeted Stem Cell Differentiation and Bone Regeneration

“…Polymeric, ceramic, and hybrid systems are also used in drug and growth factor delivery, since they can be tuned in order to release substances in a controlled way. However, the extent of sustaining drug release always depends on the individual drug, the material, the release medium used, and the desired effect the drug or factor should have [51,65,67,68].…”