New Diterpene and Indole Alkaloid Analogs from the Streptomyces malaysiensis SCSIO 41397

Abstract

One new cyclooctatin-type diterpenoid, 15-hydroxycyclooctatin (1), and one new indole alkaloid, streptoprenylindole D (3), along with 9 known compounds, were isolated from the Streptomyces malaysiensis SCSIO 41397. Their structures were established on the basis of spectroscopic analysis, optical rotation, and by a comparison with data from the literature. All isolated compounds were evaluated for their antibacterial (MRSA), antitumor (22Rv1 and PC-3) and antiviral (HSV-1/2) activities. According to the analysis of biological gene clusters in the whole genome, we preliminarily locate the gene clusters related to the synthesis of 15-hydroxycyclooctatin (1).

Marine natural products

“…zoanthids that the hydroid associates with. While not all compounds were tested, dentithecamide A was the most active (IC 50 12 mM) at suppressing PAX3-FOXO1-driven transcription, a driver of so tissue rhabdomyosarcoma in young people. While this level of activity is considered inactive by the criteria set for this review, the value is presented here to indicate that dentithecamide A is in fact an inhibitor, albeit weakly, of a transcription factor fusion which some view as undruggable.…”

“…46 Other Streptomyces -sourced alkaloids included the strepotindoles A – D 155 – 158 , 47 streptocarbazoles F–H 159 – 161 , 48 penzonemycins A 162 and B 163 and demethylmycemycin A 164 , 49 as well as an indole, streptoprenylindole D 165 , co-isolated with a diterpene, 15-hydroxycyclooctatin 166 . 50 Piercidins A5 167 and G1 168 were isolated from a sediment-derived Streptomyces sp. 51 and two pyrrolosesquiterpenes, glaciapyrroles D 169 and E 170 were reported from a deep-sea sediment-derived Streptomyces sp.…”