Metrology for Drug Delivery project – results and impact

Abstract

This paper presents the major impacts of the work developed in EMPIR Project -MeDD II, Metrology for Drug Delivery in the reference standards used for flow rate determination of drug delivery devices and the results obtained in each work package, with a special focus on the primary standards developed by the partners using different technologies. These new primary standards were validated via an inter-laboratory comparison using two different type of flow meters and a precision syringe pump, in a range from 1500 nL/min down to 5 nL/min. This inter-comparison was performed between nine participating laboratories, each with different methodologies, measurement principles, flow ranges, operating conditions, and measurement uncertainty values.