New Cu(II), Pd(II), and Au(III) Complexes with 2-Thiouracil: Synthesis, Characteration, and Antibacterial Studies

Marinova, Petja; Tsoneva, S.; Frenkeva, M.; Blazheva, Denica; Slavchev, Aleksandar; Penchev, P.

doi:10.1134/s1070363222080278

Cited by 5 publications

(11 citation statements)

References 25 publications

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“…The highest activity against Gram-negative bacteria representatives was noted with the Cu(II) complex when tested against S. enterica. [26]. The free ligand 2-thiouracil did not hinder the growth and proliferation of P. vulgaris, but its Cu(II) and Au(III) complexes displayed mild to moderate activity.…”

Section: Biological Activities Antibacterial Activitymentioning

confidence: 92%

“…Recently, we have reported on Cu((II), Pd(II) and Au(III) complexes with 2-thiouracil [26]. The structures of the new compounds have been reviewed with UV-Vis, IR, 1 H, 13 C NMR and Raman spectral data.…”

Section: Synthesis Of Metal Complexes With 2-thiouracil and Its Deriv...mentioning

confidence: 99%

“…Among these bacteria, S. aureus exhibited the greatest susceptibility, particularly in response to the influence of the Cu(II) complex. [26]. Both yeast strains were impacted by the unbound ligand and its complexes.…”

Section: Biological Activities Antibacterial Activitymentioning

confidence: 99%

“…The most potent antifungal activity was observed with the Cu(II) complex against S. cerevisiae. [26].…”

Section: Biological Activities Antibacterial Activitymentioning

confidence: 99%

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Synthesis and Biological Activities of Some Metal Complexes of 2-Thiouracil and Its Derivatives: A Review

Marinova,

Tamahkyarova

2023

Preprint

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The thionamide antithyroid drugs were discovered largely following serendipitous observations by numerous researchers in the 1940s who found that sulfhydryl-containing compounds were goitrogenic in animals. Prof. Edwin B. Astwood was the first to use these compounds to treat hyperthyroidism. In this review, we summarize the history of the development of these drugs and the coordination possibility of 2-thiouracil and its derivatives, as well as the biological activities of some of its complexes. Some of them are used as agents for the treatment of tuberculosis, and arthritis, others have bactericidal and fungicidal activity, the third cytotoxic properties, and could be used to treat various types of cancer.

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Section: Biological Activities Antibacterial Activitymentioning

confidence: 92%

Section: Synthesis Of Metal Complexes With 2-thiouracil and Its Deriv...mentioning

confidence: 99%

Section: Biological Activities Antibacterial Activitymentioning

confidence: 99%

“…The most potent antifungal activity was observed with the Cu(II) complex against S. cerevisiae. [26].…”

Section: Biological Activities Antibacterial Activitymentioning

confidence: 99%

See 2 more Smart Citations

Synthesis and Biological Activities of Some Metal Complexes of 2-Thiouracil and Its Derivatives: A Review

Marinova,

Tamahkyarova

2023

Preprint

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“…Recently, we have reported on Cu((II), Pd(II), and Au(III) complexes with 2-thiouracil [31]. The compound structure has been analyzed with UV-Vis, IR, 1 H, 13 C NMR, and Raman spectral data.…”

Section: Synthesis Of Metal Complexes With 2-thiouracil and Its Deriv...mentioning

confidence: 99%

Synthesis and Biological Activities of Some Metal Complexes of 2-Thiouracil and Its Derivatives: A Review

Marinova,

Tamahkyarova

2024

Compounds

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The thionamide antithyroid agents were discovered largely through observations carried out by various researchers in the 1940s that found that sulfhydryl-containing substances were goitrogenic in animals. Prof. Edwin B. Astwood started using these drugs to treat hyperthyroidism. In the current paper, we summarize the development background of these agents and the coordination possibility of 2-thiouracil and its derivatives, as well as the biological activities of some of its complexes. Some of them are used as agents for the treatment of tuberculosis, and arthritis, others have bactericidal and fungicidal activity, the third cytotoxic properties, and could be used to treat various types of cancer.

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Synthesis, Characterization, and Antibacterial Studies of New Cu(II) and Pd(II) Complexes with 6-Methyl-2-Thiouracil and 6-Propyl-2-Thiouracil

Marinova,

Hristov,

Tsoneva

et al. 2023

Applied Sciences

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The aim of the present study is to synthesize new metal complexes of 6-methyl-2-thiouracil and 6-propyl-2-thiouracil, elucidate their structures, and investigate their biological properties. All metal complexes were obtained after mixing water solutions of the corresponding metal salts and the ligand dissolved in DMSO and water solutions of NaOH in a metal-to-ligand ratio of 1:4:2. The structures of the new compounds are discussed based on melting point analysis (MP-AES) for Cu and Pd, UV-Vis, IR, ATR, 1H NMR, 13C NMR, and Raman spectroscopy. The interpretation of complex spectra is assisted by the data for 6-methyl-2-thiouracil and 6-propyl-2-thiouracil obtained from 1H-1H COSY, DEPT-135, HMBC and HMQC spectra. In addition, the antimicrobial activity of these complexes and the free ligands are assessed against both Gram-positive and Gram-negative bacteria, as well as yeasts. In general, the addition of metal ions improved the antimicrobial activity of both 6-methyl-2-thiouracil and 6-propyl-2-thiouracil. The Cu(II) complex with 6-methyl-2-thiouracil and the Pd(II) complex with 6-propyl-2-thiouracil exhibited the highest activity against the test microorganisms.

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New Cu(II), Pd(II), and Au(III) Complexes with 2-Thiouracil: Synthesis, Characteration, and Antibacterial Studies

Cited by 5 publications

References 25 publications

Synthesis and Biological Activities of Some Metal Complexes of 2-Thiouracil and Its Derivatives: A Review

Synthesis and Biological Activities of Some Metal Complexes of 2-Thiouracil and Its Derivatives: A Review

Synthesis and Biological Activities of Some Metal Complexes of 2-Thiouracil and Its Derivatives: A Review

Synthesis, Characterization, and Antibacterial Studies of New Cu(II) and Pd(II) Complexes with 6-Methyl-2-Thiouracil and 6-Propyl-2-Thiouracil

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