New Developments in Liposomal Drug Delivery

Pattni, Bhushan S.; Chupin, Vladimir; Torchilin, Vladimir P.

doi:10.1021/acs.chemrev.5b00046

Cited by 1,226 publications

(857 citation statements)

References 397 publications

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“…Primarily, liposomes have been studied as drug delivery agents [111][112][113][114]; nevertheless, increased attention has been brought to the development of multifunctional liposomes as theranostic agents. With this kind of platforms, diagnosis and treatment can be achieved simultaneously.…”

Section: Liposomesmentioning

confidence: 99%

Molecular Imaging with 68Ga Radio-Nanomaterials: Shedding Light on Nanoparticles

et al. 2018

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Abstract:The combination of radioisotopes and nanomaterials is creating a new library of tracers for molecular imaging, exploiting the sensitivity of nuclear imaging techniques and the size-dependent properties of nanomaterials. This new approach is expanding the range of applications, including the possibility of theranostics. Among the many different combinations, the use of 68 Ga as the radioisotope in the radio-nanomaterial is particularly convenient. The physicochemical properties of this isotope allow incorporating it into many materials with great chemical flexibility. Furthermore, its production from a benchtop generator eases the preparation of the tracer. Here, we review main results from the last years in which a nanomaterial has been radiolabeled with 68 Ga. In thus process, we pay attention to the use of nanomaterials for biomedical imaging in general and main properties of this radioisotope. We study the main methods to carry out such radiolabeling and the most important applications for molecular imaging.

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Section: Liposomesmentioning

confidence: 99%

Molecular Imaging with 68Ga Radio-Nanomaterials: Shedding Light on Nanoparticles

et al. 2018

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“…Advances in the designing of enzymosomes are variably applicable in fields like production of new recombinant proteins, biotechnological products etc. [29,30].…”

Section: Fig 1: Diagrammatic Representation Of Structure Of Lipoid Bmentioning

confidence: 99%

Enzymosomes: A Rising Effectual Tool for Targeted Drug Delivery System

et al. 2017

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The study aims to develop enzymosomes as an emerging novel drug delivery system for site-specific action. Enzymosomes utilises the specific nature of an enzyme, which is binding to a specific substrate at a controlled rate and catalysing product production step. An enzyme is encapsulated by coupling covalently to the surface of liposomes/lipid vesicles to form enzymosomes. Enzymes links through acylation, direct conjugation, physical adsorption, encapsulation methods to prepare enzymosomes with targeted action. Such novel drug delivery systems prove effective drug release and concomitantly reduces undesirable side effects of conventional treatment methods and hence showcase improvement in the long-term therapy of the disease. They are a promising substitute to conventional treatment therapies of gout, antiplatelet activities etc. Enzymosomes are newly designed supramolecular vesicular delivery systems to be useful as a tool in pharmaceutics for the raising of drug targeting and physicochemical properties and hence bioavailability. It shows beneficial effects of drugs with a narrow precision because targeting of these drugs to their site of action improves the drugs overall pharmacodynamics and pharmacokinetic profile. It also minimizes alterations in the normal enzymatic activity, thus enhancing half-life and achieve enzyme activity on targeted sites such as cancerous cells.

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“…Later, these closed bilayer structures were termed as liposomes by Sessa (Sessa and Weissmann 1968). The liposome comprises of an aqueous compartment surrounded by one, or more lipid bilayers (Gregoriadis and Florence 1993;Pattni et al 2015). Initially, liposomes were used to study the physical behavior of biological membranes like lipids orientation in bilayer, physiochemical characterization of lipids and ion transport across bio membranes (Bangham 1972;Gregoriadis and Florence 1993).…”

Section: Liposomesmentioning

confidence: 99%

“…Liposomes can be classified on the basis of size and the number of phospholipid membrane layers (Akbarzadeh et al 2013;Pattni et al 2015) as depicted in Figure 1.…”

Section: Types Of Liposomesmentioning

confidence: 99%

“…Nanocarriers have larger surface area as compared to bigger particles, which can be easily modified to encapsulate large amount of drug, to increase the blood circulation time and to enhance the accumulation of drugs in solid tumors via the enhanced permeability and retention (EPR) effect as well as selective targeting of tumor cells Allen and Cullis 2013;Bozzuto and Molinari 2015). Nanocarriers also improve the solubility, bioavailability and pharmacokinetics properties of chemotherapeutics (Gregoriadis and Florence 1993;Bozzuto and Molinari 2015;Pattni et al 2015). Currently, a variety of nanocarriers such as liposomes, polymeric nanoparticles, micelles, nanotubes, etc are already in the market, or under research and evaluation for cancer treatment (Sutradhar and Lutful 2014).…”

Section: Introductionmentioning

confidence: 99%

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