New core configuration for the fabrication of 125I radioactive sources for cancer treatment

Souza, Carla Daruich de; Zeituni, Carlos A.; Costa, Osvaldo Luiz da; Angelocci, Lucas Verdi; Rostelato, Maria E.C.M.

doi:10.1016/j.apradiso.2020.109307

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…The authors affirm that if pH is kept high, the Na 125 I solution will remain stable not releasing the 125 I À for silver binding. Both of these issues were confirmed by Daruich de Souza et al [39].…”

Section: Characteristic Of the Isotope And Other Problems (Ph Reaction Volume Vial Type)supporting

confidence: 57%

Start Here When Performing Radiochemical Reactions

Souza¹,

Kim²,

Hong³

2022

Radiopharmaceuticals - Current Research for Better Diagnosis and Therapy

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Radiation products are present in several fields of knowledge. From the energy field, with nuclear reactors and nuclear batteries, to the medical field, with nuclear medicine and radiation therapy (brachytherapy). Although chemistry works in the same way for radioactive and non-radioactive chemicals, an extra layer of problems is present in the radiochemical counter-part. Reactions can be unpredictable due to several factors. For example, iodine-125 in deposited in a silver wire to create the core of a medical radioactive seed. This core is the sealed forming a radioactive seed that are placed inside the cancer. Several aspects can be discussed in regards to radiation chemistry. For example: are there any competing ions? Each way my reaction is going? Each reaction is more likely to occur? Those are important questions, because, in the case of iodine, a volatile product can be formed causing contamination of laboratory, equipment, personal, and environment. This chapter attempts to create a guideline on how to safely proceed when a new radioactive chemical reaction. It discusses the steps by giving practical examples. The focus is in protecting the operator and the environment. The result can be achieved safely and be reliable contribution to science and society.

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Section: Characteristic Of the Isotope And Other Problems (Ph Reaction Volume Vial Type)supporting

confidence: 57%

Start Here When Performing Radiochemical Reactions

Souza¹,

Kim²,

Hong³

2022

Radiopharmaceuticals - Current Research for Better Diagnosis and Therapy

Self Cite

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“…A capsule of biocompatible material that surrounds the core, most commonly titanium or stainless steel [ 15 ].…”

Section: Methodsmentioning

confidence: 99%

“…Depending to the treatment that the seed is being used, the seed activity will vary. For example, to treat prostate cancer Iodine-125 seed with activities averaging 30 MBq [ 15 ]. For use in RSL, several authors report activities between 1.10 to 13.00 MBq (0.03 to 0.35 mCi) [ 16 17 ].…”

Section: Methodsmentioning

confidence: 99%

Radioactive Seed Localization for Conservative Surgery of Nonpalpable Breast Cancer: Recommendations for Technology Implantation Program

Ferreira

Souza²,

Rostelato³

2022

International Journal of Surgery Protocols

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Background: The radioactive seed localization (RSL) is used in impalpable breast cancer conservative surgery to assist the surgeon in accurately locating and excising the lesion site. This study aims to present recommendations about the RSL program implementation in health institutions that perform breast cancer conservative surgery with intraoperative localization. Methods: An extensive literature review was performed. It comprehends: the committee responsible for implementation of the program actions; description of the necessary multidisciplinary team; the radiological safety committee role; the facility licensing; professionals training; material and instrumentation associated with the technique; and seed tracking system. Results: 13 topics are presented. The Program Implementation Committee must be formed by leaders from each department. The committee assumes responsibility for evaluating the necessary processes and presenting the schedule for program implementation. Since the procedure is classified as a nuclear medicine procedure it requires licensing . The Professional Team Formation, Education, and Training is a priority and simulation exercises are necessary. The Materials and Instrumentation Associated with the Technique must be well-know by the team and they should practice using radiation detectors. The seed must be always tracked, from moment they are received to discard. An Inventory for Tracking Seeds is provided. The Radiological Safety Aspects such as the ALARA principle are presented. A full description for the Radiological Procedure for Placing the seeds, the surgical removal and the Specimen Handling in Pathology focusing on how to locate the seed and retrieve them. After removed, the seeds can be placed in storage to wait for full radioactive decay or be returned to the manufacturer. Conclusions: The procedure has the advantage to increase to 2 months the time between insertion of the seed and the surgical removal. Regular multidisciplinary team meetings during program development are important to create a realistic timeline, having briefing meetings after the first 1-5 RSL cases and having annual or biannual follow-up meetings to discuss any issues or incidents. Abstract Graphic Image Created by Macrovector, obtained in Freepik at https://br.freepik.com/fotos-vetores-gratis/oncologia . Highlights This study present recommendations for RSL program implementation in hospitals Was performed by an extensive descriptive and qualitative literature review Topics 1: Implementation Committee, Professional Team Training, Instrumentation ...

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