New Cephalosporin Antibiotic— Cephaloridine

Turck, Marvin; Belcher, Donald W.; Ronald, Allan R.; Smith, Ronald H.; Wallace, James F.

doi:10.1001/archinte.1967.00290190098007

Cited by 28 publications

(8 citation statements)

References 15 publications

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“…On gram-negative bacteria cephaloridine seemed to be less effective than the other two compounds, with the exception of indole-negative Proteus spp. The results obtained with cephaloridine were in agreement with earlier studies (4,9,11).…”

Section: Resultssupporting

confidence: 92%

Comparative Study of the In Vitro Antibacterial Activity of Cefoxitin, Cefuroxime, and Cephaloridine

Norrby

Brorsson²,

Seeberg³

1976

Antimicrob Agents Chemother

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The in vitro antibacterial effects of cefoxitin, a semisynthetic cephamycin, cefuroxime, a new cephalosporin antibiotic, and cephaloridine were compared. With gram-positive bacteria, marked differences were found only in the effects against Streptococcus faecalis, where cephaloridine and cefuroxime were superior to cefoxitin. With gram-negative aerobic bacteria, cefoxitin, which is known to be more resistant to beta-lactamases from gram-negative bacteria than any cephalosporin, was found to be more effective than cefuroxime and cephaloridine against ampicillin-resistant strains of Escherichia coli and indole-positive strains of Proteus. Haemophilus influenzae was found to be more susceptible to cefuroxime than to cefoxitin and cephaloridine. When ampicillin-resistant strains of H. influenzae were tested, markedly higher minimal inhibitory concentration values were obtained with cephaloridine in comparison to those obtained with ampicillin-susceptible strains. These increases in the minimal inhibitory concentration values were not observed with cefoxitin and cefuroxime, probably due to the resistance of these two compounds to beta-lactamases. Strains ofBacteroides fragilis were found to be much more susceptible to cefoxitin than to cefuroxime, which in turn was superior to cephaloridine. The results obtained indicate that cefoxitin and cefuroxime both are superior in their antibacterial spectra to the cephalosporins that are now in clinical use.

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Section: Resultssupporting

confidence: 92%

Comparative Study of the In Vitro Antibacterial Activity of Cefoxitin, Cefuroxime, and Cephaloridine

Norrby

Brorsson²,

Seeberg³

1976

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

“…On the contrary, our results demonstrate, according to previous data of other Authors [16,23] that Cephaloridine was much less effective than Cephalothin against Staphylococci (especially penicillin-resistant penicillin ase-producing): this difference became apparent with a large inoculum and it has been related (see previously) to the greater susceptibility to in activation by penicillinase. Whether this relatively greater resistance of certain staphylococci will be of clinical significance is, at present, not known.…”

Section: Discussionsupporting

confidence: 85%

“…Cephaloridine shows better activity than sodium Cephalothin against E. coli, non-motile Klebsiella-Aerobacter, Proteus mirabilis strains. In addition [23], it was more active against Diplococcus pneumo niae and group A Streptococci.…”

Section: Discussionmentioning

confidence: 95%

“…A major problem with both Cephaloridine and sodium Cephalothin (especially in debilitated hospitalized patients) is the resistance of Pseudomonas and motile Klebsiella-Aerobacter strains: superinfections with these organisms are frequent and they have been documented with both drugs [3,6,23].…”

Section: Discussionmentioning

confidence: 99%

“…In general, it can be said that the levels of Cephaloridine greatly ex ceed the MIC of the infecting gram-positive strains, even six hours fol lowing administration of the drug, while for gram-negative pathogens the level of the antibiotic and the antibacterial activity of the serum were fre quently below the MIC of the infecting strain between four and six hours after intramuscular administration of the drug [23].…”

Section: Antibacterial Activity In Vitromentioning

confidence: 99%

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