New biomaterials through surface segregation phenomenon: New quaternary ammonium compounds as antibacterial agents

Nohr, Ronald S.; MacDonald, Jillian

doi:10.1163/156856294x00239

Cited by 85 publications

(44 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because systemic antibiotics often do not provide effective treatment for implant infections due to the phenomenon of drug resistance, it is important that the coating of the implant exhibit local antibacterial activity. In order to reduce the incidence of implant-associated infections, several biomaterial surface treatments have been proposed [18][19][20][21][22][23][24][25][26][27][28][29][30]. In particular, silver has raised the interest of many investigators because of its good antimicrobial action and low toxicity [30,[40][41][42][43].…”

Section: Discussionmentioning

confidence: 99%

“…Several biomaterial surface treatments have been proposed as a means of reducing the incidence of implant-associated infections. There has been investigation into the covalent attachment of polycationic groups [18,19]; ion implantation, such as F+ [20]; impregnating or loading chitosan nanoparticles with antimicrobial agents [21,22]; coating implant surfaces with polymers drug-loaded [23,24]; and coating implant surfaces with either quaternary ammonium compounds, human serum albumin, or silver ions [25][26][27][28][29][30]. However, there are several shortcomings of these proposed techniques including limited chemical stability, local inflammatory reactions due to material composition, and a lack of controlled release kinetics from the coatings.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antibacterial iodine-supported titanium implants

et al. 2011

View full text Add to dashboard Cite

Deep infection remains a serious complication in orthopedic implant surgery. In order to reduce the incidence of implant-associated infections, several biomaterial surface treatments have been proposed. This study focused on evaluating the antibacterial activity of iodine-supported titanium (Ti-I 2 ) and impact on post-implant infection, as well as determining the potential suitability of Ti-I 2 as a biomaterial.External fixation pins were used in this experiment as trial implants because it was easy to make the septic models.The antibacterial activity of the metal was measured using a modification of the Japanese Industrial Standards method. Activity was evaluated by exposing the implants to Staphylococcus aureus or Escherichia coli and comparing reaction of pathogens to the Ti-I 2 versus the stainless steel and titanium controls. The Ti-I 2 clearly inhibited bacterial colonization more than the control metals. In addition, cytocompatibility was assessed by counting the number of colonies that formed on the metals. The three metals showed the same amount of fibroblast colony formation.Japanese white rabbits were used as an in vivo model. Three pins were inserted into both femora of six rabbits for histological analysis. Pin sites were inspected and graded for infection and inflammation. Fewer signs of infection and inflammatory changes were observed in conjunction with the Ti-I 2 pins. Furthermore, osteoconductivity of the implant was evaluated with osteoid formation surface of the pin. Consecutive bone formation was observed around the Ti-I 2 and titanium pins, while little osteoid formation was found around the stainless steel pins. These findings suggest that Ti-I 2 has antimicrobial activity and cytocompatibility.Therefore, Ti-I 2 substantially reduces the incidence of implant infection and shows particular promise as a biomaterial.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antibacterial iodine-supported titanium implants

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Therefore, their effects were time-dependent, and generally short-lasting. The mechanical properties of the carrier material may deteriorate, and the materials released may be toxic if not properly controlled (8,9). To overcome the disadvantages of agent-releasing composites, some researchers have reported finishing several resin-based restorations with a composite resin, which is incorporated with a type of quaternary ammonium salt monomer, methacryloyloxydodecyl pyridinium bromide (MDPB), which exhibits antibacterial activities without leach-out of the incorporated monomer from the material (10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial effects of three experimental quaternary ammonium salt (QAS) monomers on bacteria associated with oral infections

et al. 2008

View full text Add to dashboard Cite

The aim of this study was to test the antibacterial effects of three experimental quaternary ammonium salt monomers in order to evaluate their potential applications as dental materials. In vitro susceptibility testing of the monomers was performed by the broth dilution method on bacteria associated with oral infections: Streptococcus mutans ATCC 25175, Actinomyces viscosus ATCC 15987, Staphylococcus aureus ATCC 29213 and Lactobacillus casei ATCC 393. The time-kill kinetics of the monomer with relatively higher antibacterial activity against S. mutans were also investigated. It was found that all the tested bacteria strains were susceptible to the three monomers, among which methacryloxylethyl cetyl ammonium chloride (DMAE-CB) exhibited the lowest minimal inhibitory concentrations, ranging from 1.2 to 4.8 µg/ml. The time-kill curve showed that DMAE-CB achieved 99.44% killing at 19.2 µg/ml (4 times the minimal bactericidal concentration) against S. mutans after 1 min and 100% killing within 10 min of contact. This result indicates that the quaternary ammonium salt monomer DMAE-CB may be a candidate antibacterial agent for incorporation into dental restorative materials. (J. Oral Sci. 50, [323][324][325][326][327] 2008) Keywords: quaternary ammonium salt; antibacterial effect; oral pathogenic bacteria; monomer; dental material.

show abstract

“…Basic research has been conducted regarding various metal surface treatments to reduce the rate of implant-associated infection [3][4][5][6][7][8]. Masse et al [16] used silver-coated pins for external fixation and reported an infection rate of 30%.…”

Section: Discussionmentioning

confidence: 99%

“…Such efforts included the development of antibacterial pins made of titanium-copper alloys [3] and metal surface treatment involving silver, antibacterial agents, hyaluronic acid, and albumin [4][5][6][7][8]. We have been creating an oxide film on titanium surfaces by anodization and have been developing techniques to impregnate this multiple porous film with the antiseptic properties of iodine (Fig.…”

Section: Introductionmentioning

confidence: 99%