New composites of betulin esters with arabinogalactan as highly potent anti-cancer agents

Шахтшнейдер, Т. П.; Кузнецова, Светлана А.; Zamay, Anna S.; Zamay, Tatyana N.; Spivak, E. A.; Михайленко, М. А.; Malyar, Yuriy N.; Кузнецов, Б.Н.; Чесноков, Николай В.; Болдырев, В. В.

doi:10.1080/14786419.2015.1060591

Cited by 17 publications

(4 citation statements)

References 14 publications

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“…This triterpene shows potent activity against several bacterial species such as S. aureus , Enterococcus faecalis , S. mutans, S. sobrinus and Mycobacterium tuberculosis [ 233 , 234 , 235 ]. Unfortunately, low solubility and stability of ursolic acid in aqueous medium hinder its therapeutic application and require the development of water-soluble formulations [ 230 , 236 ].…”

Section: Triterpenesmentioning

confidence: 99%

Secondary Metabolites with Biomedical Applications from Plants of the Sarraceniaceae Family

Miclea

2022

IJMS

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Carnivorous plants have fascinated researchers and hobbyists for centuries because of their mode of nutrition which is unlike that of other plants. They are able to produce bioactive compounds used to attract, capture and digest prey but also as a defense mechanism against microorganisms and free radicals. The main purpose of this review is to provide an overview of the secondary metabolites with significant biological activity found in the Sarraceniaceae family. The review also underlines the necessity of future studies for the biochemical characterization of the less investigated species. Darlingtonia, Heliamphora and Sarracenia plants are rich in compounds with potential pharmaceutical and medical uses. These belong to several classes such as flavonoids, with flavonol glycosides being the most abundant, monoterpenes, triterpenes, sesquiterpenes, fatty acids, alkaloids and others. Some of them are well characterized in terms of chemical properties and biological activity and have widespread commercial applications. The review also discusses biological activity of whole extracts and commercially available products derived from Sarraceniaceae plants. In conclusion, this review underscores that Sarraceniaceae species contain numerous substances with the potential to advance health. Future perspectives should focus on the discovery of new molecules and increasing the production of known compounds using biotechnological methods.

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Section: Triterpenesmentioning

confidence: 99%

Secondary Metabolites with Biomedical Applications from Plants of the Sarraceniaceae Family

Miclea

2022

IJMS

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“…AG can serve as a targeted carrier for the delivery of diagnostic and therapeutic agents, as well as enzymes, nucleic acids, vitamins or hormones to specific cells [3][4][5][6]. AG is used in medicine in the treatment of various gastrointestinal diseases [7], has adhesive properties and exhibits antimicrobial [8], antimycobacterial [9], antioxidant and immunological [10], antiviral [11] and anticancer [12] activity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Root Forming Activity of Inclusion Complexes of Heterocyclic Thioanhydrides With Arabinogaltan

Sycheva¹,

Anuarbekova²,

Markina³

et al. 2023

Chem. J. of Kaz.

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Nitrogen-containing heterocycles are structural elements of many synthetic and endogenous biologically active substances. In this regard, they have particular interest as objects of study of the relationship between the structure and biological activity. The aim of this work is the development of new plant growth stimulants, based on nitrogen-containing heterocyclic dithiocarbamic acids and their inclusion complexes with arabinogalactan, and the study of their root-forming activity. Results and discussion. Synthesis of sodium dithiocarbamate of 5-amino-1,3,4-thiadiazole-2-thiol and its carbonyl derivatives cycloprapane, 4-fluoro- and 4-methoxybenzoic thioanhydrides has been carried out. Conditions for synthesis of the inclusion complexes of thioanhydrides 2-4 with arabinogalactan (AG) have been developed. The synthesis of the bioorganic inclusion complexes of substrates with AG has been carried out in the mass ratio of the initial reagents 1:1 in dimethyl sulfoxide, the duration of the reactions has been 8 hours at the temperature of 55-60 °C. The inclusion complexes with arabinogalactan have been obtained with the yield of 62-88%. The structure of the synthesized heterocyclic thioanhydrides has been established based on IR and 1H and 13C NMR spectroscopy. Field tests have been carried out to identify the root-forming activity of the obtained compounds and to determine the effect of the growth stimulants on the growth of the root system of vangutta spirea cuttings. Conclusion. It has been found that biocomplex 4-methoxybenzoic (5-mercapto-1,3,4-thiadiazol-2-yl)carbamothioic thioanhydride with arabinogalactan 7 increases the rooting and survival of the planting material and at the concentration of 100 mg/l shows a high yield of the rooted spirea cuttings (90%), as compared with the control (13% ) and standards Kornevin (20%) and AN-16 (36%).

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“…Its potent biological activity and immune-enhancing properties have received increased attention as a clinically useful nutraceutical agent (25). AG has several properties which make it an ideal adjunct supplement to be considered in cancer protocols (26). Aqueous extract of T. cordifolia is enriched in the polysaccharide fraction containing AG when compared with other types of extract (27).…”

Section: Introductionmentioning

confidence: 99%

Anticancer potential of Tinospora cordifolia and arabinogalactan against benzo(a)pyrene induced pulmonary tumorigenesis: a study in relevance to various biomarkers

Mohan¹,

Koul²

2018

J Herbmed Pharmacol

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Tinospora cordifolia plant and its various bioactive components have wide range of pharmacological properties. Aqueous extract of Tinospora cordifolia stem and arabinogalactan (AG), its bioactive polysaccharide, act as anti-cancer agents and have the potential for preparation of new drugs against lung cancer. Please cite this paper as: Mohan V, Koul A. Anticancer potential of Tinospora cordifolia and arabinogalactan against benzo(a) pyrene induced pulmonary tumorigenesis: a study in relevance to various biomarkers.

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New composites of betulin esters with arabinogalactan as highly potent anti-cancer agents

Cited by 17 publications

References 14 publications

Secondary Metabolites with Biomedical Applications from Plants of the Sarraceniaceae Family

Secondary Metabolites with Biomedical Applications from Plants of the Sarraceniaceae Family

Synthesis and Root Forming Activity of Inclusion Complexes of Heterocyclic Thioanhydrides With Arabinogaltan

Anticancer potential of Tinospora cordifolia and arabinogalactan against benzo(a)pyrene induced pulmonary tumorigenesis: a study in relevance to various biomarkers

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