New diagnostic possibilities in systemic neonatal infections: metabolomics

Abstract

Systemic neonatal infection is a serious complication in preterm and term infants and is defined as a complex clinical syndrome caused by bacteria, fungi and virus. Sepsis remains among the leading causes of death in both developed and underdeveloped countries above all in the neonatal period. Earlier diagnosis may offer the ability to initiate treatment to prevent adverse outcomes. There have been many studies on various diagnostic haematological markers like acute phase reactants, C-reactive protein, procalcitonin, interleukins and presepsin. However, there is still no single test that satisfies the criteria as being the ideal marker for the early diagnosis of neonatal sepsis. In this regard, metabolomic analysis seems to be a promising method for determining metabolic variations correlated with systemic neonatal infections.

Neonatal infections due to multi-resistant strains: Epidemiology, current treatment, emerging therapeutic approaches and prevention

“…Metabolomics a method based on the study of the complete set of metabolites contained in a biological sample could be able to identify a small number of metabolites for identification of septic newborns [66,67].…”

Neonatal-sepsis causative microorganisms and antimicrobial sensitivity in NICU, Children Hospital and Institute of Child Health, Multan.

“…With advances in neonatal intensive care, increasingly immature, very low birth weight newborns are surviving, remaining in hospital for long periods of time where they were at risk for hospital acquired infection. [4][5][6] A wide variety of pathogens can affect the new born, including bacteria, viruses, fungi and protozoa. The purpose of study was to know the bacteriologic profile and recognition of the role and importance of antimicrobial stewardship in preventing infections and minimizing antimicrobial resistance.…”

“…the prevalence of organism in community, the place of birth and neonatal stay ( home or hospital), socio-economic status and ethnicity. 4 2 presence of indwelling catheters, ventricular shunts, endotracheal tubes, and alterations in the skin and mucus membrane barriers may favor infections. Previous used of antibiotics increases the likelihood of infections caused by more resistant bacteria and fungi.…”

“…Previous used of antibiotics increases the likelihood of infections caused by more resistant bacteria and fungi. 4,5 CRITERIA FOR THE DIAGNOSIS OF SEPSIS 6 (High sensitivity CRP, serum soluble intercellular adhesion molecule 1, soluble e-selectin and serum amyloid a individually or in combination will be the future specific markers for sepsis)…”

Metabolomics in the diagnosis of sepsis

“…Today, no single test satisfies the criteria as being the ideal marker for the early diagnosis of neonatal sepsis. Analysis of the entire metabolome is a promising method for determining metabolic variations correlated with sepsis [1-6]. …”