New concept of a submillimetric pixellated Silicon detector for intracerebral application

Benoit, M.; Märk, Julia; Weiss, P.; Benoit, Didier; Clemens, J. C.; Fougeron, D.; Janvier, B.; Jevaud, M.; Karkar, S.; Menouni, M.; Pain, Frédéric; Pinot, L.; Morel, C.; Lanièce, P.

doi:10.1016/j.nima.2011.08.027

Cited by 2 publications

(1 citation statement)

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“…This enabled electronic stabilization of the pixels in terms of noise and gain and their isolation from the leakage current generated at the damaged edges of the probe. The structure efficiently controls the surface potential drop between the active part of the sensor and its dicing edge, though at the expense of an increase of sensor width of around 40% (Benoit et al 2011).…”

Section: Invasiveness Electronic Noise and Biocompatibilitymentioning

confidence: 99%

A wireless beta-microprobe based on pixelated silicon forin vivobrain studies in freely moving rats

Märk¹,

Benoit²,

Balasse³

et al. 2013

Phys. Med. Biol.

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The investigation of neurophysiological mechanisms underlying the functional specificity of brain regions requires the development of technologies that are well adjusted to in vivo studies in small animals. An exciting challenge remains the combination of brain imaging and behavioural studies, which associates molecular processes of neuronal communications to their related actions. A pixelated intracerebral probe (PIXSIC) presents a novel strategy using a submillimetric probe for beta(+) radiotracer detection based on a pixelated silicon diode that can be stereotaxically implanted in the brain region of interest. This fully autonomous detection system permits time-resolved high sensitivity measurements of radiotracers with additional imaging features in freely moving rats. An application-specific integrated circuit (ASIC) allows for parallel signal processing of each pixel and enables the wireless operation. All components of the detector were tested and characterized. The beta(+) sensitivity of the system was determined with the probe dipped into radiotracer solutions. Monte Carlo simulations served to validate the experimental values and assess the contribution of gamma noise. Preliminary implantation tests on anaesthetized rats proved PIXSIC's functionality in brain tissue. High spatial resolution allows for the visualization of radiotracer concentration in different brain regions with high temporal resolution.

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Section: Invasiveness Electronic Noise and Biocompatibilitymentioning

confidence: 99%