New complexes of manganese (II) and copper (II) derived from the two new furopyran-3, 4-dione ligands: Synthesis, spectral characterization, ESR, DFT studies and evaluation of antimicrobial activity

Abdi, Yamina; Bensouilah, Nadjia; Siziani, Dhaouya; Hamdi, Maâmar; Silva, Artur M. S.; Boutemeur-Kheddis, Baya

doi:10.1016/j.molstruc.2019.127307

Cited by 17 publications

(9 citation statements)

References 71 publications

(80 reference statements)

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“…The complexes crystallize in the space group P6 3 /m of the hexagonal crystal system. [ 41 ] The three complexes are isomorphic. Taking [Nd 2 (L) 3 · H 2 O] n as an example, the coordination environment of the complex is shown in Figure 2a.…”

Section: Resultsmentioning

confidence: 99%

Three novel spiral chain Nd (III) Eu (III) Sm (III)complexes bridged by 1,1 '(1,4‐phenylene‐bis [methylene])‐bis (pyridine‐3‐carboxylicaicd): Synthesis, structural characterization, and antitumor activity

Liu

et al. 2021

Applied Organom Chemis

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In this work, three new complexes [Ln2(L)3·H2O]n (where Ln = Nd(1)、Eu (2) and Sm (3)) have been synthesized by H2L (H2L = 1,1 ‘(1,4‐phenylene‐ bis [methylene])‐bis (pyridine‐3‐carboxylicaicd)) and were characterized by X‐ray single crystal diffraction and PXRD. The interaction of these complexes with FS DNA (fish sperm DNA) and the DNA binding constants of the complexes were determined using UV spectroscopy, indicating their ability to bind to FS DNA. The DNA binding constants k of the three complexes were 1.0186 × 104, 5.047 × 103, and 5.115 × 103, respectively. The results of UV spectrum showed that the complex 1–3 was bound to DNA through hydrogen bonding. The interaction of the complexes with FS DNA was studied by fluorescence spectroscopy. The stern‐volmer quenching values of complexes 1, 2, and 3 were 0.186, 0.093, and 0.114, respectively. Electrophoresis experiments showed that the three complexes could cleave DNA molecules. In addition, flow cytometry, and morphological apoptosis studies showed that the complex could induce apoptosis of HeLa tumor cells. Results all the three complexes had potential medicinal value.

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Section: Resultsmentioning

confidence: 99%

Three novel spiral chain Nd (III) Eu (III) Sm (III)complexes bridged by 1,1 '(1,4‐phenylene‐bis [methylene])‐bis (pyridine‐3‐carboxylicaicd): Synthesis, structural characterization, and antitumor activity

Liu

et al. 2021

Applied Organom Chemis

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“…Comparison of copper complexes with other metal complexes generally indicates that copper compounds are more effective antibacterial and/or antifungal agents [11,14,25,30,32,33,39,41,42,56]. This can be associated with such a distinctive feature of copper as its ability to redox transformations.…”

Section: Discussionmentioning

confidence: 99%

“…In general, the copper (36a) and manganese complexes (36b) derived from the HL 36 ligand are more active than the HL 37 ligand complexes (37a and 37b). The authors [41] note that this antimicrobial behavior is related to the electronic effect of the substituents. It was found that the ligands and their metallic complexes exhibit excellent antifungal activity against C. albicans and Candida tropicalis (C. tropicalis).…”

Section: N-donor Ligandsmentioning

confidence: 99%

“…O,O-DONOR LIGANDS Four new metal complex (36a, 36b and 37a, 37b) derivatives of two new ligands 2-(hydroxy(phenyl)-6-methyl-2H-furo[3,2-c]pyran-3,4-dione (HL 36 ) and 2-(hydroxyl(2-hydroxyphenyl)-6-methyl-2Hfuro[3,2-c]pyran-3,4-dione (HL 37 ) with the metal ions Mn(II) and Cu(II) have been successfully prepared in alcoholic medium [41]. The copper complex 36a showed an important activity than that of the ligand HL 36 namely an excellent antibacterial activity against Gram-positive bacteria (S. aureus, group D Streptococcus) and a moderate activity against Gram-negative bacteria (E. coli, K. pneumonia).…”

Section: N-donor Ligandsmentioning

confidence: 99%

“…(HL 39 ), p-methylphenyl (HL40 ), p-chlorolphenyl (HL41 ), p-nitrophenyl (HL42 ), furan (HL43 ), pyrrol (HL44 ) …”

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Recent Studies on the Antimicrobial Activity of Copper Complexes

Zalevskaya

Gur’eva

2021

Russ J Coord Chem

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The analysis of publications in 2020, devoted to the synthesis of copper(II) complexes and the study of their antimicrobial properties, indicates that this area of medicinal chemistry is promising. Organic compounds of various classes were studied as starting ligands. First of all, these are N-donor imines, amines, heterocyclic compounds, as well as N,O-donor ligands and sulfur-containing ligands. In most works, the fact of a higher biological activity of the metal complex in comparison with the corresponding ligand was established. Evaluating the influence of the nature of the metal on the antimicrobial activity of the metal complex, the authors most often come to the conclusion that it is copper(II) complexes that are the most effective inhibitors of the growth of pathogenic bacteria. The scale of the studies presented indicates a high interest in this group of metal complexes, and the results indicate good prospects for using copper complexes as antimicrobial drugs.

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Synthesis, Characterization and Biological Properties of Mn (II) and Cu (II) Complexes with Sulfonamide and Imidazole Derivatives: Genotoxicity, ADME Profile, and Molecular Docking Studies**

Bouchoucha,

Amine Bourouai,

Si Larbi

et al. 2023

ChemistrySelect

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The synthesis, characterization, and comparative biological properties of manganese (II) and copper (II) complexes formed with two heterocyclic ligands used in the pharmaceutical field are reported. The characterization of the metal complexes involved elemental analysis, FAB mass spectroscopy, ESR, FTIR, UV‐Visible spectroscopy, and conductometry. The spectroscopic data allowed the determination of the coordination mode and the geometry of all the coordination compounds.

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New complexes of manganese (II) and copper (II) derived from the two new furopyran-3, 4-dione ligands: Synthesis, spectral characterization, ESR, DFT studies and evaluation of antimicrobial activity

Cited by 17 publications

References 71 publications

Three novel spiral chain Nd (III) Eu (III) Sm (III)complexes bridged by 1,1 '(1,4‐phenylene‐bis [methylene])‐bis (pyridine‐3‐carboxylicaicd): Synthesis, structural characterization, and antitumor activity

Three novel spiral chain Nd (III) Eu (III) Sm (III)complexes bridged by 1,1 '(1,4‐phenylene‐bis [methylene])‐bis (pyridine‐3‐carboxylicaicd): Synthesis, structural characterization, and antitumor activity

Recent Studies on the Antimicrobial Activity of Copper Complexes

Synthesis, Characterization and Biological Properties of Mn (II) and Cu (II) Complexes with Sulfonamide and Imidazole Derivatives: Genotoxicity, ADME Profile, and Molecular Docking Studies**

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