New, fast corroding high ductility Mg–Bi–Ca and Mg–Bi–Si alloys, with no clinically observable gas formation in bone implants

Remennik, Sergei; Bartsch, Ivonne; Willbold, Elmar; Witte, Frank; Shechtman, D.

doi:10.1016/j.mseb.2011.07.011

Cited by 84 publications

(35 citation statements)

References 16 publications

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“…Magnesium-based alloys were manufactured, containing different amounts of specific chemical elements, particularly rare earth elements, calcium, zinc and aluminum. By means of alloying with these elements and various hot working methods, an adaption of the magnesium´s corrosion and mechanical properties to the host tissue´s needs could be achieved [9][10][11][12][13][14][15]. A reduction or even avoidance of undesired stress shielding effects [16][17][18] is realized due to the occurring degradation process of magnesium over time.…”

Section: Introductionmentioning

confidence: 99%

In vivo evaluation of a magnesium-based degradable intramedullary nailing system in a sheep model

et al. 2015

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Section: Introductionmentioning

confidence: 99%

In vivo evaluation of a magnesium-based degradable intramedullary nailing system in a sheep model

et al. 2015

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“…When Mg‐based implants are exposed to a biological environment, they lose their functionality by deterioration of their mechanical performance before the bone tissue is fully restored. Furthermore, by‐products of profuse Mg dissolution, including hydrogen bubbles and hydroxide ions, can be hazardous to the host tissue, inducing alkaline poisoning and tissue necrosis …”

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite‐coated magnesium implants with improved in vitro and in vivo biocorrosion, biocompatibility, and bone response

Kim

Lee

et al. 2013

J Biomedical Materials Res

102

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Magnesium and its alloys are candidate materials for biodegradable implants; however, excessively rapid corrosion behavior restricts their practical uses in biological systems. For such applications, surface modification is essential, and the use of anticorrosion coatings is considered as a promising avenue. In this study, we coated Mg with hydroxyapatite (HA) in an aqueous solution containing calcium and phosphate sources to improve its in vitro and in vivo biocorrosion resistance, biocompatibility and bone response. A layer of needle-shaped HA crystals was created uniformly on the Mg substrate even when the Mg sample had a complex shape of a screw. In addition, a dense HA-stratum between this layer and the Mg substrate was formed. This HA-coating layer remarkably reduced the corrosion rate of the Mg tested in a simulated body fluid. Moreover, the biological response, including cell attachment, proliferation and differentiation, of the HA-coated samples was enhanced considerably compared to samples without a coating layer. The preliminary in vivo experiments also showed that the biocorrosion of the Mg implant was significantly retarded by HA coating, which resulted in good mechanical stability. In addition, in the case of the HA-coated implants, biodegradation was mitigated, particularly over the first 6 weeks of implantation. This considerably promoted bone growth at the interface between the implant and bone. These results confirmed that HA-coated Mg is a promising material for biomedical implant applications.

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“…In the past decade, countless studies have been performed to control and optimize the mechanical and corrosion properties of magnesium-based alloys (6)(7)(8)(9), which, thanks to their degradation in the physiological environment, could overcome the limitations of inert implant materials and shift the paradigm of conventional bone fixation devices toward new horizons. Driven by these new possibilities, important findings regarding, among others, the degradation mechanism of Mg-based alloys (10,11), the formation of corrosion protective layers by degradation products (12,13), and the osteogenetic properties of Mg ions (14,15) have been reported in the literature. However, such findings are based on the observation of degradation products and of bone healing at the macroscale level.…”

mentioning

confidence: 99%

Long-term clinical study and multiscale analysis of in vivo biodegradation mechanism of Mg alloy

Lee

Han

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

352

236

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There has been a tremendous amount of research in the past decade to optimize the mechanical properties and degradation behavior of the biodegradable Mg alloy for orthopedic implant. Despite the feasibility of degrading implant, the lack of fundamental understanding about biocompatibility and underlying bone formation mechanism is currently limiting the use in clinical applications. Herein, we report the result of long-term clinical study and systematic investigation of bone formation mechanism of the biodegradable Mg-5wt%Ca-1wt%Zn alloy implant through simultaneous observation of changes in element composition and crystallinity within degrading interface at hierarchical levels. Controlled degradation of Mg-5wt%Ca-1wt%Zn alloy results in the formation of biomimicking calcification matrix at the degrading interface to initiate the bone formation process. This process facilitates early bone healing and allows the complete replacement of biodegradable Mg implant by the new bone within 1 y of implantation, as demonstrated in 53 cases of successful long-term clinical study.biodegradable implant | bone formation | clinical application T he century-old concept of the fixation device that holds the fractured bones in place to allow repair through the natural bone remodeling process is still being practiced today without alteration (1-5). The recent rapid growth of the elderly demographic of physically active adults has tremendously intensified the occurrence of bone trauma cases, highlighting once again the major drawbacks of current surgical approaches and osteosynthesis systems, such as inevitable secondary surgery to remove the inert fixation devices after complete bone healing and inflammatory response due to the release of metal ions. In the past decade, countless studies have been performed to control and optimize the mechanical and corrosion properties of magnesium-based alloys (6-9), which, thanks to their degradation in the physiological environment, could overcome the limitations of inert implant materials and shift the paradigm of conventional bone fixation devices toward new horizons. Driven by these new possibilities, important findings regarding, among others, the degradation mechanism of Mg-based alloys (10, 11), the formation of corrosion protective layers by degradation products (12, 13), and the osteogenetic properties of Mg ions (14, 15) have been reported in the literature. However, such findings are based on the observation of degradation products and of bone healing at the macroscale level. Due to lack of fundamental understanding on biocompatibility and underlying bone formation mechanism of the degradation product, there is so far only one known case of statistically insignificant clinical study result (16) with a short-term follow-up. In our previous study, we reported successful development and long-term in vivo study of uniformly slowly degrading Mg-5wt%Ca-1wt%Zn alloy system (SI Appendix, Figs. S1 and S2) featuring adequate mechanical strength [ultimate tensile strength (UTS) ∼250 MPa] (17) a...

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New, fast corroding high ductility Mg–Bi–Ca and Mg–Bi–Si alloys, with no clinically observable gas formation in bone implants

Cited by 84 publications

References 16 publications

In vivo evaluation of a magnesium-based degradable intramedullary nailing system in a sheep model

In vivo evaluation of a magnesium-based degradable intramedullary nailing system in a sheep model

Hydroxyapatite‐coated magnesium implants with improved in vitro and in vivo biocorrosion, biocompatibility, and bone response

Long-term clinical study and multiscale analysis of in vivo biodegradation mechanism of Mg alloy

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