No abstract

Nitrogen-containing heterocycles are structural elements of many synthetic and endogenous biologically active substances. In this regard, they have particular interest as objects of study of the relationship between the structure and biological activity. The aim of this work is the development of new plant growth stimulants, based on nitrogen-containing heterocyclic dithiocarbamic acids and their inclusion complexes with arabinogalactan, and the study of their root-forming activity. Results and discussion. Synthesis of sodium dithiocarbamate of 5-amino-1,3,4-thiadiazole-2-thiol and its carbonyl derivatives cycloprapane, 4-fluoro- and 4-methoxybenzoic thioanhydrides has been carried out. Conditions for synthesis of the inclusion complexes of thioanhydrides 2-4 with arabinogalactan (AG) have been developed. The synthesis of the bioorganic inclusion complexes of substrates with AG has been carried out in the mass ratio of the initial reagents 1:1 in dimethyl sulfoxide, the duration of the reactions has been 8 hours at the temperature of 55-60 °C. The inclusion complexes with arabinogalactan have been obtained with the yield of 62-88%. The structure of the synthesized heterocyclic thioanhydrides has been established based on IR and 1H and 13C NMR spectroscopy. Field tests have been carried out to identify the root-forming activity of the obtained compounds and to determine the effect of the growth stimulants on the growth of the root system of vangutta spirea cuttings. Conclusion. It has been found that biocomplex 4-methoxybenzoic (5-mercapto-1,3,4-thiadiazol-2-yl)carbamothioic thioanhydride with arabinogalactan 7 increases the rooting and survival of the planting material and at the concentration of 100 mg/l shows a high yield of the rooted spirea cuttings (90%), as compared with the control (13% ) and standards Kornevin (20%) and AN-16 (36%).

doctor of chemistry, professor, academician of NAS RK, president of NAS RK, general director of JSC "Institute of fuel, catalysis and electrochemistry named after D.V. Sokolsky (Almaty, Kazakhstan) H = 4 Editorial board: ADEKENOV Sergazy Mynzhasarovich (deputy editor-in-chief) doctor of chemical sciences, professor, academician of NAS RK, director of the international Scientific and production holding «Phytochemistry» (Karaganda, Kazakhstan) H = 11 AGABEKOV Vladimir Enokovich (deputy editor-in-chief), doctor of chemistry, professor, academician of NAS of Belarus, honorary director of the Institute of Chemistry of new materials (Minsk, Belarus) H = 13 STRNAD Miroslav, head of the laboratory of the institute of Experimental Botany of the Czech academy of sciences, professor (Olomouc, Czech Republic) H = 66 BURKITBAYEV Mukhambetkali, doctor of chemistry, professor, academician of NAS RK, first vice-rector of al-Farabi KazNU (Almaty, Kazakhstan) H = 11 HOHMANN Judith, head of the department of pharmacognosy, faculty of Pharmacy, university of Szeged, director of the interdisciplinary center for Life sciences (Szeged, ungary) H = 38 ROSS Samir, Ph.D, professor, school of Pharmacy, national center for scientific research of Herbal Products, University of Mississippi (Oxford, USA) H = 35 KHUTORYANSKY Vitaly, Ph.D, pharmacist, professor at the University of Reading (Reading, England) H = 40 TELTAYEV Bagdat Burkhanbayuly, doctor of technical sciences, professor, corresponding member of NAS RK, ministry of Industry and infrastructure development of the Republic of Kazakhstan (Almaty, Kazakhstan) H = 13 PHARUK Asana Dar, professor at Hamdard al-Majid college of Oriental medicine. faculty of Oriental medicine, Hamdard university (Karachi, Pakistan) H = 21 FAZYLOV Serik Drakhmetovich, doctor of chemistry, professor, academician of NAS RK, deputy director for institute of Organic synthesis and coal chemistry (Karaganda, Kazakhstan) H = 6 ZHOROBEKOVA Sharipa Zhorobekovna, doctor of chemistry, professor, academician of NAS of Kyrgyzstan, Institute of Chemistry and chemical technology of NAS KR (Bishkek, Kyrgyzstan) H = 4 KHALIKOV Jurabay Khalikovich, doctor of chemistry, professor, academician of the academy of sciences of tajikistan, institute of Chemistry named after V.I. Nikitin AS RT (Tajikistan) H = 6 FARZALIEV Vagif Medzhid ogly, doctor of chemistry, professor, academician of NAS of Azerbaijan (Azerbaijan) H = 13 GARELIK Hemda, PhD in chemistry, president of the department of Chemistry and Environment of the International Union of Pure and Applied Chemistry (London, England) H = 15 News of the National Academy of Sciences of the Republic of Kazakhstan. Series of chemistry and technology.

Interest in numerous naphthylamine derivatives is due to a wide range of their biological activity (growth-stimulating, antimicrobial, anticancer, antiviral, antihypertensive, antidiabetic, etc.). The aim of the workis the synthesis of biologically active N,S,O-containing substances in the series of acetylenic, alkoxy- and aroxyalkyl esters of naphthylamine. Study of acylation, propargylation and alkylation reactions of naphthalene-1-yl-bis(sodium carbamodiothioate). Methodology. New derivatives of naphthylbisdithiocarbamic acid were synthesized as a result of the modification of disubstituted α-naphthylaminedithiocarbamate. It was shown that the interaction of α-naphthylaminebisdithiocarbamate with benzoic acid chloride, propargyl bromide and alkyl halides (2-methoxyethyl, 2-ethoxyethyl, 2-phenoxyethyl, 3-phenoxypropyl) leads to the formation of the corresponding thioanhydride, dithioacetylenic, alkoxy- and aroxyalkyl esters of naphthylbisdithiocarbamic acid. Synthesis was carried out in acetone at room temperature for 1.5 – 3 h. Reaction coursewas monitored by TLC method. Results and discussion. It was established that propargylation, acylation and alkylation reactions of α-naphthylaminedithiocarbamine derivative proceed easily and with high yields (66 − 91%). The structure of the synthesized compounds was established based on the data of elemental analysis and 1H and 13C NMR spectroscopy. Thus, were synthesized new potentially biologically active naphthylbisdithiocarbamic acid derivatives, combining pharmacophore groups in their structure.

Propargylic Sulfides: Synthesis, Properties, and Application -[333 refs.]. -(VIZER, S. A.; SYCHEVA, E. S.; AL QUNTAR, A. A. A.; KURMANKULOV, N. B.; YERZHANOV, K. B.; DEMBITSKY, V. M.; Chem. Rev. (Washington, DC, U. S.) 115 (2015) 3, 1475-1502, http://dx.doi.org/10.1021/cr4001435 ; Bekturov Inst. Chem. Sci., Natl. Acad. Sci., Almaty 480100, Kazakhstan; Eng.) -Koehler 17-311