New bimetallic dicyanidoargentate(I)-based coordination compounds: Synthesis, characterization, biological activities and DNA-BSA binding affinities

2020

Turk J Chem

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Coordination compounds containing dicyanoargentate(I) have remarkable biological potential due to their therapeutic antibacterial, antifungal, antibiofilm, and anticancer properties. In this study, a new dicyanoargentate(I)based complex was synthesized and characterized by various procedures (elemental, thermal, FT-IR for complex) involving crystal analysis of the complex. In addition, the biological activity of this new compound on the acetylcholinesterase (AChE) enzyme, an important enzyme for the nervous system, was investigated. When the infrared (IR) spectrum of the complex is examined, the OH vibration peak resulting from H 2 O molecules in the structure at 3948-3337 cm −1 and at 2138 cm −1 , along with a CN peak coordinated to Ag, can be seen, indicating that the mass remaining in the thermal degradation of the complex at 1000 • C is the weight corresponding to the metal mixture consisting of K + Ag (calc.: 68.06). The crystal method revealed that the complex has a sandwich-like, polymeric chemical structure with layers formed by K + cations and [Ag(CN) 2 H 2 O] − anions. Therefore, the AChE enzyme has potential therapeutic uses in improving ACh levels in brain cells, in reducing various side effects, and in improving cognitive impairment, especially in advanced Alzheimer's disease patients. In this study, the activity of this newly synthesized complex on AChE was also investigated. As a result of this research, [Ag(CN) 2 (H 2 O)K] had 0.0282 ± 0.010 µ M Ki values against AChE. The compound was therefore a good inhibitor for the AChE enzyme. This type of compound can be used for the development of novel anticholinesterase drugs.

Section: Crystal Structure Of Complexsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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New sandwich-type polymeric potassium-dicyanoargentate(I) complex: synthesis, characterization and enzymatic activity

2020

Turk J Chem

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“…In this part, 10 K, for 1 and 2 could be very tiny antiferromagnetic interplay in the chemical structure, as observed in the insertion of Figures S10 and S11. The magnetic of 1 and 2 recorded a resemblance to tetracyanidometallate containing similar neutral ligands 33,34,48,49,[65][66][67][68] . They even exhibited antiferromagnetic properties at low temperatures as in complexes 1 and 2 33,48,49,[65][66][67][68]71,72 .…”

Section: Resultsmentioning

confidence: 95%

“…When the Lande g values of Cu 2+ complexes containing tetracyanidometallate having neutral ligands are compared with those of complex 2, it is noticed that g amounts are g // > g ⊥ > g e33,34,48,49,[65][66][67][68] .…”

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confidence: 99%

Metalo components exhibiting significant anticancer and antibacterial properties: a novel sandwich-type like polymeric structure

Karadağ

Aydın

et al. 2020

Sci Rep

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Four new dicyanoargentate(I)-based complexes 1-4 were synthesized from certain metal ions with a tetradentate ligand [N, N-bis (2-hydroxyethyl)-ethylenediamine; N-bishydeten] and determined by diverse procedures (elemental, thermal, FT-IR, ESI-MS for 1-3 and, magnetic susceptibility and EPR for 1, and 2) including crystal analysis of 4. The crystal method revealed that complex 4 has a sandwich-type like polymeric chemical structure with layers formed by [Cd(N-bishydeten) 2 ] 2+ cations and [Ag(CN) 2 ] − anions. The complexes were further characterized by fluorescence and UV spectroscopy to determine their physicochemical features. The complexes displayed a DNA binding activity within the same range as found for cisplatin, in addition to their strong stability in the presence of the physiological buffer system. The complexes were also investigated for pharmacological properties like interaction with DNA/Bovine serum albumin, anticancer and antibacterial activities. Physicochemical studies of DNA with the complexes suggested that the interaction mode between them are possibly both intercalative and groove binding types. These spectroscopic measurements also show that there may be a binding tendency between BSA and the complexes via hydrogen or Van der Waals bonds. The viability tests demonstrated that all the complexes exhibited antibacterial (1-4) and anticancer effects (2-4) toward ten diverse bacterial strains and three tumor cells (HT-29 colon adenocarcinoma, HeLa cervical cancer, and C6 glioma), respectively. Despite the current advances in cancer therapy, the death rate from cancer and therapeutic agents are still increasing 1. A significant number of studies have focused on the synthesis and design of a new antiproliferative agent to reduce the risk of drug resistance and cell toxicity 2-4. Some of these studies are related to metallo compounds which constitute a significant part of agents with potent pharmacological activities, and their medicinal availability has been still explored 5,6. For example, some macrocyclic polyamines containing Ni, Cu, and Ru could recognize TAR RNA molecules and cleave them, and affect the interaction of Tat-RNA 7. Mn(II) complex of 2H-5-hydroxy-1,2,5-oxadiazo[3,4-f]1,10-phenanthroline has significant antitumor activity against HL-60, KB, Hela and BGC-823 cells.

Dicyanoargentate(I)‐based complexes induced in vivo tumor inhibition by activating apoptosis‐related pathways

Aydın

Kısa

et al. 2022

Applied Organom Chemis

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Colorectal adenocarcinoma, which often occurs as a result of a typical chromosomal instability and mismatch repair deficiencies resulting in resistance to apoptosis, is a significant burden on society. Previously, we demonstrated strong apoptosis triggers Ag(I) complexes in vitro, including [Ni (hydeten)2Ag(CN)2] [Ag (CN2].H2O (C1), [Ni (bishydeten)2] [Ag (CN)2]2.H2O (C2), and [Ni(N‐bishydeten)Ag3(CN)5] (C3), which specifically induce the apoptotic mechanism of cancer cells and selectively is non‐cytotoxic within normal cells. Herein, we introduce in vivo the ability of Ag(I) complexes to activate apoptosis and interact with cell cycle and cell fate‐related proteins. To assess antitumor efficacy, we evaluated tumor volume, survival rate, and protein status related to cell cycle, apoptosis, and oxidative stress (by immunohistochemistry, genetic expression, and ELISA assays). In addition, in this study, using molecular docking study, the interactions of metal complexes on many proteins were examined, and the findings related to their theoretical anticancer activities were obtained and compared. The in vivo evaluation of Ag(I) complexes (10 mg/kg) against HT29 xenograft tumor model in the CD1 nude and BALB/c mice revealed a remarkable decrease in the tumor volume and increase survival rate. The weight‐loss situation and histopathological indicators of Ag(I) complexes‐treated mice approved that the Ag(I) complexes have a considerable healing effect on solid tumors with negligible side‐effect on the tissue. This promising information strongly expresses that Ag(I) complexes may fulfill the task of an antitumor agent and be a potential candidate for a chemotherapeutic approach against colorectal adenocarcinoma.