Clinical Evaluation of Cephaloridine

Urinary Precipitate During Cephalothin-Cephaloridine Treatment

“…4 Renal dysfunction may occur during treatment with cephaloridine and, less frequently, with cephalothin.5 Acute toxic effects of cephaloridine include necrosis of the proximal convoluted tubules in mice, rats, guinea pigs, rabbits, monkeys, and man. [5][6][7][8][9] Repeated administration in rats of 50 to 150 mg/kg/day of cephaloridine produces proteinuria,10 while moderate to large doses may produce massive cylindruria in humans.7,11…”