New EMPIR project – Metrology for Drug Delivery

Batista, Elsa; Furtado, Andreia; Pereira, J.; Ferreira, Maria do Céu; Bissig, Hugo; Graham, Emmelyn M.; Niemann, Anders; Timmerman, Annemoon; Sousa, João A.; Ogheard, Florestan; Boudaoud, A.W.

doi:10.1016/j.flowmeasinst.2020.101716

Cited by 20 publications

(4 citation statements)

References 9 publications

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“…An uncertainty of 1% (k = 2) or better was expected for steady flow rates, whereas for fast changing flow rates an uncertainty of 2% (k = 2) or better was expected. The project investigated different flow rate regimes, liquid mixing behaviour and occlusion phenomena in multi-infusion systems with the purpose of improving dosing accuracy in each infusion line [4].…”

Section: Introductionmentioning

confidence: 99%

Intercomparison of micro-liquid flow standard system in APMP

Lee¹,

Zeng²,

Tsai³

et al. 2023

Proceedings of the 19th International Flow Measurement Conference 2022 on Flow Measurement - FLOMEKO 2022

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A pilot study was conducted to compare the microflow rate from 2 to 200 g/h in the APMP TCI project (TCFF_01_TCI2019). A syringe pump (Chemyx Nexus 3000) and Coriolis flowmeter (Bronkhorst M12) were used as the transfer standards. The comparisons were coordinated in the KRISS institute, which was also responsible for the pilot study. The volumetric flow rate was measured using a syringe pump and the measured flow rates were 33, 100, 333, 500, and 1000 μL/min and the institutes that participated in the international comparison of micro-liquid volumetric flow rates were KRISS, NMC A*STAR, and CMS, all of which used water as the working fluid. To measure the mass flow rate, a Coriolis flow meter was used; the flow rates were 2, 6, 20, 60, and 200 g/h and the institutes that participated in this international comparison of micro-liquid mass flow rates were KRISS, NMC A*STAR, CMS, NMIJ, and NIMT. All of the participating institutes used water as the working fluid, except for the NMIJ, which used light oil. The En values for the syringe pumps and mass flow meters were calculated based on reference values and were less than 1 for all the flow rates determined by the participating institutes. Therefore, the international equivalence of the microliquid flow standard system of the participating APMP institutions was confirmed.

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Section: Introductionmentioning

confidence: 99%

Intercomparison of micro-liquid flow standard system in APMP

Lee¹,

Zeng²,

Tsai³

et al. 2023

Proceedings of the 19th International Flow Measurement Conference 2022 on Flow Measurement - FLOMEKO 2022

View full text Add to dashboard Cite

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“…The EMPIR Project -MeDD II, Metrology for Drug Delivery [1], funded under the EMPIR program of the European Commission, started in June 2018, with the evolvement of 16 partners including: nine National and Designated Metrology Institutes (IPQ -Portugal, CETIAT -France, CMI -Czech Republic, DTI -Denmark, METAS -Switzerland, NEL -United Kingdom, NQIS -Greece, RISE -Sweden and KRISS -Korea), four companies (DNV GL -The Netherlands, HSG-IMIT -Germany, INESC MN -Portugal, BHT -The Netherlands, and 3 universities, THL -Germany, UMC Utrecht-The Netherlands and the University of Strathclyde from Scotland and has the overall aim to improve dosing accuracy and enable traceable measurements of volume, flow and pressure of existing drug delivery devices and inline sensors operating at very low flow rates (lower than 100 nL/min). This can be achieved through the development of new calibration methods and improved metrological infrastructures.…”

Section: Introductionmentioning

confidence: 99%

Metrology for Drug Delivery project – results and impact

Batista¹,

Bissig²,

Morgan³

et al. 2023

Proceedings of the 19th International Flow Measurement Conference 2022 on Flow Measurement - FLOMEKO 2022

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This paper presents the major impacts of the work developed in EMPIR Project -MeDD II, Metrology for Drug Delivery in the reference standards used for flow rate determination of drug delivery devices and the results obtained in each work package, with a special focus on the primary standards developed by the partners using different technologies. These new primary standards were validated via an inter-laboratory comparison using two different type of flow meters and a precision syringe pump, in a range from 1500 nL/min down to 5 nL/min. This inter-comparison was performed between nine participating laboratories, each with different methodologies, measurement principles, flow ranges, operating conditions, and measurement uncertainty values.

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“…Therefore, a well-defined metrological infrastructure is needed to ensure that the precision and the accuracy of the pump flow rate error are within expected limits specified by the manufacturer or by the user of the pump, as the metrological infrastructure ensures a traceability to a commonly agreed standards as the SI units [4]. This paper describes part of the test program of the EMPIR project 18HLT08 MeDDII -Metrology for drug delivery [5] which has been conducted with the aim of getting knowledge about several selected medical flow devices in order to define the best calibration practices for them. Particularly, the tests of a syringe pump, an infusion device analyser (IDA) and an insulin pump are described.…”

Section: Introductionmentioning

confidence: 99%

Testing micro-flow devices for medical applications

Geršl¹,

Niemann²,

Bissig³

et al. 2023

Proceedings of the 19th International Flow Measurement Conference 2022 on Flow Measurement - FLOMEKO 2022

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Almost every medical department at hospitals all around the world uses infusion devices to administrate fluids, nutrition, and medications to patients for the treatment of numerous different diseases and ailments. Depending on the intended use of the equipment e.g., if it is used for anaesthesia of adults or for medical treatment of premature infants, the accuracy of the equipment can be more or less important. A well-defined metrological infrastructure can help to ensure that infusion devices function properly and are as accurate as needed for their use. However, to establish a metrological infrastructure an appropriated knowledge about infusion devices in use is necessary that enables calibration and testing procedures to be properly defined. This paper summarises the results of various tests conducted with three types of devicesa syringe pump, an infusion device analyser and an insulin pump.

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New EMPIR project – Metrology for Drug Delivery

Cited by 20 publications

References 9 publications

Intercomparison of micro-liquid flow standard system in APMP

Intercomparison of micro-liquid flow standard system in APMP

Metrology for Drug Delivery project – results and impact

Testing micro-flow devices for medical applications

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