New developments in giant cell arteritis

Frohman, Larry; Wong, Aaron; Matheos, Kaliopy; Leon-Alvarado, Luis G.; Danesh‐Meyer, Helen V.

doi:10.1016/j.survophthal.2016.01.001

Cited by 25 publications

(29 citation statements)

References 151 publications

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“…The pathological examination indicated that these cells often exhibit atypical mitosis (Machado et al, 2016). Patients with advanced cancer often exhibited severe systemic symptoms and high recurrence rate after surgical excision, causing a big challenge for cancer therapy (Bax et al, 2016;Bendella et al, 2016;Frohman et al, 2016). In view of the enormous harm caused by cancer, the development of new antitumor treatments has become a research hotspot.…”

Section: Introductionmentioning

confidence: 99%

The Anticancer Properties of Tanshinones and the Pharmacological Effects of Their Active Ingredients

Han

Zhou

et al. 2020

Front. Pharmacol.

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Cancer is a common malignant disease worldwide with an increasing mortality in recent years. Salvia miltiorrhiza, a well-known traditional Chinese medicine, has been used for the treatment of cardiovascular and cerebrovascular diseases for thousands of years. The liposoluble tanshinones in S. miltiorrhiza are important bioactive components and mainly include tanshinone IIA, dihydrodanshinone, tanshinone I, and cryptotanshinone. Previous studies showed that these four tanshinones exhibited distinct inhibitory effects on tumor cells through different molecular mechanisms in vitro and in vivo. The mechanisms mainly include the inhibition of tumor cell growth, metastasis, invasion, and angiogenesis, apoptosis induction, cell autophagy, and antitumor immunity, and so on. In this review, we describe the latest progress on the antitumor functions and mechanisms of these four tanshinones to provide a deeper understanding of the efficacy. In addition, the important role of tumor immunology is also reviewed.

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Section: Introductionmentioning

confidence: 99%

The Anticancer Properties of Tanshinones and the Pharmacological Effects of Their Active Ingredients

Han

Zhou

et al. 2020

Front. Pharmacol.

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“…High sensitivity and specificity can be obtained by an experienced operator, but heterogeneous results have been reported in various studies of this technique, with sensitivities ranging from 35% to 86% [54,55]. Further, the optimal timing of CDUS for GCA diagnosis is unclear, with conflicting reports on the disappearance of the halo sign after commencement of therapy ranging from 2 days to 2 months [56]. Nevertheless, many studies and three meta-analyses [54,55,57] support a role for detection of the halo sign by CDUS in the diagnosis of GCA, and diagnostic utility may be improved by the inclusion of other abnormalities such as stenosis and occlusion [57].…”

Section: Modalitymentioning

confidence: 99%

Giant cell arteritis

Ninan

Lester

Hill

2016

Best Practice & Research Clinical Rheumatology

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“…Ряд морфологических исследований выявили в биоптатах височных артерий парвовирус В19, вирус герпеса 3-го типа, Mycoplasma pneumoniae, Chlamydia pneumonia [3][4][5][6]. Однако другие исследования не подтвердили связь вышеперечисленных инфекций с гигантоклеточным артериитом [7,8].…”

Section: Introductionunclassified

Giant Cell Arteritis in Ophthalmology Practice: a Case Report

Чернуха¹,

Атарщиков

Хамнагдаева

et al. 2019

Oftalʹmologiâ

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Introduction. Giant cell (temporal) arteritis refers to a group of chronic and acute systemic vasculitis mainly affecting the extracranial and intracranial arteries of large and medium caliber. Loss of vision due to anterior ischemic optic neuropathy (AION) or occlusion of the central retinal artery is one of the most severe and most common complications of giant cell arteritis. This case report describes a patient with giant cell arteritis, the outcome of it was a total vision loss in the right eye. The patient repeatedly visited the ophthalmologists in the outpatient clinics with complaints of intermittent episodes of vision loss.Purpose. To present methods of diagnosis and treatment, through which the doctor at the initial reception will be able to suspect the disease and start treatment timely.Conclusions. The anamnestic criteria for the GCA diagnosis in the practice of ophthalmologist are: female, age over 50 years, headaches with paresthesia, intermittent lameness of the mandible, short-term episodes of vision loss. The necessary laboratory methods of research include: clinical blood test with determination of erythrocyte sedimentation rate, determination of C-reactive protein level.

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New developments in giant cell arteritis

Cited by 25 publications

References 151 publications

The Anticancer Properties of Tanshinones and the Pharmacological Effects of Their Active Ingredients

The Anticancer Properties of Tanshinones and the Pharmacological Effects of Their Active Ingredients

Giant cell arteritis

Giant Cell Arteritis in Ophthalmology Practice: a Case Report

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