Prevention of pin tract infection with iodine-supported titanium pins

Shirai, Toshiharu; Watanabe, Koji; Matsubara, Hidenori; Nomura, Issei; Fujiwara, Hiroyoshi; Ikoma, Kazuya; Terauchi, Ryu; Kubo, Toshikazu; Tsuchiya, Hiroyuki

doi:10.1007/s00776-014-0561-z

Cited by 35 publications

(19 citation statements)

References 22 publications

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“…An innovative technology using iodine to produce porous anodic oxide implant surfaces with the antiseptic properties of iodine was studied in a prospective uncontrolled cohort study for both prophylaxis in high risk patients, and for treatment in confirmed MSK infection cases . Confirmatory reports on subsets of these patients with hip replacement implants or fixator pins reported no hip implant infections and decreased pin tract infections respectively …”

Section: Resultsmentioning

confidence: 99%

2018 international consensus meeting on musculoskeletal infection: Summary from the biofilm workgroup and consensus on biofilm related musculoskeletal infections

Saeed

McLaren²,

Schwarz³

et al. 2019

Journal Orthopaedic Research

129

123

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Biofilm-associated implant-related bone and joint infections are clinically important due to the extensive morbidity, cost of care and socioeconomic burden that they cause. Research in the field of biofilms has expanded in the past two decades, however, there is still an immense knowledge gap related to many clinical challenges of these biofilm-associated infections. This subject was assigned to the Biofilm Workgroup during the second International Consensus Meeting on Musculoskeletal Infection held in Philadelphia USA (ICM 2018) (https://icmphilly.com). The main objective of the Biofilm Workgroup was to prepare a consensus document based on a review of the literature, prepared responses, discussion, and vote on thirteen biofilm related questions. The Workgroup commenced discussing and refining responses prepared before the meeting on day one using Delphi methodology, followed by a tally of responses using an anonymized voting system on the second day of ICM 2018. The Working group derived consensus on information about biofilms deemed relevant to clinical practice, pertaining to: (1) surface modifications to prevent/inhibit biofilm formation; (2) therapies to prevent and treat biofilm infections; (3) polymicrobial biofilms; (4) diagnostics to detect active and dormant biofilm in patients; (5) methods to establish minimal biofilm eradication concentration for biofilm bacteria; and (6) novel anti-infectives that are effective against biofilm bacteria. It was also noted that biomedical research funding agencies and the pharmaceutical industry should recognize these areas as priorities. ß

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Section: Resultsmentioning

confidence: 99%

2018 international consensus meeting on musculoskeletal infection: Summary from the biofilm workgroup and consensus on biofilm related musculoskeletal infections

Saeed

McLaren²,

Schwarz³

et al. 2019

Journal Orthopaedic Research

129

123

View full text Add to dashboard Cite

show abstract

“…The reported incidence of external fixation infection was 3–80% according to different diagnostic criteria . Risk factors for acquiring pin‐tract infections include patient factors (advanced age or smoking) and external fixator parameters (prolonged duration or types of pin) . Various methods, such as regular cleansing with different solutions and specific dressings, have been applied to prevent infections .…”

Section: Discussionmentioning

confidence: 99%

Combined use of Kirschner wires and hinged external fixator for capitellar and trochlear fractures: a minimum 24‐month follow‐up

Zhao

Guo

et al. 2018

ANZ Journal of Surgery

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Background: Open reduction and internal fixation is the adequate treatment for capitellar and trochlear fractures. Given the low incidence of this type of fractures, it is difficult to constitute a universally accepted method for fixation. Thus, we hypothesised that combined use of Kirschner wires (K-wires), absorbable rods and sutures for fixation and post-operative hinged external fixator for early rehabilitation exercise can restore elbow joint function well. Methods: This retrospective study included 20 patients with a mean age of 48.3 (range 16-76) years. According to the Dubberley classification, fractures were classified on plain radiographs, computed tomography images and intra-operative findings. All patients were evaluated by the range of motion of the elbow and the Broberg-Morrey score. Results: All fractures had healed without non-union, and the average time was 13.6 (range 8-17) weeks. The mean follow-up was 42.5 (range 24-80) months. The mean flexion was 117.1 (range 90 -135 ), and the mean extension was 17.5 (range 0 -45 ). The mean pronation was 74.4 (range 45 -85 ), and the mean supination was 84.3 (range 60 -90 ). The average Broberg-Morrey score was 86.2 (range 68-98) points with 10 excellent, 7 good and 3 fair results. Conclusion: K-wires, absorbable rods and sutures combined with hinged external fixator are feasible for fixation of capitellar and trochlear fractures. However, due to the absence of a control group (such as Herbert screw fixation), comparative studies are still needed to demonstrate the safety and reliability of K-wires for fixation.

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“…The biological half-life of an antibiotics coating or silver coating is said to be only several hours or days [ 15 , 16 ]. On the other hand, recent data showed that the amount of iodine on the titanium pin in patients with external fixation was maintained, with approximately 40% remaining after 1 year [ 17 ]. Fifth, iodine-supported implants have excellent osteoconduction and good biocompatibility [ 11 ]; bone conduction is reportedly not possible on certain materials such as silver [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Iodine-Supported Hip Implants: Short Term Clinical Results

Kabata

Maeda

Kajino

et al. 2015

BioMed Research International

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We developed a new povidone iodine coating technology for titanium hip implants and performed a clinical trial to assess its usefulness in suppressing postoperative infection. Results indicate that iodine-supported titanium has favorable antibacterial activity, biocompatibility, and no cytotoxicity. Thirty joints in 28 patients were treated using iodine-supported implants. Fourteen joints were revision total hip arthroplasty (THA) after periprosthetic infection, 13 were primary THA for immunosuppressive conditions or pyogenic arthritis, and 3 were conversions from hemiarthroplasty to THA for immunosuppressive conditions. Two examinations were conducted sequentially until final follow-up: white blood cell (WBC) and C-reactive protein (CRP) were measured pre- and postoperatively and thyroid hormone levels in the blood were examined. The mean follow-up period was 33 months (14–78). There were no signs of infection in any patient at the last follow-up. WBC and CRP levels returned to normal within several weeks. No abnormalities of thyroid gland function were detected. Loosening of the implants did not occur in any patient. Excellent bone ingrowth and ongrowth were found around prostheses. No cytotoxicity or adverse effects were detected. These results suggest that iodine-supported THA implants can be highly effective in preventing and treating postoperative infections.

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Prevention of pin tract infection with iodine-supported titanium pins

Abstract: Background Pin tract infection is one of the most common complications of external fixation.

Cited by 35 publications

References 22 publications

2018 international consensus meeting on musculoskeletal infection: Summary from the biofilm workgroup and consensus on biofilm related musculoskeletal infections

2018 international consensus meeting on musculoskeletal infection: Summary from the biofilm workgroup and consensus on biofilm related musculoskeletal infections

Combined use of Kirschner wires and hinged external fixator for capitellar and trochlear fractures: a minimum 24‐month follow‐up

Iodine-Supported Hip Implants: Short Term Clinical Results

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