New Flavanones from the Leaves of Cryptocarya chinensis and Their Antituberculosis Activity

Abstract

Four new flavanones, cryptoflavanones A-D (1-4, resp.), together with eight known compounds, were isolated from the leaves of Cryptocarya chinensis. The structures of these new compounds were determined by spectral analyses. Among the isolated compounds, pinocembrin (5) and cryptocaryone (6) exhibited antituberculosis activity against Mycobacterium tuberculosis H(37) Rv strain in vitro with MIC values of 3.5 and 25.0 μg/ml, respectively.

TIPdb: A Database of Anticancer, Antiplatelet, and Antituberculosis Phytochemicals from Indigenous Plants in Taiwan

“…The biological activities of a total of 99 indigenous species, including 29 endemic and 3 naturalized species, are curated into the database, with 5243 records of anticancer, antiplatelet, and antituberculosis activities, respectively. The curated data includes the recent isolated antitubercular flavonoids with promising minimal inhibitory concentration (MIC) [9, 10]. With the emerging prevalence of multidrug-resistant tuberculosis and lack of effective treatments [11, 12], these phytochemicals are especially valuable sources serving as promising candidates and/or QSAR skeletons for novel antituberculosis drugs development.…”

Plants: A Source for New Antimycobacterial Drugs

“…Two new flavonones, pinocembrin (24) and cryptocaryone (25), from the leaves of Cryptocarya chinensis Hemsl., Lauraceae, were effective against M. tuberculosis H37Rv. Among the two compounds, 24 was more active than EMB (MIC 6.25 µg/mL) and the latter was found to be moderatively active [18]. Dorstenia barteri Bureau., Moraceae, a small herb from most regions of tropical South America, contains active phytochemicals against bacteria and fungi.…”

“…Adhatoda vasica Ness., Acanthaceae, which is used in the treatment of colds, cough, and other respiratory disorders, contains antimicrobial compounds. Alkaloids present in the hexane extract like vasicine acetate (1) and 2-acetyl ben- [21] dihydroguaiaretic acid (50 µg/mL) (12.5-50 µg/mL) [28] pisonin B (25 µg/mL) [32] falcarindiol (26.7 µg/mL) [65] 2′-nortiliacorinine and tiliacorine (3.1 µg/mL) (3.1 µg/mL) [12] pinocembrin (3.5 µg/mL) [18] (E)-3,2′,4′-trihydroxy-3′-methoxychalcone (174.8 µM) [21] 4-epi-larreatricin (50 µg/mL) (25 µg/mL) [28] [33] licarin A (25 µg/mL) (3.12-12.5 µg/mL) [42] linoleic acid and oleic acid (100 µg/mL) (100 µg/mL) [46] 1,3 dimethoxy-2-methyl-5-pentyl benzene (≤ 2.5 µg/mL) [66] 13′-bromo-tiliacorinine (3.1-6.2 µg/mL) (1.5-3.1 µg/mL) [12] kanzanol C, 4-hydroxylonchocarpin, stipulin, and amentoflavone (9.76 -> 39.06 µg/mL) [19] aminoacetate derivative of diospyrin (> 10 -≤ 50 µg/mL) (> 10 -≤ 50 µg/mL) [34] licarin B (50 µg/mL) (12.5-50 µg/mL) [42] undecanal (100 µg/mL) (50-200 µg/mL) [46] 3-methoxy-2-methyl-5-pentyl phenol (≤ 2.58 µg/mL) [66] Mauritine M (IC 50 − 72.8 µM) [13] genistein (35 µg/ml) [20] diospyrin (100 µg/mL) (100 µg/mL) [34] eupomatenoid-7…”

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“…was identified to have various flavonoid glycosides and showed moderate activity with a MIC of 128 μg/mL. [17] Pinocembrin and cryptocaryone, two new flavonoids from Cryptocarya chinensis Hemsl. leaves were effective against M. tuberculosis.…”