Radioactive nanoparticles and their biomedical application in nanobrachytherapy

Souza, Carla Daruich de; Nogueira, Beatriz Ribeiro; Zeituni, Carlos A.; Rostelato, Maria E.C.M.

doi:10.1016/b978-0-12-820757-4.00012-0

Cited by 3 publications

(6 citation statements)

References 69 publications

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“…56,57 The possible explanation of obtained results can be associated with several factors, including metal ion complexation (known to be strong for L-cysteine, L-histidine, and L-methionine), the metal-binding affinity of amino acids to the metal surface, 55 and structure of intermediate decomposition (Scheme 2), which may or may not facilitate the further formation of AuNPs. 19,20,58−61 The reduction of HAuCl 4 with salts of 11 studied α-amino acids, 1−6, 12, 14, 15, 17, and 18, which constitute α-amino acids with aliphatic (Gly (1), Ala (2), Val (3), Leu (4), and Ile (5)), aromatic (Phe (6)), amidated (Asn ( 12)), hydroxylated (Ser (14) and Thr ( 15)), and acidic (Glu (17) and Asp ( 18)) side chains yielded mono-or polydisperse quasi-spherical AuNPs with sizes ranging from 10 to over 60 nm and different size distributions (Figures 1, 2, S1, and S2; Table 1). Considering the molecular structure of these 11 α-AA (no functional groups on side chains capable of reducing tetrachloroaurate ions) and the results of their reactions with HAuCl 4 , it can be confirmed that the rate-determining step of gold salts reduction with α-AA anions occurs via mechanism proposed in Scheme 2.…”

Section: ■ Results and Discussionmentioning

confidence: 60%

“…In our studies, we used for the synthesis of AuNPs salts of twenty-one α-amino acids (Chart 1). Among the used reagents were Lglycine (Gly) (1), L-alanine (Ala) (2), L-valine (Val) (3), Lleucine (Leu) (4), L-isoleucine (Ile) (5), DL-phenylalanine (Phe) (6), L-tryptophan (Trp) (7), L-methionine (Met) (8), L-proline (Pro) (9), L-cysteine (Cys) (10), L-glutamine (Gln) (11), L-asparagine (Asn) (12), L-tyrosine (Tyr) (13), L-serine (Ser) (14), DL-threonine (Thr) (15), L-(4)-hydroxyproline (Hyp) (16), L-glutamic acid (Glu) (17), L-aspartic acid (Asp) (18), L-histidine (His) (19), L-lysine (Lys) (20), and Larginine (Arg) (21). All investigated α-amino acids consist of a carboxyl group and an amine group in the α-position to it but differ in the side chain structure, giving each amino acid unique physicochemical properties (Table S2).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Gln (11) and Asn (12) adsorptions on the surface of the AuNPs take place through the amino group in the side chain. In the case of Ser (14) and Thr (15), their uptake on the surface of AuNPs occurs via the interaction of the OH group in their side chain through Au−O interaction. Glu (17) and Asp (18) interact with the surface of AuNPs via the carboxyl group in their side chain, which keeps amino acids close to the surface.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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α-Amino Acids as Reducing and Capping Agents in Gold Nanoparticles Synthesis Using the Turkevich Method

Figat,

Bartosewicz,

Liszewska

et al. 2023

Langmuir

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Amino acid-capped gold nanoparticles (AuNPs) are a promising tool for various applications, including therapeutics and diagnostics. Most often, amino acids are used to cap AuNPs synthesized with other reducing agents. However, only a few studies have been dedicated to using α-amino acids as reducing and capping agents in AuNPs synthesis. Hence, there are still several gaps in understanding their role in reducing gold salts. Here, we used 20 proteinogenic α-amino acids and one non-proteinogenic α-amino acid in analogy to sodium citrate as reducing and capping agents in synthesizing AuNPs using the Turkevich method. Only four of the twenty-one investigated amino acids have not yielded gold nanoparticles. The shape, size distribution, stability, and optical properties of synthesized nanoparticles were characterized by scanning electron microscopy, differential centrifugal sedimentation, the phase analysis light scattering technique, and UV−vis spectroscopy. The physicochemical characteristics of synthesized AuNPs varied with the amino acid used for the reduction. We proposed that in the initial stage of gold salts reduction most of the used α-amino acids behave similarly to citrate in the Turkevich method. However, their different physicochemical properties resulting from differences in their chemical structures significantly influence the outcomes of reactions.

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Section: ■ Results and Discussionmentioning

confidence: 60%

Section: ■ Results and Discussionmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

See 1 more Smart Citation

α-Amino Acids as Reducing and Capping Agents in Gold Nanoparticles Synthesis Using the Turkevich Method

Figat,

Bartosewicz,

Liszewska

et al. 2023

Langmuir

View full text Add to dashboard Cite

show abstract

“…As an alternative to NaBH 4 , we also explored reduction using ascorbic acid, heating, or irradiation with light at neutral pH and, besides Ag or Au NPs, we also prepared AgAu alloy NPs at a molar ratio of 1:1. 101 In all cases, NP synthesis in the presence of the polyampholytic graft copolymer was successful, resulting in stable dispersions of Ag, Au, and AgAu NPs (Figure 5). Although Ag NPs and Au NPs in all cases revealed their characteristic absorbance maxima at 415−420 and 525−550 nm, respectively, in case of the resulting alloys, this was found at 440−490 nm, indicating the formation of an alloy instead of both noble-metal NPs individually, because a physical mixture of both individual NPs would result in a bimodal distribution, as shown in Figure S6.…”

Section: ■ Results and Discussionmentioning

confidence: 93%

Polyampholytic Poly(dehydroalanine) Graft Copolymers as Smart Templates for pH-Controlled Formation of Alloy Nanoparticles

et al. 2020

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Polymer templates are a facile way to control the formation, size, and shape of different inorganic nanomaterials by tuning solution behavior, morphology, or density and the type of functional groups. As a novel class of such templates, we herein introduce polyampholytic graft copolymers, more specifically, poly(dehydroalanine)-graft-poly-(ethylene glycol) (PDha-g-PEG), which feature a polyampholytic backbone with varying net charge and charge densities at different pH values and PEG grafts, providing molecular solubility over the entire pH range. As the PDha backbone features both amino and carboxylic acid groups in each repeat unit, selective interaction with [AuCl 4 ]and Ag + salts is possible, and this permits a straightforward synthesis of Ag, Au, and AgAu alloy nanoparticles. In this regard, we used different approaches: light-induced, thermal, and chemical reduction. As a unique feature, PDha-g-PEG enables control over AgAu nanoalloy composition via the pH value, as this directly affects the charge ratio (−NH 3 + /−COO − ) along the polymeric backbone. The obtained hybrid materials were investigated with respect to structure, shape, composition, and optical properties of nanoparticles via transmission electron microscopy, X-ray photoelectron spectroscopy, energy-dispersive X-ray spectroscopy, thermogravimetric analysis, and UV−vis spectroscopy. In our opinion, this is a facile way to control nanoalloy composition and this can be extended to other mono-or bimetallic nanoparticle examples.

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“…Frequently, the reason for this is related to insufficient plasmonic signal enhancement generated by commercially available gold nanoparticles (AuNPs). Nanocolloids prepared by single-step approaches like laser ablation (no specificity in NP shape), 15 or more complex methods like thermal-based electrochemical reduction 16 (additional reducing agent involved) are not characterized by sufficient stability or adhesion on the supporting substrate. Analytical difficulties can be attributed to nonhomogeneous NP distribution over the surface, leading to problems with SERS hot-spot populations.…”

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confidence: 99%

Bacterial DNA Recognition by SERS Active Plasma-Coupled Nanogold

et al. 2022

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It is shown that surface-enhanced Raman spectroscopy (SERS) can identify bacteria based on their genomic DNA composition, acting as a “sample-distinguishing marker”. Successful spectral differentiation of bacterial species was accomplished with nanogold aggregates synthesized through single-step plasma reduction of the ionic gold-containing vapored precursor. A high enhancement factor (EF = 107) in truncated coupled plasmonic particulates allowed SERS-probing at nanogram sample quantities. Simulations confirmed the occurrence of the strongest electric field confinement within nanometric gaps between gold dimers/chains from where the molecular fingerprints of bacterial DNA fragments gained photon scattering enhancement. The most prominent Raman modes linked to fundamental base-pair molecular vibrations were deconvoluted and used to proceed with nitrogenous base content estimation. The genomic composition (percentage of guanine-cytosine and adenine-thymine) was successfully validated by third-generation sequencing using nanopore technology, further proving that the SERS technique can be employed to swiftly specify bioentities by the discriminative principal-component statistical approach.

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Radioactive nanoparticles and their biomedical application in nanobrachytherapy

Cited by 3 publications

References 69 publications

α-Amino Acids as Reducing and Capping Agents in Gold Nanoparticles Synthesis Using the Turkevich Method

α-Amino Acids as Reducing and Capping Agents in Gold Nanoparticles Synthesis Using the Turkevich Method

Polyampholytic Poly(dehydroalanine) Graft Copolymers as Smart Templates for pH-Controlled Formation of Alloy Nanoparticles

Bacterial DNA Recognition by SERS Active Plasma-Coupled Nanogold

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