New Developed and Validated Spectroscopic Method for the Simultaneous Estimation of Terbinafine Hydrochloride and Fluconazole

Thakur, Bhumika; Kumar, Inder

doi:10.22159/ijpps.2020v12i11.39344

Cited by 5 publications

(7 citation statements)

References 18 publications

(13 reference statements)

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“…Drug content was examined in the samples using a UV-visible spectrophotometer at 262 nm. [47][48] [49] The slope has been found from y= 0.0271x where the value of the regression coefficient (R 2 ) was found to be 0.9988.…”

Section: Optimization Of the Formulationmentioning

confidence: 99%

Optimization and evaluation of itraconazole-loaded nanostructured lipid carriers incorporated gel for topical drug delivery

ROY BISWAS,

PAUL,

DUTTA

et al. 2024

jrp

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Nanotechnology is a relatively new technology that creates a lot of possibilities for smart drug manufacturing and delivery techniques. Nanostructured lipid carrier (NLC) is a significant advantage over the other drug delivery system. NLC-employed gel (Nanogel), which is composed of hydrophilic polymer network-based nanoparticles, ranges from 10 nm to 1000 nm. Because of its great loading capacity, high stability, extended contact period, and thus extended therapeutic impact, nanogel has been used in topical administration. In this work, Itraconazole has been chosen as an API. With the use of Central Composite Design, NLC has been prepared with two variables. They are combined with solid lipid and liquid lipid, and with the aid of a surfactant and are stabilized in aqueous dispersion. The Hot homogenization technique was adopted for the preparation of the same. The mixture was homogenized for 20 minutes at a speed of 2000-8000 RPM which was afterwards sonicated . The formed NLCs were incorporated into hydrogel using Carbopol 934 P as a gel-forming agent. Particle size was measured with the help of the Dynamic light scattering (DLS) method. The results revealed that the particles' were in nano range (54nm -488nm). Out of 39 optimized combination found through Design of Expert software, the matched prepared formulation (NF 3) was subjected to in vitro drug diffusion study, it was found that drug diffusion from that formulation steadily increased and remained constant after 5 hours. Drug diffusion was almost 89.15% in 7 hours. Following an ex vivo permeation investigation on goat skin of the same , it was seen that the permeation of Itraconazole through goat abdominal skin from the optimized product was around 51.67% in 7 hours.

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Section: Optimization Of the Formulationmentioning

confidence: 99%

Optimization and evaluation of itraconazole-loaded nanostructured lipid carriers incorporated gel for topical drug delivery

ROY BISWAS,

PAUL,

DUTTA

et al. 2024

jrp

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“…A certain Conc. of each drug was taken and scans the spectra in the range of 200-400 under the UV-Vis spectrophotometer and observes the overlay spectra of both drugs for Isoabsorptive Point [7].…”

Section: Determination Of Isoabsorptive Pointmentioning

confidence: 99%

“…Where N is the standard deviation of the intercepts of the drug and S is the slope of the corresponding calibration curve [7,1].…”

Section: Limit Of Detection and Limit Of Quantificationmentioning

confidence: 99%

Development and Validation of UV-Spectroscopic Method for Simultaneous Estimation of Metformin Hydrochloride and Pravastatin Sodium

SHARMA

Verma

Kumar

et al. 2023

J. Pharm. Res. Int.

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Introduction: A new, simple, precise, accurate, and reproducible method was developed and validated for the simultaneous estimation of Metformin Hydrochloride (MH) and Pravastatin Sodium (PS) in pure form. Methodology: Simultaneous estimation of Metformin Hydrochloride (MH) and Pravastatin Sodium (PS) was estimated by ultraviolet (UV) spectrophotometry using the absorbance subtraction method. The method was based on the measurement of absorbance at two wavelengths 232 nm and 238 nm, of metformin and Pravastatin Sodium respectively. These studies were performed at three different levels (75%, 100%, and 125%) and the % recovery of MH and PS was calculated. Results: The LOD and LOQ were found to be 0.481 μg/ml and 0.670μg/ml for MH and 1.15μg/ml and 1.68μg/ml for PS respectively. All the statically analyses were within the standard limits. It proves that the method was repeatable and selective for the simultaneous. Conclusion: Therefore, the present study concludes that it can be successfully used for simultaneous estimation of MH and PS in pure and pharmaceutical dosage forms. The developed method was found to be simple, precise, and accurate.

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“…The absorbance values for resultant solutions were taken at wavelength of respective solvents as blank by UV-visible spectrophotometer. In the end calibration curve was created (8).…”

Section: Drug Solubilitymentioning

confidence: 99%

Solubility Optimization of Terbinafine Hydrochloride Solid Dispersion by Binary and Ternary Method

Masood,

Mansoor,

Pervaiz

et al. 2023

IJPIHS

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Background: In the process of drug development, the most challenging factor is poor solubility. To formulate an oral dosage form, poor solubility and bioavailability are the main challenges. Objective: The objective of this research was to increase the solubility of terbinafine hydrochloride (TBF) by formulating binary and ternary solid dispersion (SD) by different techniques. Terbinafine hydrochloride is a BCS class II drug having low solubility, poor absorption and low bioavailability. Methodology: Physical mixture (PMSD), solvent evaporation (SESD), and kneading method (KMSD) were used to improve the solubility of TBF and prepare PMSD, SESD, KMSD and ternary solid dispersion (TSD) using PVPK30 and sodium lauryl sulphate (SLS) as hydrophilic polymer and surfactant. Nine formulations were designed to formulate binary SD by varying the ratios of TBF, PVPK30 and SLS (1:1, 1:3 and 1:5). Three formulations were prepared to form TSD with varying percentage of TBF with best formulation from binary SD (5%, 10% and 15%). Entire formulations were test for solubility studies, and a formulation that exhibit maximum increased solubility was selected to prepare binary and ternary SD of TBF. Every developed formulation was characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and scanning electron microscopy (SEM) to observe chemical interactions, crystallinity and morphological changes, respectively. Results: The results show that binary SD and TSD has increased solubility in comparison with a pure drug. Although, TSD prepared using kneading method displayed the highest drug solubility (14.48 times) as compared to pure drug. Conclusion: The research determined that the solubility of TBF increased due to increased wettability, hydrophilicity of the carrier and reduced crystallinity.

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New Developed and Validated Spectroscopic Method for the Simultaneous Estimation of Terbinafine Hydrochloride and Fluconazole

Cited by 5 publications

References 18 publications

Optimization and evaluation of itraconazole-loaded nanostructured lipid carriers incorporated gel for topical drug delivery

Optimization and evaluation of itraconazole-loaded nanostructured lipid carriers incorporated gel for topical drug delivery

Development and Validation of UV-Spectroscopic Method for Simultaneous Estimation of Metformin Hydrochloride and Pravastatin Sodium

Solubility Optimization of Terbinafine Hydrochloride Solid Dispersion by Binary and Ternary Method

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