New class of potent antinociceptive and antiplatelet 10H-phenothiazine-1-acylhydrazone derivatives

Biological Activities of Hydrazone Derivatives

“…Additionally, the change in para-substituent group of acylhydrazone framework permitted to identify a hydrophilic carboxylate derivative and a hydrophobic bromo derivative as two new analgesics that are more potent than dipyrone, which is the standard, possessing selective peripheral or central mechanism of action [25]. Gökhan-Kelekçi et al synthesized hydrazones containing 5-methyl-2-benzoxazoline.…”

Crystal structure of N 2,N 6-bis(1-hydrazinyl-2-methyl-1-oxopropan-2-yl) pyridine-2,6-dicarboxamide, C15H23N7O4

“…Several hydrazidehydrazone derivatives have shown antimicrobial, antiviral, antimalarial, anticonvulsant, antiinflammatory, antituberculosis, antitumor, antiplatelet aggregation, antileishmanial, analgesic and antimalarial properties [4][5][6][7][8][9][10][11][12]. Furthermore, various substituted pyridines were recorded to exhibit antibacterial, anti-inflammatory and antitumor activity [13][14][15].…”

Crystal structure of 3-(pyrazin-2-ylamino)-2-benzofuran-1(3H)-one, C12H9N3O2

“…Benzofuranones are an important class of synthetic and naturally occurring products exhibiting diverse biological and pharmacological properties [3].P yrazines form an important class of analogues, which occupy aspecial role in natural and synthetic compounds [4]. Pyrazine derivatives are well knownfor their anticancer, antinociceptive, antimycobacterial,antiinflammatory activities [5][6][7][8].Inthis work we coupled benzofuranone withp yrazine ligands to produce the title compound3 -(pyrazin-2-ylamino)-2-benzofuran-1(3H)-one in good yield. In themolecule of the title compound, C 12 H 9 N 3 O 2 ,the essentiallyplanarphthalide groupisorientedatadihedralangle of 89.47°with respecttothe substituted aromatic ring.…”