The Anticancer Properties of Tanshinones and the Pharmacological Effects of Their Active Ingredients

Fu, Li; Han, Bing; Zhou, Yang; Ren, Jie; Cao, Wenzhi; Patel, Gopal; Kai, Guoyin; Zhang, Jun

doi:10.3389/fphar.2020.00193

Cited by 59 publications

(88 citation statements)

References 165 publications

(105 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present study mainly investigated the effects of Tanshinone I (a diterpenoid quinones compound) and salvianolate (a water-soluble compound) on lung adenocarcinoma. Tanshinone I is a notable component of the fat-soluble compounds that can be isolated from Salvia miltiorrhiza (28). In the present study, hub genes and key pathways involved in lung adenocarcinoma following administration of different dosages of Tanshinone I were identified.…”

Section: Discussionmentioning

confidence: 79%

Effects of Salvia miltiorrhiza extract on lung adenocarcinoma

Tian

Mei

et al. 2021

Exp Ther Med

View full text Add to dashboard Cite

Lung adenocarcinoma is the most common subtype of non-small cell lung carcinoma. Tanshinone I is an important fat-soluble component in the extract of Salvia miltiorrhiza that has been reported to inhibit lung adenocarcinoma cell proliferation. However, no studies have clearly demonstrated changes in lung adenocarcinoma gene expression and signaling pathway enrichment following Tanshinone I treatment. And it remains unclear whether salvianolate has an effect on lung adenocarcinoma. The present study downloaded the GSE9315 dataset from the Gene Expression Omnibus database to identify differentially expressed genes (DEGs) and the underlying signaling pathways involved after Tanshinone I administration in the lung adenocarcinoma cell line CL1-5. The results revealed that there were 28 and 102 DEGs in the low dosage group (0.01 and 0.10 µg/ml Tanshinone I) and medium dosage groups (1 and 10 µg/ml Tanshinone I), respectively. In the low dosage group, DEGs were mainly enriched in 'positive regulation of T-helper cell differentiation' and 'protein complex'. In the medium dosage group, 102 DEGs were enriched in 'MAPK cascade' and 'extracellular exosome'. Kyoto Encyclopedia of Genes and Genomes pathway analysis demonstrated enrichment of both groups in the PI3K-Akt signaling pathway. Furthermore, there were nine overlapping DEGs [ADP ribosylation factor-interacting protein 2, chemokine (C-X-C motif) ligand 6, SH2 domain-containing adaptor protein B, Src homology 2 domain-containing transforming protein1, collagen type VI α1 chain, elastin, integrin subunit α, endoplasmic reticulum mannosyl-oligosaccharide 1,2-α-mannosidase and sterile α motif domain-containing 9 like] between the two groups, which serve to be potential targets for the treatment of lung adenocarcinoma. The present study also investigated the possible effects of salvianolate on lung adenocarcinoma in vivo using nude mouse xenograft models injected with the A549 cell line. The data revealed that salvianolate not only suppressed lung adenocarcinoma tumor growth of in nude mice, but also downregulated the expression levels of ATP7A and ATP7B, which are important proteins in the tumorigenesis and chemotherapy of lung adenocarcinoma. The present study provided evidence for the potential use of Salvia miltiorrhiza extract for treating lung adenocarcinomas in the clinic.

show abstract

Section: Discussionmentioning

confidence: 79%

Effects of Salvia miltiorrhiza extract on lung adenocarcinoma

Tian

Mei

et al. 2021

Exp Ther Med

View full text Add to dashboard Cite

show abstract

“…Natural products are a good source of antitumor compounds. In recent years, auraptene have drawn scientists’ attention because of its broad-spectrum and effective antitumor activities ( Fu et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

A Review of Auraptene as an Anticancer Agent

2021

View full text Add to dashboard Cite

Auraptene is a bioactive monoterpene coumarin isolated from Citrus aurantium and Aegle marmelos that belong to the Rutaceae family. Auraptene can modulate intracellular signaling pathways that control cell growth, inflammation and apoptosis and can exert pharmacological properties such as anti-bacterial, anti-fungal, antileishmania and anti-oxidant activity. Auraptene had inhibitory and chemo-preventive effects on the proliferation, tumorigenesis and growth of several cancer cell lines through increase in the activity of glutathione S-transferase, formation of DNA adducts and reduction of the number of aberrant crypt foci. Auraptene exhibits anticancer effects via targeting different cell signaling pathways such as cytokines, genes modulating cellular proliferation, growth factors, transcription factors and apoptosis. The present review is a detailed survey of scientific researches on the cytotoxicity and anticancer activity of Auraptene on cancer cells and tumor bearing animals.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Danshen (Salvia miltiorrhiza), an important traditional Chinese herb, has been used extensively as a healthy food and in clinical usage for more than 1000 years [11][12][13]. Modern advanced technological analysis has clarified that the major constituents of danshen are hydrophilic phenolic acids and lipophilic compounds [11][12][13]. Studies have shown that both these constituents contribute to most of the bioactivities and therapeutic capabilities of danshen, including antioxidation [13], anti-inflammation [14], and mitigation of cardiovascular diseases [15].…”

Section: Introductionmentioning

confidence: 99%

Dihydroisotanshinone I as a Treatment Option for Head and Neck Squamous Cell Carcinomas

Hsu

Yang

Tsai

et al. 2021

IJMS

View full text Add to dashboard Cite

Head and neck squamous cell carcinomas (HNSCCs) are the most common cancers of the head and neck, and their prevalence is rapidly increasing. HNSCCs present a clinical challenge because of their high recurrence rate, therapeutic resistance to radiation and chemotherapy drugs, and adverse effects. Hence, traditional Chinese herbal treatment may be advantageous to therapeutic strategies for HNSCCs. Danshen (Salvia miltiorrhiza), a well-known Chinese herb, has been extensively applied in treatments for various diseases, including cancer, because of its high degree of safety and low rate of adverse effects despite its unclear mechanism. Thus, we aimed to explore the possible anticancer effects and mechanisms of dihydroisotanshinone I (DT), a compound in danshen (extract from danshen), on HNSCCs. Three HNSCCs cell lines were used for in vitro studies, and a Detroit 562 xenograft mouse model was chosen for in vivo studies. Our in vitro results showed that DT could initiate apoptosis, resulting in cell death, and the p38 signaling partially regulated DT-initiated cell apoptosis in the Detroit 562 model. In the xenograft mouse model, DT reduced tumor size with no obvious adverse effect of hepatotoxicity. The present study suggests that DT is a promising novel candidate for anti-HNSCCs therapy.

show abstract

The Anticancer Properties of Tanshinones and the Pharmacological Effects of Their Active Ingredients

Cited by 59 publications

References 165 publications

Effects of Salvia miltiorrhiza extract on lung adenocarcinoma

Effects of Salvia miltiorrhiza extract on lung adenocarcinoma

A Review of Auraptene as an Anticancer Agent

Dihydroisotanshinone I as a Treatment Option for Head and Neck Squamous Cell Carcinomas

Contact Info

Product

Resources

About