New Constituents from the Leaves of Morinda citrifolia

Takashima, Junko; Ikeda, Yoshitaka; Komiyama, Kanki; Hayashi, Masahiko; Kishida, Akio; Ohsaki, Ayumi

doi:10.1248/cpb.55.343

Cited by 50 publications

(16 citation statements)

References 22 publications

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“…It has been used as an herbal plant with effectiveness on diabetes, hypertension and immunomodulation (Takashima et al, 2007). Schäfer et al (2008) showed the bactericidal effect against Escherichia coli in calves fed M. citrifolia (Noni) puree.…”

Section: Discussionmentioning

confidence: 99%

Investigation on Antibacterial and Antioxidant Activities, Phenolic and Flavonoid Contents of Some Thai Edible Plants as an Alternative for Antibiotics

Lee

Cho

Paik

et al. 2014

Asian Australas. J. Anim. Sci

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This study was aimed to examine the antibacterial and antioxidative properties of seven edible plants from Thailand to develop alternative antibiotics as feed additives. The plants include Citrus aurantifolia Swingle (Lime) fruits and its leaves, Sesbania grandiflora L. (Agati sesbania) leaves, Piper sarmentosum Roxb (Wild betal) leaves, Curcuma domestica Valeton (Turmeric) roots, Morinda citrifolia L. (Beach mulberry) leaves, Cassia siamea britt (Siamea cassia) leaves, and Cocos nucifera L. (Coconut) peels. The plants were extracted by methanol, n-hexane, chloroform, ethyl acetate, butanol and water. Antibacterial activities with minimum inhibitory concentration (MIC) were determined by agar diffusion assay against Escherichia coli, Burkholderia sp., Haemopilus somnus, Haemopilus parasuis, and Clostridium perfringens that were considered pathogenic strains in livestock infection. Methanol extracts of C. aurantifolia Swingle fruits and leaves showed the broadest spectrum of antibacterial activities except for C. perfringens. Butanol extract of S. grandiflora L. leaves showed the strongest activity against Burkholderia sp. with MIC, 135 μg/mL. P. sarmentosum Roxb leaves showed antibacterial activities against E. coli, Burkholderia sp. and H. parasuis. Ethyl acetate and water extracts from C. domesitca Valeton roots showed MIC of 306 μg/mL and 183 μg/mL, respectively against only C. perfringens. Antioxidative activity was determined by 2-diphenyl-2-picryl hydrazyl photometric assay. The methanol extracts of C. aurantifolia Swingle fruits and P. sarmentosum Roxb leaves showed the highest antioxidant activity among all the extracts with 3.46 mg/mL and 2.70 mg/mL effective concentration 50% (EC50) values, respectively. Total contents of phenolics and flavonoids were measured from the plant extracts. Methanol extracts of S. grandiflora L. and chloroform extracts of C. domestica Valeton were found to have the highest amount of total phenolics, 41.7 and 47.8 μg/mL, respectively. Flavonoid content of methanol extracts in S. grandiflora L. T was 22.5 μg/mL and the highest among plant extracts tested. These results indicated that C. aurantifolia Swingle, S. grandiflora L., P. sarmentosum Roxb, and C. domestica Valeton have antibacterial and antioxidant activities and can be used as alternative antibiotics or potential feed additives for the control of animal pathogenic bacteria.

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Section: Discussionmentioning

confidence: 99%

Investigation on Antibacterial and Antioxidant Activities, Phenolic and Flavonoid Contents of Some Thai Edible Plants as an Alternative for Antibiotics

Lee

Cho

Paik

et al. 2014

Asian Australas. J. Anim. Sci

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“…Some manufacturers also produce capsules containing powdered noni leaves 16 . Previous studies revealed that noni leaves contain a variety of phytochemical constituents, including terpenoid, phytosterol, iridoid, flavonol, and anthraquinone compounds and their glycoside derivatives [17][18][19] . Flavonoid compounds have been indicated to possess a variety of biological activities 20,21 , and may play an important role in noni leaves.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effect of Morinda citrifolia leaf extract on macrophage RAW 264.7 cells

Saraphanchotiwitthaya

Sripalakit²

2015

ScienceAsia

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Leaves of Morinda citrifolia (Rubiaceae) have been used in folk medicine to treat pain and inflammation. In this study, the anti-inflammatory activity of M. citrifolia leaf extracts was investigated. The extract was prepared by freeze-drying juice squeezed from M. citrifolia leaves. HPLC analysis of the crude extract revealed rutin to be a major compound together with small amounts of quercetin and kaempferol. The effect of this extract on TNF-α, IL-1β, and NO secretion by lipopolysaccharide-induced macrophage RAW 264.7 cells was investigated and compared to that of rutin, dexamethasone, and indomethacin. The results show that the extract inhibited TNF-α (98%, 750 µg/ml) secretion four times more than dexamethasone (3.92 µg/ml) and indomethacin (3.58 µg/ml), while rutin had no effect. The extract suppressed IL-1β secretion in a dose-dependent fashion with a maximum inhibition of about 79% (750 µg/ml). This was similar to that achieved by dexamethasone (97%, 3.92 µg/ml), indomethacin (70%, 3.58 µg/ml), and rutin (90%, 48.84 µg/ml). Moreover, the extract inhibited NO secretion (74%, 750 µg/ml) 50% more than rutin (40 µM) and 70% more than dexamethasone and indomethacin (10 µM). This study demonstrates the potential of M. citrifolia leaves as an effective therapeutic intervention against inflammatory diseases.

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“…Further, some compounds with antioxidant and anti-inflammatory activities, including those derived from plant extracts, have been found to reduce UV-induced erythema in human skin [12][13][14]. M. citrifolia leaves have been found to possess antioxidant activities [15,16], as well as to contain antiinflammatory compounds, such as E-phytol and deacetyl asperuloside [17,18]. As such, the current investigation was conducted to corroborate the traditional use of the leaves in treating topical inflammation, as well as to determine the utility of the leaf as a photoprotective agent.…”

Section: Introductionmentioning

confidence: 99%

Morinda citrifolia Linn. (Rubiaceae) leaf extracts mitigate UVB-induced erythema

West¹,

Deng²,

Palu³

et al. 2009

J Nat Med

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Morinda citrifolia Linn. (Rubiaceae) leaves have been used in tropical folk medicine to treat topical inflammation and burns. A carbomer gel base, containing the ethanol extract and juice pressed from the leaves, was evaluated for potential allergenic properties in a repeat-insult patch test in 49 volunteers. To investigate the topical photo-protective properties, the combined ethanol extract and leaf juice were evaluated in a UVB-induced erythema model in 25 volunteers. The crude ethanol extract of M. citrifolia leaves was also evaluated in vitro for potential anti-inflammatory activity in a histamine H-1 receptor antagonism assay. There was no evidence of allergenic potential in the repeat-insult patch test. When the combination of ethanol extract and leaf juice was applied, the UVB dose required to induce erythema was almost 3.5 times greater than with untreated skin (P < 0.001). In the histamine H-1 receptor-binding assay, the crude ethanol extract of M. citrifolia leaves inhibited receptor binding by 57%. These results suggest that M. citrifolia leaves are safe for topical use and may be useful in mitigating UVB-induced injury to the skin.

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New Constituents from the Leaves of Morinda citrifolia

Cited by 50 publications

References 22 publications

Investigation on Antibacterial and Antioxidant Activities, Phenolic and Flavonoid Contents of Some Thai Edible Plants as an Alternative for Antibiotics

Investigation on Antibacterial and Antioxidant Activities, Phenolic and Flavonoid Contents of Some Thai Edible Plants as an Alternative for Antibiotics

Anti-inflammatory effect of Morinda citrifolia leaf extract on macrophage RAW 264.7 cells

Morinda citrifolia Linn. (Rubiaceae) leaf extracts mitigate UVB-induced erythema

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