New cyclopiane diterpenes with anti-inflammatory activity from the sea sediment-derived fungus Penicillium sp. TJ403-2

Li, Fengli; Sun, Wenping; Zhang, Sitian; Gao, Weixi; Lin, Shuang; Yang, Beiye; Chai, Chenwei; Li, Huaqiang; Wang, Jianping; Hu, Zhengxi; Zhang, Yonghui

doi:10.1016/j.cclet.2019.04.036

Cited by 24 publications

(15 citation statements)

References 20 publications

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“…, it was confirmed that the five compounds were artanomaloide (66), 8-acetylarteminolide(67), arteminone(68 and 69), and dehydromatricarin(70). All the five belong to sesquiterpene lactone.…”

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confidence: 80%

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An overview on natural farnesyltransferase inhibitors for efficient cancer therapy

Dai

Sun

Zhang

et al. 2020

Journal of Enzyme Inhibition and Medicinal Chemistry

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As one of the world's five terminally ills, tumours can cause important genetic dysfunction. However, some current medicines for tumours usually have strong toxic side effects and are prone to drug resistance. Studies have found that farnesyltransferase inhibitors (FTIs) extracted from natural materials have a good inhibiting ability on tumours with fewer side effects. This article describes several FTIs extracted from natural materials and clarifies the current research progress, which provides a new choice for the treatment of tumours.

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confidence: 80%

“…belongs to Trichocomaceae and grows on decaying fruits, vegetables, meat, and various moist organic substances. Its metabolites show excellent antibacterial and anti-inflammatory activities, moreover, good killing effect on larvae such as Culex quinquefasciatus 69,70 .…”

Section: Penicillium Spmentioning

confidence: 99%

An overview on natural farnesyltransferase inhibitors for efficient cancer therapy

Dai

Sun

Zhang

et al. 2020

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…An investigation of the extracts from Penicillium sp. TJ403-2, a sea sediment-derived fungus, yielded three new rare diterpenes identified as 13β-hydroxy conidiogenone C (243), 12β-hydroxy conidiogenone C (244), and 12β-hydroxy conidiogenone D (245) [67]. Regarding anti-inflammatory activity against LPS-induced NO production in RAW 264.7 cells, 243 displayed notable inhibitory potency, with an IC 50 value of 2.19 µM-three-fold lower than the p.c.…”

Section: Diterpenesmentioning

confidence: 99%

“…Regarding anti-inflammatory activity against LPS-induced NO production in RAW 264.7 cells, 243 displayed notable inhibitory potency, with an IC 50 value of 2.19 µM-three-fold lower than the p.c. indomethacin (IC 50 = 8.76 µM) [67]. Moreover, further experiments showed that 243 could significantly inhibit the production of cell cytokines (IL-1β, IL-13, TNF-α, GM-CSF, MIP-1β, and MCP-1), suppress inducible nitric oxide synthesis (iNOS) and cyclooxygenase-2 (COX-2) protein expression in a dose-dependent manner, and abolish the nuclear translocation of NF-kB p65 in LPS-activated RAW264.7 cells [67].…”

Section: Diterpenesmentioning

confidence: 99%

A Review of Terpenes from Marine-Derived Fungi: 2015–2019

Jiang

Guo

et al. 2020

Marine Drugs

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Marine-derived fungi are a significant source of pharmacologically active metabolites with interesting structural properties, especially terpenoids with biological and chemical diversity. In the past five years, there has been a tremendous increase in the rate of new terpenoids from marine-derived fungi being discovered. In this updated review, we examine the chemical structures and bioactive properties of new terpenes from marine-derived fungi, and the biodiversity of these fungi from 2015 to 2019. A total of 140 research papers describing 471 new terpenoids of six groups (monoterpenes, sesquiterpenes, diterpenes, sesterterpenes, triterpenes, and meroterpenes) from 133 marine fungal strains belonging to 34 genera were included. Among them, sesquiterpenes, meroterpenes, and diterpenes comprise the largest proportions of terpenes, and the fungi genera of Penicillium, Aspergillus, and Trichoderma are the dominant producers of terpenoids. The majority of the marine-derived fungi are isolated from live marine matter: marine animals and aquatic plants (including mangrove plants and algae). Moreover, many terpenoids display various bioactivities, including cytotoxicity, antibacterial activity, lethal toxicity, anti-inflammatory activity, enzyme inhibitor activity, etc. In our opinion, the chemical diversity and biological activities of these novel terpenoids will provide medical and chemical researchers with a plenty variety of promising lead compounds for the development of marine drugs.

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“…Marine microorganisms have been evidenced as prolific sources of structurally intriguing secondary metabolites with pharmaceutical potential [1,2] . Among them, the fungus come to be the most important producer [3,4] . As a matter of fact, fungal marine natural products (MNPs) reported in 2019 represent almost half of the total new MNPs [5] …”

Section: Introductionmentioning

confidence: 99%

Chemical Constituents of the Marine Fungus Penicillium sp. MCCC 3A00228

Wang

Huang

Xiao

et al. 2021

Chemistry & Biodiversity

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One new (d‐arabinitol‐anofinicate, 1) and fourteen known (2–15) compounds were isolated from the marine Penicillium sp. MCCC 3A00228. The structure of the new compound was established mainly by extensive spectroscopic analyses. Compound 1 exhibited weak transcriptional effect on Nur77. While compound 13 showed moderate in vitro anti‐proliferative effect against QGY7701, H1299, and HCT116 tumor cells with IC50 values of 21.2 μM, 18.2 μM, and 17.6 μM, respectively.

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New cyclopiane diterpenes with anti-inflammatory activity from the sea sediment-derived fungus Penicillium sp. TJ403-2

Cited by 24 publications

References 20 publications

An overview on natural farnesyltransferase inhibitors for efficient cancer therapy

An overview on natural farnesyltransferase inhibitors for efficient cancer therapy

A Review of Terpenes from Marine-Derived Fungi: 2015–2019

Chemical Constituents of the Marine Fungus Penicillium sp. MCCC 3A00228

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