2015
DOI: 10.1016/j.actbio.2015.07.025
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In vivo evaluation of a magnesium-based degradable intramedullary nailing system in a sheep model

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Cited by 84 publications
(96 citation statements)
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References 104 publications
(128 reference statements)
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“…Thus, the increased callus formation mediated by intramedullary Mg2Ag implants during fracture healing in mice is probably due to both an increase in bone formation and a decrease in bone resorption. These findings therefore strongly suggest the suitability of degradable Mg2Ag implants to promote long bone fracture healing in mice and are consistent with studies reporting positive effects of Mg implants on osteoblasts and bone formation [12][13][14]31,36,37]. However, we also noticed that Mg2Ag implants caused alterations of the shape of long bones under non-fracture and fracture conditions.…”
Section: Discussionsupporting
confidence: 79%
“…Thus, the increased callus formation mediated by intramedullary Mg2Ag implants during fracture healing in mice is probably due to both an increase in bone formation and a decrease in bone resorption. These findings therefore strongly suggest the suitability of degradable Mg2Ag implants to promote long bone fracture healing in mice and are consistent with studies reporting positive effects of Mg implants on osteoblasts and bone formation [12][13][14]31,36,37]. However, we also noticed that Mg2Ag implants caused alterations of the shape of long bones under non-fracture and fracture conditions.…”
Section: Discussionsupporting
confidence: 79%
“…During the degradation process, these alloying elements can form complexes in the direct implant environment or distribute systemically via the circulation. Accumulation predominantly occurs in the excretory organs (liver and kidney), but the spleen can also be affected . Therefore, systemic toxicity, as well as local effects, must be considered during biocompatibility testing of new degradable materials.…”
Section: In Vivo Testing Of Magnesium Alloysmentioning
confidence: 99%
“…For orthotopic implant locations, the rat is superior, due to its size and consequent applicability of implant material in bony structures. When more complex, patient adapted implants, like plate screw systems, interlocked intramedullary nailing systems or intranasal stents, are the focus of interest, a larger animal model can be necessary, as production engineering and applicability might be limited in miniaturized devices, and the geometry will be more comparable to the later target application, which is predominately in humans. Another advantage of large animal models like the sheep and pig is their lower metabolism compared to mice and rats, which is also more comparable to humans.…”
Section: In Vivo Testing Of Magnesium Alloysmentioning
confidence: 99%
“…The gas pockets around implantable devices were observed in human patients 14 as well as animal models. 17,19,48,49 Several papers studied the effects of surface modifications on the gas pocket formation. Fischerauer et al observed decrease in the gas pocket formation in the 1st 2 weeks postimplantation with the implants treated by micro-arc oxidation, however these differences were not significant and at weeks 3 and 4 the gas volume was higher than in the untreated group.…”
Section: Discussionmentioning
confidence: 99%