New condensed pyrroles of potential biological interest

Synthesis of New Pyrroles of Potential Anti‐Inflammatory Activity

“…The formation of compounds 4 was explained by the hydrolysis of cyano group on acidic medium to amide group without formation of the unstable diazonium salt on the amino group. In addition, this could be established chemically through hydrolysis of compound 1c, same compound 4c was obtained; 4c prepared by this method gave the same data as reported [23].…”

“…Column chromatography was performed on (Merck) Silica gel 60 (particle size 0.06-0.20 mm). Compounds 1a-c and 4c were prepared as reported in [14][15][16][17]23]. All new compounds yielded spectral data consistent with the proposed structure and microanalysis within AE0.4% of the theoretical values.…”

“…Compound 1 was prepared as reported in [14][15][16][17]23]. This compound was utilized for the preparation of pyrrole derivatives 2 and 3 using appropriate reagents and reaction conditions.…”

Synthesis, antimicrobial, antioxidant activities of novel 6-aryl-5-cyano thiouracil derivatives

“…midine-8-carbonitriles 5a-c and 7-aryl-3,5-dithioxo-2,3,5,6-tetrahydro [1,2,4]triazolo [4, 3-c]pyrimidine-8-carbonitriles6a-c,respectively [16,25,32,33]as revealed in scheme1.…”

“…These hydrazino derivatives exerted promising antibacterial, antifungal and anticancer activities [17][18][19]. In addition, the reactions of hydrazino pyrimidines with formic acid, trietylorthoformate(TEOF)and CS 2 (one carbon donor moieties) afforded the corresponding triazolopyrimidines [20][21][22][23][24][25],which are known to exhibit interesting Pharmaceutical activities [26,27]. In the light of the aforementioned facts, and in continuation for our interest in the synthesis of biologically active heterocyclic compounds, we report herein the synthesis and biological evaluation of novel 6-aryl-5-cyano thiouracil derivatives as antimicrobial and antioxidant agents.…”