New concepts in basement membrane biology

Halfter, Willi; Oertle, Philipp; Monnier, Christophe; Camenzind, Leon C.; Reyes‐Lua, Magaly; Hu, Huaiyu; Candiello, Joseph; Labilloy, Anatalia; Balasubramani, Manimalha; Henrich, P. B.; Plodinec, Marija

doi:10.1111/febs.13495

Cited by 128 publications

(109 citation statements)

References 100 publications

Supporting

Mentioning

102

Contrasting

Unclassified

Order By: Relevance

“…This approach, nevertheless, is not able to detect alterations in components of the ECM that are not observed at the ultrastructural level. Moreover, tissue processing for TEM reduces the actual thickness of BM, as demonstrated by atomic force microscopy [38]. Histochemistry and immunohistochemistry techniques, on the other hand, provide a more specific assessment of ECM components (Figure 1C,D), but the number of studies with SVMPs and hyaluronidases is limited (examples are [14,16,31,39,40]).…”

Section: Extracellular Matrix Pathology: An Elusive Aspect In the mentioning

confidence: 99%

A Comprehensive View of the Structural and Functional Alterations of Extracellular Matrix by Snake Venom Metalloproteinases (SVMPs): Novel Perspectives on the Pathophysiology of Envenoming

Gutiérrez

Escalante

Rucavado

et al. 2016

Toxins

View full text Add to dashboard Cite

Snake venom metalloproteinases (SVMPs) affect the extracellular matrix (ECM) in multiple and complex ways. Previously, the combination of various methodological platforms, including electron microscopy, histochemistry, immunohistochemistry, and Western blot, has allowed a partial understanding of such complex pathology. In recent years, the proteomics analysis of exudates collected in the vicinity of tissues affected by SVMPs has provided novel and exciting information on SVMP-induced ECM alterations. The presence of fragments of an array of ECM proteins, including those of the basement membrane, has revealed a complex pathological scenario caused by the direct action of SVMPs. In addition, the time-course analysis of these changes has underscored that degradation of some fibrillar collagens is likely to depend on the action of endogenous proteinases, such as matrix metalloproteinases (MMPs), synthesized as a consequence of the inflammatory process. The action of SVMPs on the ECM also results in the release of ECM-derived biologically-active peptides that exert diverse actions in the tissue, some of which might be associated with reparative events or with further tissue damage. The study of the effects of SVMP on the ECM is an open field of research which may bring a renewed understanding of snake venom-induced pathology.

show abstract

Section: Extracellular Matrix Pathology: An Elusive Aspect In the mentioning

confidence: 99%

A Comprehensive View of the Structural and Functional Alterations of Extracellular Matrix by Snake Venom Metalloproteinases (SVMPs): Novel Perspectives on the Pathophysiology of Envenoming

Gutiérrez

Escalante

Rucavado

et al. 2016

Toxins

View full text Add to dashboard Cite

show abstract

“…La microscopia de fuerza atómica (MFA) representa una técnica sólida que mide la rigidez tisular de las membranas basales, tales como la MLI a un nivel de nanoescala [8][9][10][11] . En el presente estudio experimental, utilizamos esta técnica para cuantificar los cambios potenciales de las propiedades biomecánicas de la MLI tras el tratamiento con ocriplasmina para maculopatías traccionales, tales como agujeros maculares o síndrome de TVM.…”

Section: Palabras Clave Membrana Limitante Interna · Ocriplasmina · Tunclassified

Propiedades biomecánicas de la membrana limitante interna tras recibir tratamiento intravítreo con ocriplasmina

Vielmuth¹,

Schumann²,

Spindler³

et al. 2017

Ophthalmologica

View full text Add to dashboard Cite

de las muestras de MLI extraídas de ojos con o sin tratamiento con ocriplasmina. Las áreas onduladas de la parte de la retina presentaron una mayor rigidez que la parte del vítreo de la MLI. La cartografía topográfica tanto de la parte del vítreo como de la retina de la MLI no mostró ninguna alteración aparente de la morfología en ojos tratados con ocriplasmina en comparación con los ojos no tratados. La tinción con azul brillante conllevó un aumento de la rigidez tisular. Conclusiones: Las inyecciones intravítreas de ocriplasmina no varían las propiedades biomecánicas de la MLI humana. No existen pruebas de un posible efecto enzimático que interfiera con la rigidez de esta membrana basal. © 2017 S. Karger AG, Basel IntroducciónLa ocriplasmina (Jetrea ® , ThromboGenics, Lovaina, Bélgica) constituye una forma truncada sin especificar y recombinante de la serina proteasa plasmina que posee actividad proteolítica frente a la laminina y fibronectina, ambos componentes principales de la interfase vitreore- Palabras clave Membrana limitante interna · Ocriplasmina · Tracción vitreomacularResumen Objetivo: Evaluar la rigidez de la membrana limitante interna (MLI) humana y evaluar los posibles cambios de las propiedades mecánicas tras administrar una inyección intravítrea de ocriplasmina para tratar la tracción vitreomacular. Métodos: Este estudio se compone de una serie de casos intervencionales y comparativos de 12 muestras de MLI extraídas mediante cirugía y obtenidas de forma consecutiva de 9 ojos de 9 pacientes después de someterse sin éxito a vitreólisis farmacológica con ocriplasmina. Durante el mismo periodo de tiempo, 16 muestras de otros 13 ojos sin tratamiento con ocriplasmina se obtuvieron mediante vitrectomía y sirvieron como controles. Todos los pacientes presentaron agujeros maculares o tracción vitreomacular y se sometieron a vitrectomía con disección de la MLI tanto con tinción con azul brillante (AB) como sin ella. Todas las muestras se analizaron con un microscopio de fuerza atómi-ca con imágenes de las regiones de 25 × 25 μm. En todas las muestras, se analizaron tanto la parte de la retina como la del vítreo de la MLI. Resultados: La microscopia de fuerza atómi-ca no reveló diferencias significativas en cuanto a elasticidad

show abstract

“…2). Animal epithelia also possess a basement membrane (see Glossary, Box 1) that mediates structural, developmental and defensive roles (Halfter et al, 2015). Such basement membranes contain characteristic proteins that provide a physical scaffold and regulate cell shape changes, cell adhesion or growth (Sherwood, 2015).…”

Section: Key Features Of An Epidermis: Cell Polarisation and Tight Cementioning

confidence: 99%

Developing a ‘thick skin’: a paradoxical role for mechanical tension in maintaining epidermal integrity?

et al. 2016

View full text Add to dashboard Cite

Plant aerial epidermal tissues, like animal epithelia, act as loadbearing layers and hence play pivotal roles in development. The presence of tension in the epidermis has morphogenetic implications for organ shapes but it also constantly threatens the integrity of this tissue. Here, we explore the multi-scale relationship between tension and cell adhesion in the plant epidermis, and we examine how tensile stress perception may act as a regulatory input to preserve epidermal tissue integrity and thus normal morphogenesis. From this, we identify parallels between plant epidermal and animal epithelial tissues and highlight a list of unexplored questions for future research.

show abstract

New concepts in basement membrane biology

Cited by 128 publications

References 100 publications

A Comprehensive View of the Structural and Functional Alterations of Extracellular Matrix by Snake Venom Metalloproteinases (SVMPs): Novel Perspectives on the Pathophysiology of Envenoming

A Comprehensive View of the Structural and Functional Alterations of Extracellular Matrix by Snake Venom Metalloproteinases (SVMPs): Novel Perspectives on the Pathophysiology of Envenoming

Propiedades biomecánicas de la membrana limitante interna tras recibir tratamiento intravítreo con ocriplasmina

Developing a ‘thick skin’: a paradoxical role for mechanical tension in maintaining epidermal integrity?

Contact Info

Product

Resources

About