New Compounds. p-Fluorophenacyl Bromide Salts

Bahner, Carl Tabb; Easley, William K.; Walden, Betty Gay; Lyons, Harold; Biggerstaff, George E.

doi:10.1021/ja01135a600

Cited by 8 publications

(2 citation statements)

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“…Yield 70 % as colourless plates; m.p. 260−261°C; UV (MeOH): λ max 259, 202; IR (KBr): ν max cm -1 3420, 3110, 2910, 1700, 1620, 1580, 1340; 1…”

Section: -Carboxy-1-(4'-methylphenacyl)-pyridinium Bromide (2)mentioning

confidence: 99%

“…In the past, phenacyl halide quaternary salts of pyridine, picoline, nicotinamide, ethylnicotinate, quinoline and 3-methylisoquinoline were synthesized for testing their biological activities [1,2] whereas pyridine derivatives also have been investigated for a wide variety of biological aspects including cholesterol-solubilizing [3], oral hypoglycemic [4−8], antitumor [9−13], antibacterial and antimicrobial activities [14−16]. Recently, one of the derivatives of nicotinic acid, 1,2-dihydro-2-oxo-6-(2,2dimethylpropyl)-3-pyridinecarboxylic acid (U-56324), showed hypoglycemic activity in 18 h fasting normal rats and in vitro stimulation of insulin secretion [17− 19].…”

Section: Introductionmentioning

confidence: 99%

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Syntheses, Antibacterial, Cytotoxic and Antifungal Effects of New 3-Carboxy-1-phenacylpyridinium Salts

Khan

Saify

Shah

et al. 2011

Arzneimittelforschung

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Thirteen pyridine-3-carboxylic acid salt derivatives with various substituted phenacyl residues were prepared and their cytotoxicity, antibacterial and antifungal activities tested. Compounds 5 and 11 proved to be active in the brine shrimp bioassay, compounds 7, 9-12 and 14 showed promising antibacterial activities, whereas none of the compounds tested against 15 fungal cultures proved to be active. Extensive spectroscopic techniques were employed to confirm the structure of the synthetic products.

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“…Yield 70 % as colourless plates; m.p. 260−261°C; UV (MeOH): λ max 259, 202; IR (KBr): ν max cm -1 3420, 3110, 2910, 1700, 1620, 1580, 1340; 1…”

Section: -Carboxy-1-(4'-methylphenacyl)-pyridinium Bromide (2)mentioning

confidence: 99%