Synthesis, Characterization, and Antibacterial Studies of New Cu(II) and Pd(II) Complexes with 6-Methyl-2-Thiouracil and 6-Propyl-2-Thiouracil

Marinova, Petya; Hristov, Mariyan; Tsoneva, Slava; Burdzhiev, Nikola; Blazheva, Denica; Slavchev, Aleksandar; Varbanova, Evelina; Penchev, Plamen

doi:10.3390/app132413150

Cited by 4 publications

(15 citation statements)

References 42 publications

(98 reference statements)

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“…The highest antimicrobial activity was exhibited by the Cu(II) complex with 6-methyl-2thiouracil [27]. It was active against all of the test microorganisms.…”

Section: Biological Activities Antibacterial Activitymentioning

confidence: 99%

“…New complexes of Cu(II) and Pd(II) with 6-methyl-2-thiouracil and 6-propyl-2-thiouracil have been obtained [27]. All metal complexes have been obtained after mixing water solutions of the corresponding metal salts and the ligand dissolved in DMSO and water solutions of NaOH, in metalto-ligand ratio 1:4:2.…”

Section: Synthesis Of Metal Complexes With 2-thiouracil and Its Deriv...mentioning

confidence: 99%

“…The structures of the new compounds are reviewed based on melting point analysis, MP-AES for Cu and Pd, UV-Vis, IR, ATR, 1 H NMR, 13 C NMR and Raman spectroscopy. The interpretation of complex spectra is assisted by the data for 6-methyl-2-thiouracil and 6-propyl-2thiouracil obtained from 1 H-1 H COSY, DEPT-135, HMBC and HMQC spectra [27]. We have suggested, in Cu(II)L1 complex, probably the ligand could coordinate in a monodentate way through S2 and/or O4 atoms.…”

Section: Synthesis Of Metal Complexes With 2-thiouracil and Its Deriv...mentioning

confidence: 99%

“…Conversely, the addition of Pd(II) resulted in a loss of activity against E. faecalis and reduced activity against L. monocytogenes and C. albicans. [27].…”

Section: Biological Activities Antibacterial Activitymentioning

confidence: 99%

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Synthesis and Biological Activities of Some Metal Complexes of 2-Thiouracil and Its Derivatives: A Review

Marinova,

Tamahkyarova

2023

Preprint

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The thionamide antithyroid drugs were discovered largely following serendipitous observations by numerous researchers in the 1940s who found that sulfhydryl-containing compounds were goitrogenic in animals. Prof. Edwin B. Astwood was the first to use these compounds to treat hyperthyroidism. In this review, we summarize the history of the development of these drugs and the coordination possibility of 2-thiouracil and its derivatives, as well as the biological activities of some of its complexes. Some of them are used as agents for the treatment of tuberculosis, and arthritis, others have bactericidal and fungicidal activity, the third cytotoxic properties, and could be used to treat various types of cancer.

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“…The highest antimicrobial activity was exhibited by the Cu(II) complex with 6-methyl-2thiouracil [27]. It was active against all of the test microorganisms.…”

Section: Biological Activities Antibacterial Activitymentioning

confidence: 99%

Section: Synthesis Of Metal Complexes With 2-thiouracil and Its Deriv...mentioning

confidence: 99%

Section: Synthesis Of Metal Complexes With 2-thiouracil and Its Deriv...mentioning

confidence: 99%

“…Conversely, the addition of Pd(II) resulted in a loss of activity against E. faecalis and reduced activity against L. monocytogenes and C. albicans. [27].…”

Section: Biological Activities Antibacterial Activitymentioning

confidence: 99%

See 2 more Smart Citations

Synthesis and Biological Activities of Some Metal Complexes of 2-Thiouracil and Its Derivatives: A Review

Marinova,

Tamahkyarova

2023

Preprint

View full text Add to dashboard Cite

show abstract

“…The compound structure has been reviewed based on melting point analysis, MP-AES for Cu and Pd, UV-Vis, IR, ATR, 1 H NMR, 13 C NMR, and Raman spectroscopy. The interpretation of complex spectra is assisted by the data for 6-methyl-2-thiouracil and 6-propyl-2-thiouracil obtained from 1 H-1 H COSY, DEPT-135, HMBC, and HMQC spectra [32]. We have suggested that in the Cu(II)L1 complex, the ligand could probably coordinate in a monodentate way through S2 and/or O4 atoms.…”

Section: Synthesis Of Metal Complexes With 2-thiouracil and Its Deriv...mentioning

confidence: 99%

Synthesis and Biological Activities of Some Metal Complexes of 2-Thiouracil and Its Derivatives: A Review

Marinova,

Tamahkyarova

2024

Compounds

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The thionamide antithyroid agents were discovered largely through observations carried out by various researchers in the 1940s that found that sulfhydryl-containing substances were goitrogenic in animals. Prof. Edwin B. Astwood started using these drugs to treat hyperthyroidism. In the current paper, we summarize the development background of these agents and the coordination possibility of 2-thiouracil and its derivatives, as well as the biological activities of some of its complexes. Some of them are used as agents for the treatment of tuberculosis, and arthritis, others have bactericidal and fungicidal activity, the third cytotoxic properties, and could be used to treat various types of cancer.

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Enhancing Security Mechanisms for IoT-Fog Networks

Mansour,

Sakhi,

Kzaz

et al. 2024

Journal of Robotics and Control

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This study contributes to improving Morocco's fish canning industry by integrating artificial intelligence (AI). The primary objective involves developing an AI and image processing-based system to monitor and guarantee canning process quality in the facility. It commenced with an IoT-enabled device capable of capturing and processing images, leading to the creation of an AI-driven system adept at accurately categorizing improperly crimped cans. Further advancements focused on reinforcing communication between IoT devices and servers housing individual client's neural network weights. These weights are vital, ensuring the functionality of our IoT device. The efficiency of the IoT device in categorizing cans relies on updated neural network weights from the Fog server, crucial for continual refinement and adaptation to diverse can shapes. Securing communication integrity between devices and the server is imperative to avoid disruptions in can classification, emphasizing the need for secure channels. In this paper, our key scientific contribution revolves around devising a security protocol founded on HMAC. This protocol guarantees authentication and preserves the integrity of neural network weights exchanged between Fog computing nodes and IoT devices. The innovative addition of a comprehensive dictionary within the Fog server significantly bolsters security measures, enhancing the overall safety between these interconnected entities.

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Synthesis, Characterization, and Antibacterial Studies of New Cu(II) and Pd(II) Complexes with 6-Methyl-2-Thiouracil and 6-Propyl-2-Thiouracil

Cited by 4 publications

References 42 publications

Synthesis and Biological Activities of Some Metal Complexes of 2-Thiouracil and Its Derivatives: A Review

Synthesis and Biological Activities of Some Metal Complexes of 2-Thiouracil and Its Derivatives: A Review

Synthesis and Biological Activities of Some Metal Complexes of 2-Thiouracil and Its Derivatives: A Review

Enhancing Security Mechanisms for IoT-Fog Networks

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