New Coll–HA/BT composite materials for hard tissue engineering

Zanfir, Andrei Vlad; Voicu, Georgeta; Busuioc, Cristina; Jinga, Sorin‐Ion; Albu, Mădălina Georgiana; Iordache, Florin

doi:10.1016/j.msec.2016.02.041

Cited by 29 publications

(16 citation statements)

References 37 publications

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“…Furthermore, composites based on the piezoelectric component of bone, collagen (fibrilar bovine Coll type I), have also been used to fabricate materials for bone substitute [267,268].…”

Section: Piezoelectric Nanofibre Fabricationmentioning

confidence: 99%

“…Zanfir et al demonstrated that use of BT in combination of collagen and hydroxyapatite ensured that the composite scaffolds exhibit osteoconductive properties [268]. The composite scaffolds were fabricated by mixing collagen gel with mineral phase (HA/HA+BT) followed by chemically crosslinking, freezing and freeze-drying.…”

Section: Piezoelectric Nanofibre Fabricationmentioning

confidence: 99%

“…The composite scaffolds were fabricated by mixing collagen gel with mineral phase (HA/HA+BT) followed by chemically crosslinking, freezing and freeze-drying. The improved osteoconductivity was attributed to the incorporation BT nanopowder in the composites [268]. However, the study did not include any polarization treatment of scaffolds to induce piezoelectricity, which might further add to the functionality of the scaffolds and improve cellular response.…”

Section: Piezoelectric Nanofibre Fabricationmentioning

confidence: 99%

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Piezoelectric materials as stimulatory biomedical materials and scaffolds for bone repair

2018

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Electrical stimulation/electrical microenvironment are known effect the process of bone regeneration by altering the cellular response and are crucial in maintaining tissue functionality. Piezoelectric materials, owing to their capability of generating charges/potentials in response to mechanical deformations, have displayed great potential for fabricating smart stimulatory scaffolds for bone tissue engineering. The growing interest of the scientific community and compelling results of the published research articles has been the motivation of this review article. This article summarizes the significant progress in the field with a focus on the fabrication aspects of piezoelectric materials. The review of both material and cellular aspects on this topic ensures that this paper appeals to both material scientists and tissue engineers.

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“…Furthermore, composites based on the piezoelectric component of bone, collagen (fibrilar bovine Coll type I), have also been used to fabricate materials for bone substitute [267,268].…”

Section: Piezoelectric Nanofibre Fabricationmentioning

confidence: 99%

Section: Piezoelectric Nanofibre Fabricationmentioning

confidence: 99%

Section: Piezoelectric Nanofibre Fabricationmentioning

confidence: 99%

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Piezoelectric materials as stimulatory biomedical materials and scaffolds for bone repair

2018

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“…The earliest implants were handcrafted out of animal bone and, later on, diverse materials, like natural polymers (gutta-percha [7], rubber [8], cellulose [9], collagen [10]), were employed with varying degrees of success. Depending on specific applications and according to the mechanical requirements, there are competing materials, such as ceramics [11][12][13] and composites [14]. However, for implants that experience large flexural loads, a metal is always required.…”

Section: Introductionmentioning

confidence: 99%

Development of Vitroceramic Coatings and Analysis of Their Suitability for Biomedical Applications

et al. 2019

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Within the field of tissue engineering, thin films have been studied to improve implant fixation of metallic or ceramic materials in bone, connective tissue, oral mucosa or skin. In this context, to enhance their suitability as implantable devices, titanium-based substrates received a superficial vitroceramic coating by means of laser ablation. Further, this study describes the details of fabrication and corresponding tests in order to demonstrate the bioactivity and biocompatibility of the newly engineered surfaces. Thus, the metallic supports were covered with a complex material composed of SiO 2 , P 2 O 5 , CaO, MgO, ZnO and CaF 2 , in the form of thin layers via a physical deposition techniques, namely pulsed laser deposition. The resulting products were characterized by X-ray diffraction, Fourier-transform infrared spectroscopy, scanning and transmission electron microscopy coupled with energy dispersive X-ray spectroscopy, selected area electron diffraction, and electron energy loss spectroscopy. It was found that a higher substrate temperature and a lower working pressure lead to the highest quality film. Finally, the samples biocompatibility was assessed and they were found to be bioactive after simulated body fluid soaking and biocompatible through the MTT cell viability test.Coatings 2019, 9, 671 2 of 13 drawbacks, like fibrous tissue growth, slow osseointegration and reduced close contact with the host bone, were noticed upon wider use of titanium alloy implants [19]. Thus, the quest is to develop a composite material with all the mechanical properties of titanium alloys, encapsulated in a leak-proof ceramic, that can be biologically preactivated prior to implant [20,21].With the advent of laser-based additive manufacturing [22], such composite material is now a reality. In this case, a commercial or custom-made ceramic target is ablated by a pulsed laser, a plume of plasma is generated and directed towards the metallic substrate, upon which it settles, forming a thin layer that physically binds to the support [23,24]. Our research group has already reported the growth of nanostructured akermanite-based thin films by pulsed laser deposition, with good biocompatibility and bioactivity [25]. Since both the target characteristics and processing conditions strongly influence the properties of the final coatings [26], more studies are necessary in order to elucidate which are the driven factors and optimized set of parameters.Thus, the aim of this work is to produce a material that is durable and readily implantable. A type of vitroceramic coatings on titanium substrates were developed, characterized and then immersed in simulated biological fluid to be coated with a hydroxyapatite-like layer and demonstrate its bioactivity [27,28]. Further biological tests indicated that, indeed, this combination of materials resulted in an artifact that responds well to the in vitro cell proliferation. Author Contributions: Conceptualization, S.-I.J. and C.B.; methodology, C.B. and D.M.; validation, S.-I.J.; investigation...

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“…An in vitro study of osteoblast-like cells, cultured on poled and unpoled HABT ceramics, demonstrated cell proliferation on intimate contact with the material, evidencing the biocompatibility in vitro of this material [5]. Zanfir et al [17] studied a collagen-HA/BT composite and attributed the excellent in vitro osteoinductive properties to the ferromagnetic properties of BaTiO 3 .…”

Section: Introductionmentioning

confidence: 99%

Promotion of bone repair of rabbit tibia defects induced by scaffolds of $$\hbox {P(VDF-TrFE)/BaTiO}_{3}$$ composites

et al. 2019

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In this work, scaffolds made of a novel experimental 0-3 type composite were implanted onto non-critical defects in rabbit tibiae. This work discusses the bone repair promoted by polyvinylidene fluoride-trifluoroethylene P(VDF-TrFE)/barium titanate (BaTiO 3) composite that scaffolds with 10 vol% BaTiO 3. Prior to implant surgery, the P(VDF-TrFE)/BaTiO 3 scaffolds, moulded into a membrane disk, were subjected to a cytotoxicity test (ASTM F895-84). A standardized transverse osteotomy was made with the following dimensions: 4.5 mm in width by 9 mm in length, at the proximal tibial metaphysis, in adult male rabbits, by using a cylindrical drill, cooled with a physiologic solution. These critical defects were filled with blood clot on the left tibiae (control group), whereas the right tibiae were covered with composite scaffolds, measuring 5 mm in thickness and 10 mm in diameter (experimental group); n = 12 for each group. After 21 days, the rabbits were sacrificed and the tibiae bone fragments were conducted to demineralization routines, from fixation and stain procedures to histological analysis. The scaffolds promote the growth of the bone, resulting in an increased repair with callus formation around the scaffold and high mitotic activity at newly formed bones.

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New Coll–HA/BT composite materials for hard tissue engineering

Cited by 29 publications

References 37 publications

Piezoelectric materials as stimulatory biomedical materials and scaffolds for bone repair

Piezoelectric materials as stimulatory biomedical materials and scaffolds for bone repair

Development of Vitroceramic Coatings and Analysis of Their Suitability for Biomedical Applications

Promotion of bone repair of rabbit tibia defects induced by scaffolds of $$\hbox {P(VDF-TrFE)/BaTiO}_{3}$$ composites

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